The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Shamalov N.A.

Research Institute of cerebrovascular pathology and stroke of the Pirogov Russian national research medical University, Moscow, Russia

Stakhovskaya L.V.

Pirogov Russian National Research Medical University, Moscow, Russia

Burenchev D.V.

Gorodskaia klinicheskaia bol'nitsa #20, Moskva

Kichuk I.V.

Kafedra fundamental'noĭ, klinicheskoĭ nevrologii i neĭrokhirurgii Rossiĭskogo gosudarstvennogo meditsinskogo universiteta, NII tserebrovaskuliarnoĭ patologii i insul'ta Nauchnogo tsentra psikhicheskogo zdorov'ia RAMN, Moskva

Tvorogova T.V.

Gorodskaia klinicheskaia bol'nitsa #20, Moskva

Botsina A.Iu.

Rossiĭskiĭ gosudarstvennyĭ meditsinskiĭ universitet, Moskva

Smychkov A.S.

Rossiĭskiĭ gosudarstvennyĭ meditsinskiĭ universitet, Moskva

Kerbikov O.B.

Rossiĭskiĭ gosudarstvennyĭ meditsinskiĭ universitet, Moskva

Messler G.

Ébeve Neĭro Farma GmbKh, Avstriia

Novak F.

ÉBEVE Farma, Avstriia

Skvortsova V.I.

Rossiĭskiĭ gosudarstvennyĭ meditsinskiĭ universitet;
NII tserebrovaskuliarnoĭ patologii i insul'ta, Moskva

The effect of cerebrolysin in dosage 50 ml on the volume of lesion in ischemic stroke

Authors:

Shamalov N.A., Stakhovskaya L.V., Burenchev D.V., Kichuk I.V., Tvorogova T.V., Botsina A.Iu., Smychkov A.S., Kerbikov O.B., Messler G., Novak F., Skvortsova V.I.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2010;110(12‑2): 34‑37

Views: 2716

Downloaded: 41

Download PDF (RU)
Contact the author
Table of contents

THE EFFECT OF CEREBROLYSIN IN DOSAGE 50 ML ON THE VOLUME OF LESION IN ISCHEMIC STROKE
THE EFFECT OF CEREBROLYSIN IN DOSAGE 50 ML ON THE VOLUME OF LESION IN ISCHEMIC STROKE

To cite this article:

Shamalov NA, Stakhovskaya LV, Burenchev DV, et al. . The effect of cerebrolysin in dosage 50 ml on the volume of lesion in ischemic stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2010;110(12‑2):34‑37. (In Russ.)

Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
 
 
МСФ на ЯМ
Close metadata
Recommended articles:
Cognitive impairment in patients with arte­rial hype­rtension. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(4-2):41-48
Brain-derived neurotrophic factor in the acute and early reco­very period of ischemic stroke: the role of nocturnal hypo­xemia. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(5-2):72-78
Indi­cators of cognitive impairment of varying seve­rity in the acute period of ischemic stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(8-2):14-20
Repeated ischemic stro­kes due to infe­ctious arte­ritis of both inte­rnal caro­tid and basi­lar arte­ries as a complication of sphe­noiditis and otitis. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(8-2):31-37
Cases of successful thro­mbus extraction in ischemic stroke asso­ciated with the new coro­navirus infe­ction COVID-19. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(8-2):38-46
On the issue of opti­mizing protein and energy supply for patients with acute cere­brovascular acci­dent. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(8-2):51-55
Place of oligopeptide H-Met-Glu-His-Phe-Pro-Gly-Pro-OH in the therapy and reha­bilitation of patients with ischemic stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(8-2):56-63
Cognitive impairment in post-traumatic stress diso­rder. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(5):69-74
Methods of cost-effectiveness evaluation of endo­vascular patent fora­men ovale closure for seco­ndary prevention of cryptogenic stroke. Russian Journal of Preventive Medi­cine. 2024;(6):105-110
Possibilities of physiotherapy in glaucomatous optic neuropathy after glaucoma surgery. Russian Annals of Ophthalmology. 2024;(3):88-94

