The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Malyugin B.E.

S.N. Fedorov National Medical Research Center “MNTK “Eye Microsurgery”;
A.I. Yevdokimov Moscow State University of Medicine and Dentistry

Isabekov R.S.

S.N. Fedorov National Medical Research Center “MNTK “Eye Microsurgery”

Kalinnikova S.Yu.

The S.N. Fedorov National Medical Research Center “MNTK “Eye Microsurgery”

Antonova O.P.

S.N. Fedorov National Medical Research Center “MNTK “Eye Microsurgery”

Methods of diagnosis and treatment of corneal neovascularization

Authors:

Malyugin B.E., Isabekov R.S., Kalinnikova S.Yu., Antonova O.P.

More about the authors

Journal: Russian Annals of Ophthalmology. 2023;139(4): 86‑92

DOI: 10.17116/oftalma202313904186

Read: 2904 times

Download PDF (RU)
Contact the author
Table of contents

METHODS OF DIAGNOSIS AND TREATMENT OF CORNEAL NEOVASCULARIZATION
METHODS OF DIAGNOSIS AND TREATMENT OF CORNEAL NEOVASCULARIZATION

To cite this article:

Malyugin BE, Isabekov RS, Kalinnikova SYu, Antonova OP. Methods of diagnosis and treatment of corneal neovascularization. Russian Annals of Ophthalmology. 2023;139(4):86‑92. (In Russ.)
https://doi.org/10.17116/oftalma202313904186

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Iris mela­noma: correlation of clinical, morphometric, pathomorphological features and infe­ctious status. Russian Annals of Ophthalmology. 2025;(1):13-20
Primary angle closure suspects: application of machine learning method for substantiation of close moni­toring. Russian Annals of Ophthalmology. 2025;(2):67-74
Modern possibilities of using photodynamic therapy with an intravenous sensitizer as an alte­rnative to surgical treatment: a clinical case of successful. Russian Journal of Human Reproduction. 2024;(6):149-155
Effect of pro-inflammatory cyto­kines TNF-a and IL-1b on endo­thelial cells. Russian Cardiology Bulletin. 2024;(4-2):121-127
Photodynamic inactivation of anti­biotic-resistant microflora of gunshot wounds under fluorescence control. Piro­gov Russian Journal of Surgery. 2025;(2):50-59
Gender specificity of angiogenesis in patients with non-muscle inva­sive bladder cancer complicated by type 2 diabetes mellitus. Russian Journal of Preventive Medi­cine. 2025;(3):73-79
Substantiation of the anti-inflammatory effect of photodynamic therapy in periodontal diseases. Russian Journal of Stomatology. 2025;(1):40-45
Comparative asse­ssment of the onychomycosis phototherapy methods effi­cacy. Russian Journal of Clinical Dermatology and Vene­reology. 2025;(3):313-318
Photodynamic and microcurrent therapy in reha­bilitation after facial plastic surgery. Plastic Surgery and Aesthetic Medi­cine. 2025;(2-2):65-68
Method of photodynamic action in surgical treatment of local limi­ted peri­tonitis in the expe­riment. Russian Journal of Operative Surgery and Clinical Anatomy. 2025;(2-2):77-86
Abstract:

Corneal neovascularization is one of the most common causes of decreased visual acuity and disability for vision loss, increase in the risk of corneal graft rejection, and appearance of opacifications on the cornea. This article reviews literature on etiological factors of the development of corneal neovascularization, as well as modern methods of diagnosis, conservative and surgical treatment of this pathology.

Keywords:

corneal neovascularization
fine-needle diathermy
anterior segment optical coherence tomography
photodynamic therapy
angiogenesis

Authors:

Malyugin B.E.

S.N. Fedorov National Medical Research Center “MNTK “Eye Microsurgery”;
A.I. Yevdokimov Moscow State University of Medicine and Dentistry

Isabekov R.S.

S.N. Fedorov National Medical Research Center “MNTK “Eye Microsurgery”

Kalinnikova S.Yu.

The S.N. Fedorov National Medical Research Center “MNTK “Eye Microsurgery”

Antonova O.P.

