The pathogenetic rationale for the application of reflexotherapy in the rehabilitation of the patients presenting with cognitive disorders

Razumov A.N.; Mel'nikova E.A.

doi:https://doi.org/

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Abstract:

Cognitive disorders (CD) of variable severity are currently one of the leading causes of disability in the patients presenting with vascular and degenerative diseases of the brain; it is especially true of Alzheimer's disease. The discovery of the universal pathogenetic mechanism underlying the development of CD made it possible to explain the known cases of the successful application of acupuncture in the patients with disorders of seemingly different origin. The results of these studies suggest that acupuncture can affect the key pathogenetic "functional circles" involved in the development of CD. The present article is focused on the description of the humoral, neurotransmitter and electrophysiological mechanisms through which the positive effects of acupuncture on the cognitive function of the patients with various diseases are mediated.

Keywords:

cognitive disorders

dementia

cerebrovascular disease

Alzheimer's disease

reflexology

puncture physiotherapy

acupuncture

Authors:

Razumov A.N.

GBUZ "Moskovskiĭ nauchno-prakticheskiĭ tsentr meditsinskoĭ reabilitatsii, vosstanovitel'noĭ i sportivnoĭ meditsiny" Departamenta zdravookhraneniia Moskvy

SPIN RSCI: 8793-5173
ORCID: 0000-0001-8549-0106

Mel'nikova E.A.

Kafedra fundamental'noĭ i klinicheskoĭ nevrologii i neĭrokhirurgii Rossiĭskogo gosudarstvennogo meditsinskogo universiteta, Moskva

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References:

