Effect of conventional and orthokeratological hard contact lenses on anatomical and functional characteristics of the cornea

Avetisov S.E.; Musaeva G.M.; Bubnova I.A.

doi:https://doi.org/10.17116/oftalma20231390117

Avetisov S.E.

Krasnov Research Institute of Eye Disease;
I.M. Sechenov First Moscow State Medical University (Sechenov University)

ORCID: 0000-0001-7115-4275

Musaeva G.M.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Bubnova I.A.

Research Institute of Eye Diseases

Effect of conventional and orthokeratological hard contact lenses on anatomical and functional characteristics of the cornea

Authors:

Avetisov S.E., Musaeva G.M., Bubnova I.A.

More about the authors

Journal: Russian Annals of Ophthalmology. 2023;139(1): 7‑15

DOI: 10.17116/oftalma20231390117

Read: 3957 times

To cite this article:

Avetisov SE, Musaeva GM, Bubnova IA. Effect of conventional and orthokeratological hard contact lenses on anatomical and functional characteristics of the cornea. Russian Annals of Ophthalmology. 2023;139(1):7‑15. (In Russ., In Engl.)
https://doi.org/10.17116/oftalma20231390117

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)

Использование инфографики авторами научных работ

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PURPOSE

This study evaluated the potential effects of conventional hard contact lenses (HCL) and orthokeratological contact lenses (OKL) on anatomical and functional condition of the cornea in myopia correction.

MATERIAL AND METHODS

The study included 80 patients (159 eyes) with low, moderate and high myopia. Group 1 consisted of 40 patients (79 eyes) who used conventional HCL; group 2 included 40 patients (80 eyes) who used OKL. All patients underwent topographic keratometry, corneal pachymetry mapping (Pentacam, Oculus, Germany; Visante OCT, Carl Zeiss, Germany), high-order aberrometry (OPD Scan, Nidek, Japan), confocal microscopy (Confoscan 4, Nidek, Japan), evaluation of corneal biomechanical properties (ORA, Reichert Technologies, USA) and corneal light scattering (Pentacam, Oculus, Germany). Examinations were taken before the treatment started and after 8—12 months of contact lens wear.

RESULTS

Group 1 showed corneal thickness increase in all zones (by 0.9—1.1%), no significant changes in corneal refraction, and increase in corneal hysteresis and corneal resistance factor. OKL wear led to a significant flattening of anterior surface of the cornea and steepening of its paracentral area, decrease in central corneal thickness (by 2.8%) and increase in mid-peripheral thickness (by 2.2%). No significant changes in posterior corneal surface were observed in the study patients. More significant increase in higher-order aberrations and the degree of light scattering was observed in group 2, while changes in subepithelial nerve plexus and stromal structure were more significant in group 1.

CONCLUSION

Long-term OKL wear shows more significant morphological and functional corneal changes compared to RGP lens.

Keywords:

cornea

myopia

rigid gas permeable lenses

orthokeratology contact lenses

Authors:

Avetisov S.E.

Krasnov Research Institute of Eye Disease;
I.M. Sechenov First Moscow State Medical University (Sechenov University)

ORCID: 0000-0001-7115-4275

Musaeva G.M.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Bubnova I.A.

Research Institute of Eye Diseases

Received:

14.02.2022

Accepted:

25.02.2022

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References:

