This article describes the modern approaches to the application of physical factors for the treatment of various forms of psoriasis taking into consideration the severity of clinical manifestations and the phase of the disease, the extent of disturbances of the functional state of different organs. The principles of prescription of physiotherapeutictreatmnt are formulated taking account of the stages and forms of the disease. Special attention is paid to the high therapeutic effectiveness of ultraviolet irradiation of the skin including narrow-band UVВ (311 nm) as well as to photodynamic therapy (PUVA), intravenous laser irradiation of blood, and ozone therapy. Also considered is the spa and health resort-based treatment and peloid therapy at various stages of the pathological process. The application of the combined techniques is described with special reference to radon and hydrogen sulfide baths and microwave therapy in the patients presenting with psoriatic arthritis. Much attention is given to the effectiveness of the prescription of the spa and health resort-based treatment at the stationary and regressive stages of psoriasis. The pathogenetic mechanisms underlying the therapeutic action of the physical factors used for the treatment of patients suffering from psoriasis are discussed.