Non-contact optical coherence tomography — an effective method for visualizing the exudate of the middle ear

Novozhilov A.A.

Privolzhsky Regional Medical Center of the FMBA of Russia;
Institute of Applied Physics of RAS;
Privolzhsky Research Medical University

Shilyagin P.A.

Institute of Applied Physics of RAS

Abubakirov T.E.

Privolzhsky Regional Medical Center of the FMBA of Russia;
Institute of Applied Physics of RAS

DilenYan A.L.

Privolzhsky Regional Medical Center of the FMBA of Russia

Klimycheva M.B.

Privolzhsky Regional Medical Center of the FMBA of Russia

Gelikonov G.V.

Institute of Applied Physics of RAS

Ksenofontov S.Yu.

Institute of Applied Physics of RAS

Gelikonov V.M.

Institute of Applied Physics of RAS

Shakhov A.V.

Federal State Budgetary Educational Institution of Higher Education «Privolzhsky Research Medical University» of the Ministry of Health of the Russian Federation

Non-contact optical coherence tomography — an effective method for visualizing the exudate of the middle ear

Authors:

Novozhilov A.A., Shilyagin P.A., Abubakirov T.E., DilenYan A.L., Klimycheva M.B., Gelikonov G.V., Ksenofontov S.Yu., Gelikonov V.M., Shakhov A.V.

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Journal: Russian Bulletin of Otorhinolaryngology. 2020;85(4): 16‑23

DOI: 10.17116/otorino20208504116

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To cite this article:

Novozhilov AA, Shilyagin PA, Abubakirov TE, et al. . Non-contact optical coherence tomography — an effective method for visualizing the exudate of the middle ear. Russian Bulletin of Otorhinolaryngology. 2020;85(4):16‑23. (In Russ.)
https://doi.org/10.17116/otorino20208504116

Подписка 2025-2 (Russian Bulletin of Otorhinolaryngology)

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INTRODUCTION

Otitis media with effusion (OME) accounts for 15-17% of the total number of recorded diseases of the middle ear. Surgical methods have become much more common. One of the factors affecting the tactics and effectiveness of treatment OME is the degree of viscosity of the effusion. Modern diagnostic methods do not allow to reliably identify cases of OME with high effusion viscosity.

OBJECTIVE

To study the possibilities of optical coherence tomography (OCT) in the diagnosis of OME and a non-invasive study of effusion viscosity.

MATERIAL AND METHODS

An analysis of the results of the examination of 29 patients who underwent surgical treatment for OME — tympanostomy. A control group of 30 patients without middle ear pathology. The study used a spectral OCT with a non-contact probe designed specifically for studies of the structural middle ear. Quantitative analysis of the results using open source ImageJ. Objectification of the degree of viscosity of the effusion was carried out by means of viscometry. A comparative analysis of the intensity of the optical signal in the external auditory canal (EAC) and in the tympanic cavity (TC) was performed, as well as a comparison of the signal from viscous and fluid effusion.

RESULTS

In all patients with OME, during the OCT study, an optical signal with a higher intensity was recorded in TC than in the EAC. In all cases, in the control group in the TC, an optical signal was recorded that was identical in intensity with the signal in the EAC. When measuring the degree of viscosity of the effusion, 17 cases of OME were characterized as effusion of a low degree of viscosity, 12 cases — effusion of extreme viscosity. When comparing the average intensity of the optical signal of the OCT images of viscous and liquid effusion, a statistically significant difference was revealed, p<0.001.

DISCUSSION

OCT makes it possible to detect light scattering from large scatterers — cell structures characteristic of low viscosity effusion. In addition, OCT allows you to register an optical signal from small scatterers — high molecular weight structures that are present in large quantities in viscous effusion. A correlation was found between the intensity of the optical signal in the TC and the degree of viscosity of the middle ear effusion.

CONCLUSIONS

Based on OCT data, it is possible to determine the indications for surgical treatment of OME by detecting viscous exudate.

Keywords:

otitis media with effusion

optical coherence tomography

diagnostic methods

Authors:

Novozhilov A.A.

Privolzhsky Regional Medical Center of the FMBA of Russia;
Institute of Applied Physics of RAS;
Privolzhsky Research Medical University

Shilyagin P.A.

Institute of Applied Physics of RAS

Abubakirov T.E.

Privolzhsky Regional Medical Center of the FMBA of Russia;
Institute of Applied Physics of RAS

DilenYan A.L.

Privolzhsky Regional Medical Center of the FMBA of Russia

Klimycheva M.B.

Privolzhsky Regional Medical Center of the FMBA of Russia

Gelikonov G.V.

Institute of Applied Physics of RAS

Ksenofontov S.Yu.

Institute of Applied Physics of RAS

Gelikonov V.M.

Institute of Applied Physics of RAS

Shakhov A.V.

