Laryngeal papillomatosis: problem update

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The objective of the present roverview was to analyse the available data on etiology, pathogenesis, diagnostics, and treatment of laryngeal papillomatosis. It is shown that the pathogenetic mechanism underlying the development of this pathology is related to cell proliferation mechanisms. The human papilloma virus is most effectively identified by the polymerase chain reaction technique in combination with in situ hybridization. It is expected that new and more informative criteria for diagnostics, treatment, and prognosis of laryngeal papillomatosis will be proposed based on recent progress in molecular biology, morphology, and immunology. Different variants of the therapeutic strategy for the treatment of laryngeal papillomatosis are described. Modern practice of the management of laryngeal papillomatosis takes advantage of the three main approaches and/or their combination. First, further improvement of surgical techniques, such as the application of endoscopic devices and surgical lasers. Second, the search for new pharmaceutical agents (indole-3-carbinol, cidofovir, antiviral medicines, etc.) most frequently used for adjuvant therapy. Third, the development of new vaccination methods. Besides these three approaches, photodynamic therapy and the use of ionizing radiation are currently being studied as the tools for the treatment of extensive and recurrent laryngeal papillomatosis as well as the methods of laser-induced interstitial thermotherapy.

Keywords:

laryngeal papillomatosis

human papilloma virus

immunohistochemical analysis

polymerase chain reaction

endoscopic surgery

antiviral therapy

radiation therapy

Authors:

Svistushkin V.M.

LOR-klinika Moskovskogo oblastnogo nauchno-issledovatel'skogo klinicheskogo instituta im. M.F. Vladimirskogo, Moskva

Mustafaev D.M.

LOR-klinika Moskovskogo oblastnogo nauchno-issledovatel'skogo klinicheskogo instituta im. M.F. Vladimirskogo, Moskva

List of references:

Antoniv V.F., Mitskonas A., Antoniv T.V., Matela I.I. Papillomatoz gortani. Rol' virusa papillomy cheloveka, perspektivy diagnostiki i lecheniya. Vestn otorinolar 2004; 3: 23-26.
Ashurov Z.M., Zenger V.G. Respiratornyi papillomatoz u detei. M: Media Sfera 2004.
Baryshev V.V., Andreev V.G., Popuchiev V.V., Ezhov S.V. Sovremennye aspekty izucheniya respiratornogo papillomatoza. Chast' I. Etiologiya, patogenez, diagnostika. Sib onkol zhurn 2009; 5: 35: 67-72.
Ivanchenko G.F., Karimova F.S. Sovremennye predstavleniya ob etiologii, patogeneze, klinike, diagnostike i lechenii papillomatoza gortani. Vestn otorinolar 2000; 1: 44-49.
Soldatskii Yu.L., Kiselev V.I., Onufrieva E.K., Steklov A.M., Shchepin N.V., Strygina Yu.V., Gasparyan S.F., Pogosova I.E. Analiz effektivnosti protivoretsidivnoi terapii yuvenil'nogo respiratornogo papillomatoza pri pomoshchi indinola. Vestn otorinolar 2006; 1: 46-48.
Shabaldina E.V., Pavlenko S.A., Shabaldin A.V. Yuvenil'nyi respiratornyi papillomatoz gortani. Meditsina v Kuzbasse 2006; 3: 32-34.
Katsenos S., Becker H.D. Recurrent respiratory papillomatosis: a rare chronic disease, difficult to treat, with potential to lung cancer transformation: apropos of two cases and a brief literature review. Case Rep Oncol 2011; 4: 1: 162-171.
Kashima H.K., Mounts P., Shah K. Recurrent respiratory papillomatosis. Obstet Gynecol Clin North Am 1996; 23: 3: 699-706.
Chireshkin D.G. Papillomatoz gortani u detei (Materialy k patogenezu, klinike i lecheniyu): Avtoref. dis. … d-ra med. nauk. M 1971.
Vozhagov V.V. Gol'mievyi lazer i leikomaks v kompleksnom lechenii respiratornogo papallomatoza u detei: Avtoref. dis. … kand. med. nauk. M 1999.
Pluzhnikov M.S., Ryabova M.A., Karpishchenko S.A. Sovremennye podkhody k kombinirovannomu lecheniyu retsidiviruyushchego respiratornogo papillomatoza. Vestn otorinolar 2008; 4: 29-37.
Gordjani N., Herdeg S., Ross U.H., Grimme H., Kleinschmidt M., Brandis M. Focal dermal hypoplasia (Goltz-Gorlin syndrome) associated with obstructive papillomatosis of the larynx and hypopharynx. Eur J Dermatol 1999; 9: 8: 618-620.
Selin V.N. Endolaringeal'naya mikrokhirurgiya i ul'trazvukovaya dezintegratsiya papillom gortani u detei: Avtoref. dis. … kand. med. nauk. M 1988.
Soldatskii Yu.L., Onufrieva E.K., Strygina Yu.V., Pogosova I.E. Retsidiviruyushchii respiratornyi papillomatoz: sovremennoe sostoyanie problemy. Ros otorinolar 2009; 4: 66-71.
Bondaryev A., Makris D., Breen D.P., Dutau H. Airway Stenting for severe endobronchial papillomatosis. Respiration 2009; 77: 4: 455-458.
Skoulas I.G., Kountakis S.E. Endotracheal tube obstruction: a rare complication in laser ablation of recurrent laryngeal papillomas. Ear Nose Throat J 2003; 82: 7: 504-512.
Somers G.R., Tabrizi S.N., Borg A.J., Garland S.M., Chow C.W. Juvenile laryngeal papillomatosis in a pediatric population: a clinicopathologic study. Pediatr Pathol Lab Med 1997; 17: 1: 53-64.
Carney A.S., Evans A.S., Mirza S., Psaltis A. Radiofrequency coblation for treatment of advanced laryngotracheal recurrent respiratory papillomatosis. J Laryngol Otol 2010; 124: 5: 510-514.
Sidorenko S.I. Oslozhnennoe techenie yuvenil'nogo respiratornogo papillomatoza. Vestn otorinolar 2005; 6: 62-63.
Ovchinnikov Yu.M., Kiselev V.I., Soldatskii Yu.L., Artem'ev M.I., Onufrieva E.K., Baranovskii P.M., Shchepin N.V., Smetanina S.E., Gasparyan S.F., Steklov A.M. Rasprostranennost' tipov virusa papillomy cheloveka i ikh vliyanie na techenie zabolevaniya u detei, stradayushchikh retsidiviruyushchim respiratornym papillomatozom. Vestn otorinolar 2004; 3: 29-33.
Soldatskii Yu.L., Onufrieva E.K., Pogosova I.E., Strygina Yu.V., Dyudya A.V. Infitsirovannost' virusom papillomy cheloveka verkhnikh dykhatel'nykh putei u detei bez klinicheskikh priznakov respiratornogo papillomatoza. Vestn otorinolar 2009; 1: 16-19.
