Laryngeal papillomatosis: problem update

Svistushkin V.M.; Mustafaev D.M.

doi:https://doi.org/

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Abstract:

The objective of the present roverview was to analyse the available data on etiology, pathogenesis, diagnostics, and treatment of laryngeal papillomatosis. It is shown that the pathogenetic mechanism underlying the development of this pathology is related to cell proliferation mechanisms. The human papilloma virus is most effectively identified by the polymerase chain reaction technique in combination with in situ hybridization. It is expected that new and more informative criteria for diagnostics, treatment, and prognosis of laryngeal papillomatosis will be proposed based on recent progress in molecular biology, morphology, and immunology. Different variants of the therapeutic strategy for the treatment of laryngeal papillomatosis are described. Modern practice of the management of laryngeal papillomatosis takes advantage of the three main approaches and/or their combination. First, further improvement of surgical techniques, such as the application of endoscopic devices and surgical lasers. Second, the search for new pharmaceutical agents (indole-3-carbinol, cidofovir, antiviral medicines, etc.) most frequently used for adjuvant therapy. Third, the development of new vaccination methods. Besides these three approaches, photodynamic therapy and the use of ionizing radiation are currently being studied as the tools for the treatment of extensive and recurrent laryngeal papillomatosis as well as the methods of laser-induced interstitial thermotherapy.

Keywords:

laryngeal papillomatosis

human papilloma virus

immunohistochemical analysis

polymerase chain reaction

endoscopic surgery

antiviral therapy

radiation therapy

Authors:

Svistushkin V.M.

LOR-klinika Moskovskogo oblastnogo nauchno-issledovatel'skogo klinicheskogo instituta im. M.F. Vladimirskogo, Moskva

Mustafaev D.M.

LOR-klinika Moskovskogo oblastnogo nauchno-issledovatel'skogo klinicheskogo instituta im. M.F. Vladimirskogo, Moskva

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