The purpose of this randomized, double-blind, placebo-controlled study was to assess safety and efficacy of cerebrolysin used in dosage 50 ml in acute ischemic stroke. Forty-seven patients with ischemic stroke, aged 45-85 years, who were admitted to a clinical unit within the first 12 h after stroke onset were included in the study. A quantitative time-related MRI analysis of the dynamics of neurological deficit revealed the more rapid decrease of stroke volume to the 28th day in the group treated with cerebrolysin (45,4% versus 43,6% in the placebo-group (p<0,05) ). No side-effects of treatment with cerebrolysin was found. The results of this prospective, randomized, placebo-controlled study suggest the positive effect of cerebrolysin on the dynamics of volume lesion in patients with ischemic stroke.

Keywords:

ischemic stroke
neuroprotection
cerebrolysin

Authors:

Shamalov N.A.

Research Institute of cerebrovascular pathology and stroke of the Pirogov Russian national research medical University, Moscow, Russia

Stakhovskaya L.V.

Pirogov Russian National Research Medical University, Moscow, Russia

Burenchev D.V.

Gorodskaia klinicheskaia bol'nitsa #20, Moskva

Kichuk I.V.

Kafedra fundamental'noĭ, klinicheskoĭ nevrologii i neĭrokhirurgii Rossiĭskogo gosudarstvennogo meditsinskogo universiteta, NII tserebrovaskuliarnoĭ patologii i insul'ta Nauchnogo tsentra psikhicheskogo zdorov'ia RAMN, Moskva

Tvorogova T.V.

Gorodskaia klinicheskaia bol'nitsa #20, Moskva

Botsina A.Iu.

Rossiĭskiĭ gosudarstvennyĭ meditsinskiĭ universitet, Moskva

Smychkov A.S.

Rossiĭskiĭ gosudarstvennyĭ meditsinskiĭ universitet, Moskva

Kerbikov O.B.

Rossiĭskiĭ gosudarstvennyĭ meditsinskiĭ universitet, Moskva

Messler G.

Ébeve Neĭro Farma GmbKh, Avstriia

Novak F.

ÉBEVE Farma, Avstriia

Skvortsova V.I.

Rossiĭskiĭ gosudarstvennyĭ meditsinskiĭ universitet;
NII tserebrovaskuliarnoĭ patologii i insul'ta, Moskva

List of references:

  1. Gusev E.I., Skvortsova V.I., Stakhovskaya L.V. Zhurn nevrol i psikhiatr 2003;8:4-9 (Insul't prilozhenie k zhurnalu).
  2. Tatebayashi T. et al. The dentate girus neurogenesis: A therapeutic effect for Alzheimer disease. Acta Neuropatol 2003;105:225-232.
  3. Ladurner G., Kalvach P., Moessler H. Cerebrolysin Study Group. Neuroprotective treatment with cerebrolysin in patients with acute stroke: a randomised controlled trial. J Neurol Transm 2005;112:3:415-428.
  4. Koppi S., Barolin G.S. Primenenie tserebrolizina v terapii ishemicheskogo insul'ta. Zhurn nevrol i psikhiatr 1998;10:30-34.
  5. Skvortsova V.I., Stakhovskaya L.V., Gubskii L.V. i dr. Randomizirovannoe dvoinoe slepoe platsebo-kontroliruemoe issledovanie bezopasnosti i effektivnosti tserebrolizina dlya lecheniya ostrogo ishemicheskogo insul'ta. Zhurn nevrol i psikhiatr 2004;11 (Insul't prilozhenie k zhurnalu).
  6. Schwab M. et al. Brain-derived peptides reduce the size of cerebral infarction and loss of MAP2 immunoreactivity after focal ischemia in rats. Ageing and Dementia. J Neurol Transmis 1998;Suppl 53:299-313.
  7. Hutter-Paier B. et al. Cerebrolysin protects neurons from ischemia-induced loss of microtubule-associated protein. J Neurol Transm 1996;47:276.
  8. Schwab M. et al. Effects of Cerebrolysin on cytoskeletal proteins after focal ischemia in rats. Ageing and Dementia. J Neurol Transmis 1996;Suppl 47:279.

Close metadata

Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.