Shilova O.Yu. Assotsiatsiya raka gortani s onkogennymi virusami papillomy cheloveka i Epshteina-Barr: Avtoref. dis. … kand. med. nauk. Novosibirsk 2008.
Zur Hausen H., de Villiers E.M. Human papillomaviruses. Ann Rev Microbiol 1994; 48: 427-447.
Gomez M.A., Drut R., Lojo M.M., Drut R.M. Detection of human papillomavirus in juvenile laryngeal papillomatosis using polymerase chain reaction. Medicina (B. Aires) 1995; 55: 3: 213-217.
Xavier R., Santos G., Medeiros R. Perinatal transmission of human papilloma virus. 7th Intern Congr Pediat Otorhinolaryngology. Helsinki 1998; 210.
Baryshev V.V., Andreev V.G., Popuchiev V.V., Ezhov S.V. Sovremennye aspekty izucheniya respiratornogo papillomatoza. Chast' II. Lechenie. Sib onkol zhurn 2010; 1: 37: 68-72.
Akyol A., Anadolu R., Anadolu Y., Ekmekci P., Gürgey E., Akay N. Multifocal papillomavirus epithelial hyperplasia: successful treatment with CO2 laser therapy combined with interferon alpha-2b. Int J Dermatol 2003; 42: 9: 733-735.
Bergler W., Honig M., Gotte K., Petroianu G., Hörmann K. Treatment of recurrent respiratory papillomatosis with argon plasma coagulation. J Laryngol Otol 1997; 111: 381-384.
Karpishchenko S.A., Gur'eva I.A. Metodika lazerindutsirovannoi interstitsial'noi termoterapii v khirurgicheskom lechenii respiratornogo papillomatoza. Vestn otorinolar 2008; 4: 62-67.
Andreev V.G., Pankratov V.A. Luchevoe i kombinirovannoe lechenie papillomatoza gortani. Med radiol 1992; 11-12: 5-8.
Pankratov V.A., Andreev V.G., Shaimbetov B.O., Romanko Yu.S. Znachenie luchevoi terapii v lechenii papillomatoza gortani. Opukholi golovy i shei. Diagnostika i lechenie. Tomsk 1994; 106-108.
Karimova F.S., Ivanchenko G.F., Grigoryan S.S. Lechenie papillomatoza gortani induktorami interferona. Vestn otorinolar 2000; 5: 54-57.
Kozlova E.P. Kompleksnoe lechenie papillomatoza gortani s primeneniem indol-3-karbinola: Avtoref. dis. … kand. med. nauk. SPb 2009.
Pluzhnikov M.S., Katinas E.B., Ryabova M.A. Otsenka effektivnosti mestnogo primeneniya preparatov rekombinantnogo interferona α-2 v kompleksnoi terapii retsidiviruyushchego respiratornogo papillomatoza. Vestn otorinolar 2008; 4: 57-61.
Rafal'skii V.V. Klinicheskoe primenenie preparatov interferona. Smolensk: SGMA 1997.
Tsvetkov E.A., Sel'kov S.A., Chmyreva N.N. Interferonoterapiya i immunoterapiya detei s respiratornym papillomatozom. Vestn otorinolar 2002; 2: 34-36.
Akst L.M., Lee W., Discolo C., Knott D., Younes A., Koltai P.J. Stepped-dose protocol of cidofovir therapy in recurrent respiratory papillomatosis in children. Arch Otolaryngol Head Neck Surg 2003; 129: 8: 841-846.
Snoeck R., Wellens W., Desloovere C., van Ranst M., Naesens L., De Clercq E., Feenstra L. Treatment of severe laryngeal papillomatosis with intralesional injections of cidofovir [(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine]. J Med Virol 1998; 54: 3: 219-225.
Valera F., Maldonato L., Lima J. Efficacy of cidofovir in recurrent juvenile respiratory papillomatosis. Braz J Otorhinolar 2010; 76: 6: 713-717.
Rosen C.A., Bryson P.C. Indole-3-carbinol for recurrent respiratory papillomatosis: long-term results. J Voice 2004; 18: 2: 248-253.
Shikowitz M.J., Abramson A.L., Steinberg B.M., DeVoti J., Bonagura V.R., Mullooly V., Nouri M., Ronn A.M., Inglis A., McClay J., Freeman K. Clinical trial of photodynamic therapy with meso-tetra (hydroxyphenyl) chlorine for respiratory papillomatosis. Arch Otolaryngol Head Neck Surg 2005; 131: 2: 99-105.
Sokolov V.V., Telegina L.V., Gladyshev A.A., Telegina L.V., Filonenko E.V., Reshetov I.G., Golubtsov A.K., Frank G.A., Belous T.A., Zavalishina L.E. Endolaringeal'naya khirurgiya i fotodinamicheskaya terapiya s ispol'zovaniem gibkoi videoendoskopicheskoi tekhniki pri predrake i rake gortani. Vestn otorinolar 2010; 3: 50-56.

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