Mel'nikova E.A., Krylov V.V. Cognitive disorders in the patients following the surgical treatment of intracranial arterial aneurysms. Voprosy neirokhirurgii im. N.N. Burdenko. 2008; 2: 50-3. [In Russ.].
Mel'nikova E.A., Krylov V.V. The neuropsychological outcomes after the early surgical treatment of aneurysms of the cerebral vessels. Neirokhirurgiya. 2008; 4: 21-9. [In Russ.].
Dai W., Lopez O.L., Carmichael O.T., , Becker J.T., Kuller L.H., Gach H.M. Mild cognitive impairment and Alzheimer disease: patterns of altered cerebral blood flow at MR imaging. Radiology. 2009; 250 (3): 856-66.
Hogan D.B., Bailey P., Black S., Carswell A., Chertkow H., Clarke B., Cohen C., Fisk J.D., Forbes D., Man-Son-Hing M., Lanctôt K, Morgan D., Thorpe L. Diagnosis and treatment of dementia: 5. Nonpharmacologic and pharmacologic therapy for mild to moderate dementia. Can. Med. Assoc. J. 2008; 179 (10): 1019-26.
Khedr E.M., Hamed S.A., El-Shereef H.K., Shawky O.A., Mohamed K.A., Awad E.M., Ahmed M.A., Shehata G.A., Eltahtawy M.A. Cognitive impairment after cerebrovascular stroke: Relationship to vascular risk factors. Neuropsychiatr. Dis. Treat. 2009; 5: 103-16.
Schaller B.J. Strategies for molecular imaging dementia and neurodegenerative diseases. Neuropsychiatr. Dis. Treat. 2008; 4 (3): 585-612.
Stephan B.C., Matthews F.E., Khaw K.T., Dufouil C., Brayne C. Beyond mild cognitive impairment: vascular cognitive impairment, no dementia (VCIND). Alzheimer's Res. Ther. 2009; 1 (1): 4.
Feldman H.H., Jacova C., Robillard A., Garcia A., Chow T., Borrie M., Schipper H.M., Blair M., Kertesz A., Chertkow H. Diagnosis and treatment of dementia: 2. Diagnosis. Can. Med. Assoc. J. 2008; 178 (7): 825-36.
Hogan D.B., Bailey P., Black S., Carswell A., Chertkow H., Clarke B., Cohen C., Fisk J.D., Forbes D., Man-Son-Hing M., Lanctôt K., Morgan D., Thorpe L. Diagnosis and treatment of dementia: 4. Approach to management of mild to moderate dementia. Can. Med. Assoc. J. 2008; 179 (8): 787-93.
Droste D.W., Ritter M.A., Dittrich R., Heidenreich S., Wichter T., Freund M., Ringelstein E.B. Arterial hypertension and ischaemic stroke. Acta Neurol. Scand. 2003; 107 (4): 241-51.
Auerbach I.D., Sung S.H., Wang Z., Vinters H.V. Smooth muscle cells and the pathogenesis of cerebral microvascular disease ("Angiomyopathies"). Exp. Mol. Pathol. 2003; 74 (2): 148-59.
Fernando M.S., Simpson J.E., Matthews F., Brayne C., Lewis C.E., Barber R., Kalaria R.N., Forster G., Esteves .F, Wharton S.B., Shaw P.J., O'Brien J.T., Ince P.G.; MRC Cognitive Function and Ageing Neuropathology Study Group. White matter lesions in an unselected cohort of the elderly: molecular pathology suggests origin from chronic hypoperfusion injury. Stroke. 2006; 37 (6): 1391-8.
Iadecola C., Davisson R.L. Hypertension and cerebrovascular dysfunction. Cell Metab. 2008; 7: 476-84.
Iadecola C., Park L., Capone C. Threats to the mind: aging, amyloid, and hypertension. Stroke. 2009; 40 (3, Suppl.): 40-4.
Johnson K.A., Albert M.S. Perfusion abnormalities in prodromal AD. Neurobiol. Aging. 2000; 21 (2): 289-92.
Mehta P.K., Griendling K.K. Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system. Am. J. Physiol. Cell Physiol. 2007; 292 (1): C82-97.
O'Sullivan M., Lythgoe D.J., Pereira A.C., Summers P.E., Jarosz J.M., Williams S.C., Markus H.S. Patterns of cerebral blood flow reduction in patients with ischemic leukoaraiosis. Neurology. 2002; 59 (3): 321-6.
Klann E., Dever T.E. Biochemical mechanisms for translational regulation in synaptic plasticity. Nat. Rev. Neurosci. 2004; 5: 931-42.
Lambeth J.D. Nox enzymes, ROS, and chronic disease: an example of antagonistic pleiotropy. Free Radic. Biol. Med. 2007; 43 (3): 332-47.
Guo X.X., Jin H.S., Huo L., Zheng J., Zhou X.M. Meta-analysis on acupuncture for treatment of dementia. Zhongguo Zhen Jiu. 2008; 28 (2): 140-4.
Peng W.N., Zhao H., Liu Z.S., Wang S. Acupuncture for vascular dementia. Cochrane Database Syst. Rev. 2007; (2): CD004987.
Yang M.H., Lin L.C. Acupressure in the care of the elderly. Hu Li Za Zhi. 2007; 54 (4): 10-5.