Federal State Budgetary Educational Institution of Higher Education «Privolzhsky Research Medical University» of the Ministry of Health of the Russian Federation

Received:

15.10.2019

Accepted:

09.06.2020

List of references:

Gultekin E, Develioğlu ON, Yener M, Ozdemir I, Külekçi M. Prevalence and risk factors for persistent otitis media with effusion in primary school children in Istanbul, Turkey. Auris Nasus Larynx. 2010;37(2):145-149. https://doi.org/10.1016/j.anl.2009.05.002
Apostolopoulos K, Xenelis J, Tzagaroulakis A, Kandiloros D, Yiotakis J, Papafragou K. The point prevalence of otitis media with effusion among school children in Greece. Int J Pediatr Otorhinolaryngol. 1998;44(3):207-214. https://doi.org/10.1016/s0165-5876(98)00002-0
Rushton HC, Tong MC, Yue V, Wormald PJ, van Hasselt CA. Prevalence of otitis media with effusion in multicultural schools in Hong Kong. J Laryngol Otol. 1997;111(9):804-806. https://doi.org/10.1017/s002221510013868x
Holmquist J, Al Fadala S, Qattan Y. Prevalence of secretory otitis media among school children in Kuwait. J Laryngol Otol. 1987; 101(2):116-119. https://doi.org/10.1017/s0022215100101367
Okur E, Yildirim I, Akif Kilic M, Guzelsoy S. Prevalence of otitis media with effusion among primary school children in Kahramanmaras, in Turkey. Int J Pediatr Otorhinolaryngol. 2004;68(5): 557-562. https://doi.org/10.1016/j.ijporl.2003.12.014
Stratieva OV, Arefieva NA. One-stage and step-by-step nose and ear surgery in the treatment of seromucoid otits. Novosti otorinilaringologii i logopatologii. 1998;4:93-94. (In Russ.)
Arbesman C.E. Secretory otitis media. A review. Acta Otorhinolaryngol Belg. 1979;33(4):464-473.
Alderson D. The glue ear ‘epidemic’: a historical perspective. Med Humanit. 2011;37(2):110-114. https://doi.org/10.1136/jmh.2011.007039
Black N. Causes of glue ear. An historical review of theories and evidence. J Laryngol Otol. 1985;99(10):953-966. https://doi.org/10.1017/s0022215100098005
Takeuchi K, Majima Y, Hirata K, Morishita A, Hattori M, Sakakura Y. Prognosis of secretory otitis media in relation to viscoelasticity of effusions in children. Ann Otol Rhinol Laryngol. 1989; 98(6):443-446. https://doi.org/10.1177/000348948909800609
Takeuchi K, Majima Y, Hirata K, Morishita A, Hattori M, Sakakura Y. Viscoelastic properties of middle ear effusions from pediatric otitis media with effusion and their relation to gross appearance. Eur Arch Otorhinolaryngol. 1990;247(1):60-62. https://doi.org/10.1007/bf00240953
Honjo I, Hayashi M, Ito S, Takahashi H. Pumping and clearance function of the eustachian tube. Am J Otolaryngol. 1985;6(3):241-244. https://doi.org/10.1016/s0196-0709(85)80095-8
Novozhilov AA, Shilyagin PA, Shakhov AV, Gelikonov VM. Overview of modern methods of the diagnosis of otitis media with effusion. Vestnik otorinolaringologii. 2020. (In Russ.)
Boppart SA. Optical coherence tomography: technology and applications for neuroimaging. Psychophysiology. 2003;40(4):529-541. https://doi.org/10.1111/1469-8986.00055
Adhi M, Duker JS. Optical coherence tomography — current and future applications. Curr Opin Ophthalmol. 2013;24(3):213-221. https://doi.org/10.1097/ICU.0b013e32835f8bf8.
Rubinstein M, Schalch P, Di Silvio M, Betancourt MA, Wong BJ. Optical coherence tomography applications in otolaryngology. Acta Otorrinolaringol Esp. 2009;60(5):357-363. https://doi.org/10.1016/j.otorri.2008.12.003
Djalilian HR, Rubinstein M, Wu EC, Naemi K, Zardouz S, Karimi K, Wong BJ. Optical coherence tomography of cholesteatoma. Otol Neurotol. 2010;31(6):932-935. https://doi.org/10.1097/mao.0b013e3181e711b8
Pitris C, Saunders KT, Fujimoto JG, Brezinski ME. High-resolution imaging of the middle ear with optical coherence tomography: a feasibility study. Arch Otolaryngol Head Neck Surg. 2001; 127(6):637-642. https://doi.org/10.1001/archotol.127.6.637
Monroy GL, Pande P, Nolan RM, Shelton RL, Porter RG, Novak MA, Spillman DR, Chaney EJ, McCormick DT, Boppart SA. Noninvasive in vivo optical coherence tomography tracking of chronic otitis media in pediatric subjects after surgical intervention. J Biomed Opt. 2017;22(12):1-11. https://doi.org/10.1117/1.JBO.22.12.121614