S.N. Fedorov National Medical Research Center “MNTK “Eye Microsurgery”

Received:

05.05.2022

Accepted:

22.06.2022

Close metadata

References:

  1. Beebe D. Maintaining transparency: A review of the developmental physiology and pathophysiology of two avascular tissues. Semin Cell Dev Biol. 2008;19(2):125-133.  https://doi.org/10.12669/pjms.292.3089
  2. Lee P, Wang C, Adamis A. Ocular Neovascularization. Surv Ophthalmol. 1998;43(3):245-269.  https://doi.org/10.1016/s0039-6257(98)00035-6
  3. Bhatti N, Qidwai U, Hussain M, Kazi A. Efficacy of topical Bevacizumab in high-risk corneal transplant survival. Pak J Med Sci. 2013;29(2):519-522.  https://doi.org/10.12669/pjms.292.3089
  4. Pedram Hamrah Y. Corneal Allograft Rejection: Immunopathogenesis to Therapeutics. J Clin Cell Immunol. 2013;2013(suppl 9):006.  https://doi.org/10.4172/2155-9899.S9-006
  5. Qazi Y, Maddula S, Ambati B. Mediators of ocular angiogenesis. J Genet. 2009;88(4):495-515.  https://doi.org/10.1007/s12041-009-0068-0
  6. Chauhan SK, Dohlman TH, Dana R. Corneal Lymphatics: Role in Ocular Inflammation as Inducer and Responder of Adaptive Immunity. J Clin Cell Immunol. 2014;5:1000256. https://doi.org/10.4172/2155-9899.1000256
  7. Chang JH, Garg NK, Lunde E, Han KY, Jain S, Azar DT. Corneal neovascularization: an anti-VEGF therapy review. Surv Ophthalmol. 2012;57(5): 415-429.  https://doi.org/10.1016/j.survophthal.2012.01.007
  8. Han KY, Chang JH, Lee H, Azar DT. Proangiogenic Interactions of Vascular Endothelial MMP14 with VEGF Receptor 1 in VEGFA-Mediated Corneal Angiogenesis. Invest Ophthalmol Vis Sci. 2016;57(7):3313-3322. https://doi.org/10.1167/iovs.16-19420
  9. Neufeld G, Cohen T, Gengrinovitch S, Poltorak Z. Vascular endothelial growth factor (VEGF) and its receptors. FASEB J. 1999;13(1):9-22.  https://doi.org/10.1096/fasebj.13.1.9
  10. Kirwan RP, Zheng Y, Tey A, Anijeet D, Sueke H, Kaye SB. Quantifying changes in corneal neovascularization using fluorescein and indocyanine green angiography. Am J Ophthalmol. 2012;154(5):850-858.e2.  https://doi.org/10.1016/j.ajo.2012.04.021
  11. Kwiterovich KA, Maguire MG, Murphy RP, et al. Frequency of adverse systemic reactions after fluorescein angiography. Results of a prospective study. Ophthalmology. 1991;98(7):1139-1142. https://doi.org/10.1016/s0161-6420(91)32165-1
  12. Stanga PE, Lim JI, Hamilton P. Indocyanine green angiography in chorioretinal diseases: indications and interpretation: an evidence-based update. Ophthalmology. 2003;110(1):15-23.  https://doi.org/10.1016/s0161-6420(02)01563-4
  13. Ang M, Cai Y, Shahipasand S, et al. En face optical coherence tomography angiography for corneal neovascularisation. Br J Ophthalmol. 2016;100(5): 616-621.  https://doi.org/10.1136/bjophthalmol-2015-307338
  14. Ang M, Sim DA, Keane PA, et al. Optical Coherence Tomography Angiography for Anterior Segment Vasculature Imaging. Ophthalmology. 2015; 122(9):1740-1747. https://doi.org/10.1016/j.ophtha.2015.05.017
  15. Varma S, Shanbhag SS, Donthineni PR, Mishra DK, Singh V, Basu S. High-Resolution Optical Coherence Tomography Angiography Characteristics of Limbal Stem Cell Deficiency. Diagnostics (Basel). 2021;11(6):1130. Published 2021 Jun 21.  https://doi.org/10.3390/diagnostics11061130
  16. Brunner M, Romano V, Steger B, et al. Imaging of Corneal Neovascularization: Optical Coherence Tomography Angiography and Fluorescence Angiography. Invest Ophthalmol Vis Sci. 2018;59(3):1263-1269. https://doi.org/10.1167/iovs.17-22035
  17. Chan SY, Pan CT, Feng Y. Localization of Corneal Neovascularization Using Optical Coherence Tomography Angiography. Cornea. 2019;38(7):888-895.  https://doi.org/10.1097/ICO.0000000000001931