Liu C.Z., Yu J.C., Zhang X.Z., Fu W.W., Wang T., Han J.X. Acupuncture prevents cognitive deficits and oxidative stress in cerebral multi-infarction rats. Neurosci. Lett. 2006; 393 (1): 45-50.
Lu Y.W., Lu M.Z. Effects of ear point needle embedding therapy on memory disorder and expression of beta-amyloid protein in the rat of vascular dementia. Zhongguo Zhen Jiu. 2006; 26 (11): 804-8.
Chuang C.M., Hsieh C.L., Li T.C., Lin J.G. Acupuncture stimulation at Baihui acupoint reduced cerebral infarct and increased dopamine levels in chronic cerebral hypoperfusion and ischemia-reperfusion injured sprague-dawley rats. Am. J. Chin. Med. 2007; 35 (5): 779-91.
Shao Y., Lai X.S., Gong Y.Z., Yan B., He L.L., Luo R., Tang C.Z. Effects of electroacupuncture on plasma and cerebral somatostatin and beta-EP contents and learning-memory ability in vascular dementia rats. Zhen Ci Yan Jiu. 2008; 33 (2): 98-102.
Ren L., Zhang W.A., Fang N.Y., Wang J.X. The influence of electro-acupuncture on neural plasticity in acute cerebral infarction. Neurol. Res. 2008; 30 (9): 985-9.
Luo Y., Xu N.G., Yi W., Du Y.X. Effect of electroacupuncture on astrocytes in the marginal zone of cerebral ischemia locus in rats. Zhen Ci Yan Jiu. 2009; 34 (2): 101-5.
Qian Y.F., Fan X.N., Li Y.J., Zhang Y.N., Wei Y.Y., Zhang X., Wu H.Q., Wang S., Shi X.M. Effects of acupuncture at different acupoints on cerebral blood flow in cerebral ischemia model rats. Zhongguo Zhen Jiu. 2009; 29 (3): 213-6.
Fang J., Jin Z., Wang Y., Li K., Kong J., Nixon E.E., Zeng Y., Ren Y., Tong H., Wang Y., Wang P., Hui K.K. The salient characteristics of the central effects of acupuncture needling: limbic-paralimbic-neocortical network modulation. Hum. Brain Mapp. 2009; 30 (4): 1196-206.
Cai S.X., Yu W.J., Zhang L., Wang X.Z., Zhao Y., Chen S.J. Effect of electroacupuncture on plasma endogenous endothelial progenitor cell counts in cerebral ischemia-reperfusion rats. Zhen Ci Yan Jiu. 2009; 34 (2): 114-9.
Liu Z.B., Niu W.M., Yang X.H., Niu X.M. Clinical investigation on electroacupuncture treatment of vascular dementia with "Xiusanzhen". Zhen Ci Yan Jiu. 2008; 33 (2): 131-4.
Ulett G.A., Han S., Han J.S. Electroacupuncture: mechanisms and clinical application. Biol. Psychiatry. 1998; 44 (2): 129-38.
Sher L. The role of the endogenous opioid system in the effects of acupuncture on mood, behavior, learning, and memory. Med. Hypothes. 1998; 50 (6): 475-8.
Niu W.M., Liu Z.B., Yang X.H., Niu X.M., Wang Y. Effect of "Xiusanzhen" on learning-memory ability and hippocampal somatostatin and arginin vasopressin contents in vascular dementia rats. Zhen Ci Yan Jiu. 2009; 34 (2): 106-9.
Farkas E., Luiten P.G. Cerebral microvascular pathology in aging and Alzheimer's disease. Prog. Neurobiol. 2001; 64: 575-611.
Zhu S.X., Sun G.J. Effects of electroacupuncture on learning and memory ability and glial cells of the hippocampus in the rat of Alzheimer disease. Zhongguo Zhen Jiu. 2009; 29 (2): 133-6.
Zlokovic B.V. The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron. 2008; 57: 178-201.
Qian X.P., Xu F., Song J.L., Zhao J.H. Influence of different frequencies of acupuncture on therapeutic effect in patients with cerebral infarction at convalescence. Zhongguo Zhen Jiu. 2009; 29 (1): 7-9.
Yu J., Yu T., Han J. Aging-related changes in the transcriptional profile of cerebrum in senescence-accelerated mouse (SAMP10) is remarkably retarded by acupuncture. Acupunct. Electrother. Res. 2005; 30 (1-2): 27-42.
Wang L., Tang C., Lai X. Effects of electroacupuncture on learning, memory and formation system of free radicals in brain tissues of vascular dementia model rats. J. Tradit. Chin. Med. 2004; 24 (2): 140-3.
Wang T., Liu C.Z., Yu J.C. Acupuncture protected cerebral multi-infarction rats from memory impairment by regulating the expression of apoptosis related genes Bcl-2 and Bax in hippocampus. Physiol. Behav. 2009; 96 (1): 155-61.
Zhang H.Z., Zhang L.X., She Y.F., Li W.L., Zhang X.J., Zhang R.J. Effects of electroacupuncture on apoptosis of hippocampus tissue in mice with vascular dementia. Zhen Ci Yan Jiu. 2008; 33 (6): 377-81.
