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Demenkov V.R.

Kafedra otorinolaringologii Luganskogo gosudarstvennogo meditsinskogo universiteta

Frolov V.M.

Kafedra obshcheĭ khirurgii i kafedra infektsionnykh bolezneĭ s épidemiologieĭ Luganskogo gosudarstvennogo meditsinskogo universiteta

Peresadin N.A.

Kafedra obshcheĭ khirurgii i kafedra infektsionnykh bolezneĭ s épidemiologieĭ Luganskogo gosudarstvennogo meditsinskogo universiteta

Kruglova O.V.

Kafedra infektsionnykh bolezneĭ s épidemiologieĭ Luganskogo gosudarstvennogo meditsinskogo universiteta;
Otdel ékologicheskoĭ genetiki i klinicheskoĭ immunologii Ukrainskogo nauchnogo tsentra meditsinskoĭ genetiki NAN, ­Lugansk

Influence of сycloferon on the сytokine blood profile and production of proinflammatory сytokines in the cultures of mononucleares of peripheral blood of the patients with chronic tonsillitis

Authors:

Demenkov V.R., Frolov V.M., Peresadin N.A., Kruglova O.V.

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Journal: Russian Bulletin of Otorhinolaryngology. 2012;77(4): 73‑76

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INFLUENCE OF СYCLOFERON ON THE СYTOKINE BLOOD PROFILE AND PRODUCTION OF PROINFLAMMATORY СYTOKINES IN THE CULTURES OF MONONUCLEARES OF PERIPHERAL BLOOD OF THE PATIENTS WITH CHRONIC TONSILLITIS
INFLUENCE OF СYCLOFERON ON THE СYTOKINE BLOOD PROFILE AND PRODUCTION OF PROINFLAMMATORY СYTOKINES IN THE CULTURES OF MONONUCLEARES OF PERIPHERAL BLOOD OF THE PATIENTS WITH CHRONIC TONSILLITIS

To cite this article:

Demenkov VR, Frolov VM, Peresadin NA, Kruglova OV. Influence of сycloferon on the сytokine blood profile and production of proinflammatory сytokines in the cultures of mononucleares of peripheral blood of the patients with chronic tonsillitis. Russian Bulletin of Otorhinolaryngology. 2012;77(4):73‑76. (In Russ.)

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The 88 patients with chronic tonsillitis (CT) was investigated. The 46 patients (basic group) got the modern immunoactive preparation cycloferon and 42 patients (comparison group) - only the generally accepted therapy. During immunological researches on a background clinical manifestation of СT the increase proinflammatory cytokines (CK) (TNFα, IL-1Β) in the serum, and also increase the level of spontaneous products of these CK in the cultures mononucleares of periferal blood was detected. At general accepted treatment took place increase level proinflammatory CK at serum on background decline stimulated product of CK at mononucleares cultures. Aрplication of cycloferon at the treatment of CT provided to normalization cytokines profile of the blood and production of CK in the cultures mononucleares.

Keywords:

chronic tonsillitis
cytokines
production
mononucleares cultures
cycloferon
treatment

Authors:

Demenkov V.R.

Kafedra otorinolaringologii Luganskogo gosudarstvennogo meditsinskogo universiteta

Frolov V.M.

Kafedra obshcheĭ khirurgii i kafedra infektsionnykh bolezneĭ s épidemiologieĭ Luganskogo gosudarstvennogo meditsinskogo universiteta

Peresadin N.A.

Kafedra obshcheĭ khirurgii i kafedra infektsionnykh bolezneĭ s épidemiologieĭ Luganskogo gosudarstvennogo meditsinskogo universiteta

Kruglova O.V.

Kafedra infektsionnykh bolezneĭ s épidemiologieĭ Luganskogo gosudarstvennogo meditsinskogo universiteta;
Otdel ékologicheskoĭ genetiki i klinicheskoĭ immunologii Ukrainskogo nauchnogo tsentra meditsinskoĭ genetiki NAN, ­Lugansk

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