Nitrosative stress plays an important role in inflammatory diseases of the nasal cavity, therefore the study of its manifestations and the possibilities of its pharmacological correction remains relevant.

OBJECTIVE

To assess the state of nitrosative stress and effectiveness of antioxidant therapy in patients with inflammatory diseases of the nasal cavity.

PATIENTS AND METHODS

A total of 156 patients with inflammation of the nasal cavity, divided into 4 groups according to the factor which caused the inflammation and the treatment methods, were examined. The 1st and 2^nd groups included 36 patients with acute rhinosinusitis, the 3^rd (44 patients) and 4^th (40 patients) groups — patients after septoplasty and vasotomy. Subjects of the 2^nd and 4^th groups, in addition to standard treatment and topical administration of repairing agent into the nasal cavity, were complementary given an antioxidant — 15% solution of dimethyl ether of 1.1-dimethyl-3-oxybutyl phosphonic acid. Concentration of nitrates and nitrites was determined in the nasal secretion of patients at admission, on the 5^th, 10^th, 21^st day.

RESULTS

In the early observation stages of inflammation, an increase in the concentration of nitrogen oxide metabolites with subsequent depletion of the nitroxidergic system and a gradual decrease of their concentration below the control values have been noted. On the 5^th day, statistically significant difference was noted between the 1^st and 2^nd (p_1—2=0.0001), the 3^rd and 4^th (p_3—4=0.009) groups. In the 2^nd and 4^th groups, the concentration of nitrogen oxide metabolites did not exceed the control values.

CONCLUSIONS

Administration of antioxidant therapy in the early period reduced the appearance of nitrosative stress in patients with inflammatory diseases of the nasal cavity. In order to avoid a pronounced and long-lasting inhibition of nitrogen oxide production after administration of antioxidant therapy, which can have a negative effect on the epithelium regeneration, it is necessary to dynamically control the concentration of nitrogen oxide metabolites in the nasal secretion.