Lin S.J., Wang W. Effect of electroacupuncture on NMDAR-2 B mRNA expression in hippocampal tissue in vascular dementia rats. Zhen Ci Yan Jiu. 2008; 33 (5): 301-5.
Yan B., Li K., Xu J., Wang W., Li K., Liu H., Shan B., Tang X. Acupoint-specific fMRI patterns in human brain. Neurosci. Lett. 2005; 383 (3): 236-40.
Huang Y., Chen J., Htut W.M., Lai X., Wik G. Acupuncture increases cerebral glucose metabolism in human vascular dementia. Int. J. Neurosci. 2007; 117 (7): 1029-37.
Yang M.H., Wu S.C., Lin J.G., Lin L.C. The efficacy of acupressure for decreasing agitated behaviour in dementia: a pilot study. J. Clin. Nurs. 2007; 16 (2): 308-15.
Razumov A.N., Namsaraeva G.T. The analysis of the modern views of the prospects for the application of the traditional therapeutic and health-improving methods in rehabilitative medicine. V kn.: Sbornik materialov 7-go mezhdunarodnogo kongressa "Vosstanovitel'naya meditsina I reabilitatsiya 2010" (In: Collected materials of the 7th International congress "Remedial medicine and rehabilitation 2010"). М.; 2010: 98-100. [In Russ.].
Huang Q. Fifty cases of vertebrobasilar ischemic vertigo treated by acupuncture. J. Tradit. Chin. Med. 2009; 29 (2): 87-9.
Yu J., Zhang X., Liu C., Meng Y., Han J. Effect of acupuncture treatment on vascular dementia. Neurol. Res. 2006; 28 (1): 97-103.
Sun Y.Z., Zhu P.Y., Zhang M., Zhang Y. Clinical observation on Yuanluo Tongjing needling method for treatment of mild cognitive impairment. Zhongguo Zhen Jiu. 2007; 27 (11): 810-2.
Liu Z.B., Niu W.M. Observation on therapeutic effect of puncturing with needles in alignment at the hairline region on vascular dementia. Zhongguo Zhen Jiu. 2007; 27 (6): 412-4.
Chu J.M., Bao Y.H., Zou C. Effect of long-time retention of scalp needle on the abilities of cognition, daily living activity and P300 in vascular dementia patients. Zhen Ci Yan Jiu. 2008; 33 (5): 334-8.
Bai H.M., Zhang Y.L., He J.W., Zhang L.C., Yang Y. Observation on therapeutic effect of comprehensive therapy for acute large area cerebral infarction. Zhongguo Zhen Jiu. 2008; 28 (2): 98-100.
Zhang H., Zhao L., He C.Q., Hu K.M., Liu J. Clinically multi-central randomized controlled study on scalp electroacupuncture for treatment of vascular dementia. Zhongguo Zhen Jiu. 2008; 28 (11): 783-7.
Zhao L., Zhang H., Zheng Z., Huang J. Elecroacupuncture on the head points for improving gnosia in patients with vascular dementia. J. Tradit. Chin. Med. 2009; 29 (1): 29-34.
Chen Z.H., Lai X.S., Jiang G.H. Effects of electro-acupuncture on electroencephalography in patients with vascular dementia. Zhongguo Zhong Xi Yi Jie He ZaZhi. 2006; 26 (8): 738-40.
Chen Q., Huang H.M., Xu Y.J., Lu R.L., Zhou X.H., Zhou C. Controlled study of auricular point taping and pressing therapy for treatment of vascular dementia. Zhongguo Zhen Jiu. 2009; 29 (2): 95-7.
Zhou Y., Jin J. Effect of acupuncture given at the HT 7, ST 36, ST 40 and KI 3 acupoints on various parts of the brains of Alzheimer' s disease patients. Acupunct. Electrother. Res. 2008; 33 (1-2): 9-17.
Huang Y., Lai X.S., Tang A.W. Comparative study of the specificities of needling acupoints DU20, DU26 and HT7 in intervening vascular dementia in different areas in the brain on the basis of scale assessment and cerebral functional imaging. Chin. J. Integr. Med. 2007; 13 (2): 103-8.
Lai X.S., Huang Y. Comparative study on therapeutic effects of Baihui (GV 20), Shuigou (GV 26) and Shenmen (HT 7) in treatment of vascular dementia. Zhongguo Zhen Jiu. 2005; 25 (8): 559-63.
Luo W.P., Tan J.L., Huang H.Y. Clinical observation on treatment of cerebral infarction-induced broca aphasia by Tiaoshen Fuyin acupuncture therapy combined with language training. Zhongguo Zhen Jiu. 2008; 28 (3): 171-5.
Razumov A.N., Sharova L.V., Kravtsov Yu.I. The adaptive reserves of the organism and their correction with the supplication of bioinformation technologies. Monograph. Perm: PGPU; 2011. 298 p. [In Russ.].