Control of hormonal rhinitis symptoms in patients with hypothyrosis: pathogenetic and clinical aspects

Kryukov A.I.

Sverzhevsky Research Clinical Institute of Otorhinolaryngology;
Pirogov Russian National Research Medical University

ORCID: 0000-0002-0149-0676

Chernykh N.M.

Irkutsk State Medical University of the Ministry of Health of the Russian Federation

ORCID: 0000-0003-1303-5010

Nosulya E.V.

Sverzhevky Research Clinical Institute of Otorhinolaryngology

ORCID: 0000-0002-3897-8384

Kunelskaya N.L.

L. I. Sverzhevsky Research Clinical Institute of Otorhinolaryngology;
Pirogov Russian National Research Medical University

ORCID: 0000-0002-1001-2609

Kim I.A.

N.I. Pirogov Russian National Research Medical University;
National Medical Research Center of Otorhinolaryngology of Federal Medical-Biological Agency

ORCID: 0000-0003-1078-6388

Karnoukhova O.G.

Irkutsk State Medical University of the Ministry of Health of the Russian Federation

ORCID: 0000-0003-1026-8417

Control of hormonal rhinitis symptoms in patients with hypothyrosis: pathogenetic and clinical aspects

Authors:

Kryukov A.I., Chernykh N.M., Nosulya E.V., Kunelskaya N.L., Kim I.A., Karnoukhova O.G.

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Journal: Russian Bulletin of Otorhinolaryngology. 2023;88(4): 54‑60

DOI: 10.17116/otorino20228804154

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To cite this article:

Kryukov AI, Chernykh NM, Nosulya EV, Kunelskaya NL, Kim IA, Karnoukhova OG. Control of hormonal rhinitis symptoms in patients with hypothyrosis: pathogenetic and clinical aspects. Russian Bulletin of Otorhinolaryngology. 2023;88(4):54‑60. (In Russ.)
https://doi.org/10.17116/otorino20228804154

Подписка 2025-2 (Russian Bulletin of Otorhinolaryngology)

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BACKGROUND

One of the poorly studied sections of the pathology of ENT organs is chronic rhinitis in patients with hypothyroidism, the pathogenesis of which has not been fully understood, the diagnosis causes significant difficulties, and there are no recommendations for treatment. Despite receiving replacement therapy with levothyroxine, the symptoms of rhinitis persist.

OBJECTIVE

To study the effectiveness of the use of intranasal glucocorticosteroids in patients with chronic rhinitis and hypothyroidism.

MATERIAL AND METHODS

Patients with chronic rhinitis and hypothyroidism used mometasone nasal spray 100 mcg 1 time per day for a course of treatment of 2 months (n=60). To assess the symptoms of rhinitis, a visual analog scale (0—10 points), endoscopic examination of ENT organs, anterior active rhinomanometry were used. Evaluation of mucociliary transport was used a saccharin test. The concentration of transforming growth factor (TGF-β1) in nasal secretion and blood serum was studied by ELISA (Enzyme-Linked Immunosorbent Assay), the number of metabolites of NO — nitrites+nitrates (NO_x) was recorded by colorimetric method.

RESULTS

The use of mometasone nasal spray in patients with hypothyroidism helped to reduce complaints on a visual-analog scale (difficulty in nasal breathing, rhinorrhea) and improve nasal breathing according to anterior active rhinomanometry. The concentrations of TGF-β1 and NO_x in nasal secretions before mometasone treatment were higher than after treatment, which probably indicates the contribution of these substances to the formation of edematous hypertrophic changes from the nose in patients with hypothyroidism.

Keywords:

hypothyroidism

chronic rhinitis

intranasal glucocorticosteroids

transforming growth factor β1

nitric oxide

Authors:

Kryukov A.I.

Sverzhevsky Research Clinical Institute of Otorhinolaryngology;
Pirogov Russian National Research Medical University

ORCID: 0000-0002-0149-0676

Chernykh N.M.

Irkutsk State Medical University of the Ministry of Health of the Russian Federation

ORCID: 0000-0003-1303-5010

Nosulya E.V.

Sverzhevky Research Clinical Institute of Otorhinolaryngology

ORCID: 0000-0002-3897-8384

Kunelskaya N.L.

L. I. Sverzhevsky Research Clinical Institute of Otorhinolaryngology;
Pirogov Russian National Research Medical University

ORCID: 0000-0002-1001-2609

Kim I.A.

N.I. Pirogov Russian National Research Medical University;
National Medical Research Center of Otorhinolaryngology of Federal Medical-Biological Agency

ORCID: 0000-0003-1078-6388

Karnoukhova O.G.

Irkutsk State Medical University of the Ministry of Health of the Russian Federation

ORCID: 0000-0003-1026-8417

Received:

18.01.2022

Accepted:

25.05.2023

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