  18. Gomer CJ, Ferrario A, Hayashi N, Rucker N, Szirth BC, Murphree AL. Molecular, cellular, and tissue responses following photodynamic therapy. Lasers Surg Med. 1988;8(5):450-463.  https://doi.org/10.1002/lsm.1900080503
  19. Belyi YuA, Tereshchenko AV, Kaplan MA, Pupkova TN. Photodynamic therapy for corneal neovascularization with photosensitizer Photolon. Review. Refraktsionnaya khirurgiya i oftal’mologiya. 2009;(1):4-15 (In Russ.).
  20. Filatova NV, Sidorenko EI, Filatov VV, Chinnov IM, Murav’ev MV. The effectiveness of photodynamic therapy with the photosensitizer photodiazine in the treatment of corneal neovascularization in children. Russian Ophthalmology of Children = Rossiyskaya detskaya oftal’mologiya. 2014;(4):46-50. (In Russ.).
  21. Pillai CT, Dua HS, Hossain P. Fine needle diathermy occlusion of corneal vessels. Invest Ophthalmol Vis Sci. 2000;41(8):2148-2153. https://doi.org/10.1136/bjophthalmol-2014-304891
  22. Wertheim MS, Cook SD, Knox-Cartwright NE, Van DL, Tole DM. Electrolysis-needle cauterization of corneal vessels in patients with lipid keratopathy. Cornea. 2007;26(2):230-231.  https://doi.org/10.1097/01.ico.0000248383.09272.ee
  23. Trikha S, Parikh S, Osmond C, Anderson DF, Hossain PN. Long-term outcomes of Fine Needle Diathermy for established corneal neovascularisation. Br J Ophthalmol. 2014;98(4):454-458.  https://doi.org/10.1136/bjophthalmol-2013-303729
  24. Faraj LA, Elalfy MS, Said DG, Dua HS. Fine needle diathermy occlusion of corneal vessels. Br J Ophthalmol. 2014;98(9):1287-1290. https://doi.org/10.1136/bjophthalmol-2014-304891
  25. Cursiefen C, Viaud E, Bock F, et al. Aganirsen antisense oligonucleotide eye drops inhibit keratitis-induced corneal neovascularization and reduce need for transplantation: the I-CAN study. Ophthalmology. 2014;121(9):1683-1692. https://doi.org/10.1016/j.ophtha.2014.03.038
  26. Jovanovic V, Nikolic L. The effect of topical doxycycline on corneal neovascularization. Curr Eye Res. 2014;39(2):142-148.  https://doi.org/10.3109/02713683.2013.833246
  27. Feizi S, Azari AA, Safapour S. Therapeutic approaches for corneal neovascularization. Eye Vis (Lond). 2017;4:28. Published 2017 Dec 10.  https://doi.org/10.1186/s40662-017-0094-6
  28. Zapata G, Racca L, Tau J, Berra A. Topical use of rapamycin in herpetic stromal keratitis. Ocul Immunol Inflamm. 2012;20(5):354-359.  https://doi.org/10.3109/09273948.2012.709575
  29. Cejkova J, Cejka C, Trosan P, Zajicova A, Sykova E, Holan V. Treatment of alkali-injured cornea by cyclosporine A-loaded electrospun nanofibers — An alternative mode of therapy. Exp Eye Res. 2016;147:128-137.  https://doi.org/10.1016/j.exer.2016.04.016
  30. Park JH, Joo CK, Chung SK. Comparative study of tacrolimus and bevacizumab on corneal neovascularization in rabbits. Cornea. 2015;34(4):449-455.  https://doi.org/10.1097/ICO.0000000000000336
  31. Ferrari G, Dastjerdi MH, Okanobo A, et al. Topical ranibizumab as a treatment of corneal neovascularization. Cornea. 2013;32(7):992-997.  https://doi.org/10.1097/ICO.0b013e3182775f8d
  32. Trufanov SV, Malozhen SA, Krakhmaleva DA, Surnina ZV, Pivin EA, Kasparova E.A. Antiangiogenic therapy in high-risk keratoplasty. Russian Annals of Ophthalmology = Vestnik oftal’mologii. 2020;136(4):11-18 (In Russ.). https://doi.org/10.17116/oftalma202013604111
  33. Ucgul RK, Celebi S, Yilmaz NS, Bukan N, Ucgul AY. Intrastromal versus subconjunctival anti-VEGF agents for treatment of corneal neovascularization: a rabbit study. Eye (Lond). 2021;35(11):3123-3130. https://doi.org/10.1038/s41433-020-01347-3
  34. Onder HI, Erdurmus M, Bucak YY, Simavli H, Oktay M, Kukner AS. Inhibitory effects of regorafenib, a multiple tyrosine kinase inhibitor, on corneal neovascularization. Int J Ophthalmol. 2014;7(2):220-225. Published 2014 Apr 18.  https://doi.org/10.3980/j.issn.2222-3959.2014.02.06
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.