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Boiko E.V.

Saint Petersburg branch of S.N. Fedorov National Medical Research Center “MNTK “Eye Microsurgery”, Saint Petersburg, Russia;
North-Western State Medical University named after I.I. Mechnikov, Saint Petersburg, Russia;
Saint Petersburg State University, Saint Petersburg, Russia

Karev V.E.

Saint Petersburg State University, Saint Petersburg, Russia;
Federal Scientific and Clinical Center for Infectious Diseases of the Federal Medical and Biological Agency, Saint Petersburg, Russia

Pozniak A.L.

North-Western State Medical University named after I.I. Mechnikov, Saint Petersburg, Russia

Akhmedzhanov T.R.

Saint Petersburg branch of S.N. Fedorov National Medical Research Center “MNTK “Eye Microsurgery”, Saint Petersburg, Russia;
North-Western State Medical University named after I.I. Mechnikov, Saint Petersburg, Russia

Sidorchuk S.N.

S.M. Kirov Military Medical Academy, Saint Petersburg, Russia

Chronic conjunctivitis as an extragenital focus of genitourinary chlamydial infection

Authors:

Boiko E.V., Karev V.E., Pozniak A.L., Akhmedzhanov T.R., Sidorchuk S.N.

More about the authors

Journal: Russian Annals of Ophthalmology. 2026;142(1): 95‑100

DOI: 10.17116/oftalma202614201195

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Table of contents

CHRONIC CONJUNCTIVITIS AS AN EXTRAGENITAL FOCUS OF GENITOURINARY CHLAMYDIAL INFECTION
CHRONIC CONJUNCTIVITIS AS AN EXTRAGENITAL FOCUS OF GENITOURINARY CHLAMYDIAL INFECTION

To cite this article:

Boiko EV, Karev VE, Pozniak AL, Akhmedzhanov TR, Sidorchuk SN. Chronic conjunctivitis as an extragenital focus of genitourinary chlamydial infection. Russian Annals of Ophthalmology. 2026;142(1):95‑100. (In Russ.)
https://doi.org/10.17116/oftalma202614201195

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Chlamydial conjunctivitis accounts for 3 to 30% cases of conjunctivitis of various etiologies. In such patients, latent clinical manifestations do not correspond to morphological changes in the infected organs and tissues. This paper presents the results of a comprehensive examination of a patient with chronic chlamydial conjunctivitis in the setting of a disseminated form of chlamydial infection (DCI). Direct immunofluorescence (DIF) and polymerase chain reaction (PCR) were used for diagnostics. In addition, conjunctival biopsy specimens were obtained for immunohistochemical (IHC) analysis. Chlamydiae were detected in the conjunctiva, in blood and in clinical materials from the urogenital tract using PCR and DIF. IHC analysis showed that Chlamydia trachomatis was detected to a lesser extent in conjunctival epithelial cells and to a greater extent in endothelial cells of the inner lining of capillaries, mainly in the deep sections. Conjunctival biopsy allows obtaining a pathomorphological picture of tissues infected with chlamydia, providing objective confirmation of the etiopathogenetic role of this pathogen in the development of chronic inflammatory processes in the conjunctiva. An important laboratory diagnostic criterion of DCI is the detection of chlamydiae in peripheral blood neutrophils, as well as in endothelial cells of conjunctival capillaries.

Keywords:

chlamydial conjunctivitis
immunohistochemistry
laboratory diagnostics
chronic inflammation
urogenital chlamydial infection

Authors:

Boiko E.V.

Saint Petersburg branch of S.N. Fedorov National Medical Research Center “MNTK “Eye Microsurgery”, Saint Petersburg, Russia;
North-Western State Medical University named after I.I. Mechnikov, Saint Petersburg, Russia;
Saint Petersburg State University, Saint Petersburg, Russia

Karev V.E.

Saint Petersburg State University, Saint Petersburg, Russia;
Federal Scientific and Clinical Center for Infectious Diseases of the Federal Medical and Biological Agency, Saint Petersburg, Russia

Pozniak A.L.

North-Western State Medical University named after I.I. Mechnikov, Saint Petersburg, Russia

Akhmedzhanov T.R.

Saint Petersburg branch of S.N. Fedorov National Medical Research Center “MNTK “Eye Microsurgery”, Saint Petersburg, Russia;
North-Western State Medical University named after I.I. Mechnikov, Saint Petersburg, Russia

Sidorchuk S.N.

S.M. Kirov Military Medical Academy, Saint Petersburg, Russia

Received:

28.02.2025

Accepted:

25.05.2025

Close metadata

References:

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  2. Vakhova ES, Krichevskaya GI, Yani EV, Svetlova EV. Current aspects of Chlamydia trachomatis infection of the anterior eye segment: pathogenesis, clinical forms, laboratory diagnosis, treatment. Russian Ophthalmological Journal = Rossijskij oftal’mologicheskij zhurnal. 2014;7(4):5-12. (In Russ.).
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  11. Boiko EV, Pozniak AL, Ageev VS, Sidorchuk SN, Hlopunova OV. Oftal’mokhlamidioz u lits molodogo vozrasta: ehtiologiya, patogenez, klinicheskie formy, diagnostika (obzor literatury). Russian Annals of Ophthalmology = Vestnik oftal’mologii. 2008;1:50-53. (In Russ.).
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