Novozhilov AA, Shilyagin PA, Abubakirov TE, Khasyanova YuA, Shakhov AV, Gelikonov VM. The possibilities of optical coherence tomography in the diagnosis of otitis media with effusion. Rossijskaya otorinolaringologiya. 2018;2(93):66-71. (In Russ.) https://doi.org/10.18692/1810-4800-2018-2-66-71
Novozhilov AA, Shakhov AV. Optical coherence tomography in the diagnosis of otitis media with effusion. Folia otorhinolaringologica. 2016;22(2):46-47.
Meller AE, Shakhova MA, Rilkin YA, Novozhilov AA, Kirillin MA, Shakhov AV. Optical coherence tomography in diagnosing inflammatory diseases of ENT. Photonics & Lasers in Medicine. 2014; 3(4):323-330. https://doi.org/10.1515/plm-2014-0025
Preciado D, Nolan RM, Joshi R, Krakovsky GM, Zhang A, Pudik NA, Kumar NK, Shelton RL, Boppart SA, Bauman NM. Otitis Media Middle Ear Effusion Identification and Characterization Using an Optical Coherence Tomography Otoscope. Otolaryngol Head Neck Surg. 2020;194599819900762. https://doi.org/10.1177/0194599819900762
Shilyagin PA, Novozhilov AA, Abubakirov TE, Gelikonov GV, Shakhov AV, Gelikonov VM. Optical coherence tomography in otitis media with effusion diagnosing. Proceedings of SPIE. 2019; 11078:110780R. https://doi.org/10.1117/12.2527147
Shilyagin PA, Novozhilov AA, Abubakirov TE, Gelikonova VG, Terpelov DA, Matkivsky VA, Gelikonov GV, Shakhov AV, Gelikonov VM. Time domain optical coherence tomography is a useful tool for diagnosing otitis media with effusion. Laser Physics Letters. 2018;15(9):096201-5. https://doi.org/10.1088/1612-202X/aacb4c
Val S, Poley M, Anna K, Nino G, Brown K, Pérez-Losada M, Gordish-Dressman H, Preciado D. Characterization of mucoid and serous middle ear effusions from patients with chronic otitis media: implication of different biological mechanisms? Pediatric research. 2018;84(2):296-305. https://doi.org/10.1038/s41390-018-0060-6
Seth R, Discolo CM, Palczewska GM, Lewandowski JJ, Krakovitz PR. Ultrasound characterization of middle ear effusion. American journal of otolaryngology. 2013;34(1):44-50. https://doi.org/10.1016/j.amjoto.2012.08.005
Matkovic S, Vojvodic D, Baljosevic I. Cytokine levels in groups of patients with different duration of chronic secretory otitis. Eur Arch Otorhinolaryngol. 2007;264(11):1283-1287. https://doi.org/10.1007/s00405-007-0373-2
Krueger A, Val S, Pérez-Losada M, Panchapakesan K, Devaney J, Duah V, DeMason C, Poley M, Rose M, Preciado D. Relationship of the Middle Ear Effusion Microbiome to Secretory Mucin Production in Pediatric Patients With Chronic Otitis Media. Pediatr Infect Dis J. 2017;36(7):635-640. https://doi.org/10.1097/INF.0000000000001493.
Radicioni G, Cao R, Carpenter J, Ford AA, Wang T, Li L, Kesimer M. The innate immune properties of airway mucosal surfaces are regulated by dynamic interactions between mucins and interacting proteins: the mucin interactome. Mucosal Immunol. 2016;9(6):1442-1454. https://doi.org/10.1038/mi.2016.27
Rose MC, Voynow JA. Respiratory tract mucin genes and mucin glycoproteins in health and disease. Physiol Rev. 2006;86(1): 245-278. https://doi.org/10.1152/physrev.00010.2005
Chung MH, Choi JY, Lee WS, Kim HN, Yoon JH. Compositional difference in middle ear effusion: mucous versus serous. Laryngoscope. 2002;112(1):152-155. https://doi.org/10.1097/00005537-200201000-00027
Bhutta MF, Thornton RB, Kirkham LS, Kerschner JE, Cheeseman MT. Understanding the aetiology and resolution of chronic otitis media from animal and human studies. Disease models & mechanisms. 2017;10(11):1289-1300. https://doi.org/10.1242/dmm.029983
Piskunov SZ, Zavyalov FN, Salikov AV, Popova LP. The value of cytological examenation of the effusion in diagnosis and treatment of otitis media with effusion. Rossijskaya otorinolaringologiya. 2008;5(36):122-129. (In Russ.)
Gelikonov GV, Ksenofontov SYu, Shilyagin PA, Gelikonov VM. Compensation for the Influence of Fluctuations in the Distance to the Object During Noncontact Probing in Spectral Domain Optical Coherence Tomography. Radiophys Quantum El. 2019;62(3):252-262. (In Russ.) https://doi.org/10.1007/s11141-019-09971-0

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