Hu X, Shi G, Liu H, Jiang X, Deng J, Zhu C, Yuan Y, Ke B. Microbial Contamination of Rigid Gas Permeable (RGP) Trial Lenses and Lens Cases in China. Curr Eye Res. 2020;45(5):550-555. https://doi.org/10.1080/02713683.2019.1687726
Lee G-H, Yu H-S, Lee J-E. Effects of multipurpose solutions on the adhesion of Acanthamoeba to rigid gas permeable contact lenses. Ophthalm Physiol Optics. 2016;36(2):93-99. https://doi.org/10.1111/opo.12277
Mountford JA, Ruston D, Dave T. Orthokeratology: principles and practice. Butterworth-Heinemann. 2004.
Swarbrick HA. Orthokeratology (corneal refractive therapy): what is it and how does it work? Eye Contact Lens. 2004;30(4):181-185; discussion 205-206. https://doi.org/10.1097/01.icl.0000140221.41806.6e
Tarutta EP, Verzhanskaia TYu, Vahova ES, Asitinskaya PV, Shmakova AG, Shmakov AN, Mitsayafov DS, Popova LA, Hurai AR, Epishina MV, Milash SV. Ortokeratologiya: osnovy podbora OK-linz i vedeniya patsiyentov v spetsializirovannykh oftal’mologicheskikh klinikakh. Metodicheskoye posobiye [Orthokeratology: basics of OK lenses selection and patient management in specialized ophthalmological clinics. Methodical manual]. M. 2016. (In Russ.).
Lee Y-C, Wang J-H, Chiu C-J. Effect of Orthokeratology on Myopia Progression: Twelve-Year Results of a Retrospective Cohort Study. BMC Ophthalmol. 2017;17(1):243. https://doi.org/10.1186/s12886-017-0639-4
Ren Q, Yang B, Liu P. Orthokeratology in adults and factors affecting success: Study design and preliminary results. Contact Lens Anterior Eye. 2020; 43(6):595-601. https://doi.org/10.1016/j.clae.2020.03.016
Swarbrick H, Alharbi A, Watt E, Lum E, Kang P. Myopia Control During Orthokeratology Lens Wear in Children Using a Novel Study Design. Ophthalmology. 2015;122(3):620-630. https://doi.org/10.1016/j.ophtha.2014.09.028
Avetisov SE, Borodina NV, Kobzova MV, Musayeva GM. Current approaches to evaluating the anatomic and functional status of the cornea. Russian Annals of Ophthalmology = Vestnik oftal’mologii. 2010;126(4):59-63. (In Russ.). https://elibrary.ru/item.asp?id=15183854
Liu YM, Xie P. The Safety of Orthokeratology — A Systematic Review. Eye Contact Lens. 2016;42(1):35-42. https://doi.org/10.1097/ICL.0000000000000219
Gardner HP, Fink BA, Mitchell LG, Hill RM. The Effects of High-Dk Rigid Contact Lens Center Thickness, Material Permeability, and Blinking on the Oxygen Uptake of the Human Cornea. Optometry Vis Sci. 2005;82(6):459-466. https://doi.org/10.1097/01.opx.0000168562.64251.66
Yeniad B, Yiğit B, İşsever H, Bilgin LK. Effects of Contact Lenses on Corneal Thickness and Corneal Curvature During Usage. Eye Contact Lens. 2003;29(4):223-229. https://doi.org/10.1097/01.icl.0000086494.50288.70
Vincent SJ, Alonso-Caneiro D, Collins MJ. The time course and nature of corneal oedema during sealed miniscleral contact lens wear. Contact Lens Anterior Eye. 2019;42(1):49-54. https://doi.org/10.1016/j.clae.2018.03.001
Fink BA, Mitchell LG, Hill RM. Rigid Gas-Permeable Contact Lens Base Curve Radius and Transmissibility Effects on Corneal Oxygen Uptake. Optometry Vis Sci. 2006;83(10):740-744. https://doi.org/10.1097/01.opx.0000232806.06677.97
Graham AD, Fusaro RE, Polse KA, Lin MC, Giasson CJ. Predicting extended wear complications from overnight corneal swelling. Invest Ophthalmol Vis Sci. 2001;42(13):3150-3157.
Efron N, Mutalib HA, Perez-Gonez I, Koh HH. Confocal microscopic observations of the human cornea following overnight contact lens wear. Clin Exper Optometry. 2002;85(3):149-155. https://doi.org/10.1111/j.1444-0938.2002.tb03027.x
Verzhanskaya TYu, Tarutta EP, Manukjan IV, Toloraja RR. The impact of orthokeratologic contact lenses on the eye anterior chamber structures. Russian Ophthalmological Journal = Rossiyskiy oftal’mologicheskiy zhurnal. 2009; (2):30-34. (In Russ.). https://elibrary.ru/download/elibrary_19121487_31895425.pdf
Nagorsky PG, Belkina VV, Glok MA, Chernykh VV. The state of epithelium and corneal stroma in children with myopia using orthokeratology lenses (according to data from optical coherence tomography). Sovremennaya optometriya. 2012;(2):18-27. (In Russ.). https://elibrary.ru/item.asp?id=17702927
Zhang J, Li J, Li X, Li F, Wang T. Redistribution of the corneal epithelium after overnight wear of orthokeratology contact lenses for myopia reduction. Contact Lens Anterior Eye. 2020;43(3):232-237. https://doi.org/10.1016/j.clae.2020.02.015
Bullimore MA, Johnson LA. Overnight orthokeratology. Contact Lens Anterior Eye. 2020;43(4):322-332. https://doi.org/10.1016/j.clae.2020.03.018
Kim WK, Kim BJ, Ryu IH, Kim JK, Kim SW. Corneal epithelial and stromal thickness changes in myopic orthokeratology and their relationship with refractive change. PLOS One. 2018;13(9):e0203652. https://doi.org/10.1371/journal.pone.0203652
Yoon JH, Swarbrick HA. Posterior corneal shape changes in myopic overnight orthokeratology. Optometry Vis Sci. 2013;90(3):196-204. https://doi.org/10.1097/OPX.0b013e31828121eb
Krasnov MM, Mamikonyan VR. Keratoepitheliomilesis — a new type of surgical treatment for myopia. Russian Annals of Ophthalmology = Vestnik oftal’mologii. 1990;(3):14-18. (In Russ.).
Tarutta EP, Aliaeva OO, Verzhanskaia TYu, Milash SV. Results of corneal and total astigmatism estimation by different methods in myopic patients wearing orthokeratology contact lenses. Russian Annals of Ophthalmology = Vestnik oftal’mologii. 2013;129(4):59-65. (In Russ.). https://elibrary.ru/item.asp?id=20264984
Chang C-F, Cheng H-C. Effect of Orthokeratology Lens on Contrast Sensitivity Function and High-Order Aberrations in Children and Adults. Eye Contact Lens. 2020;46(6):375-380. https://doi.org/10.1097/ICL.0000000000000667
Lau JK, Vincent SJ, Cheung S-W, Cho P. The influence of orthokeratology compression factor on ocular higher-order aberrations. Clin Exper Optometry. 2020;103(1):123-128. https://doi.org/10.1111/cxo.12933
Mao XJ, Huang CC, Chen L, Lü F. [A study on the effect of the corneal biomechanical properties undergoing overnight orthokeratology]. Chinese J Ophthalmol = Zhonghua Yan Ke Za Zhi. 2010;46(3):209-213. (In Chinese).
Tarutta EP, Verzhanskaya TYu, Toloraya RR, Manukyan IV. The influence of orthokeratologic (ok) lens wear on the corneal status: confocal microscopy scanning data. Russian Ophthalmological Journal = Rossiyskiy oftal’mologicheskiy zhurnal. 2010;(3):37-42. (In Russ.). https://elibrary.ru/item.asp?id=19121575
Nieto-Bona A, González-Mesa A, Nieto-Bona MP, et al. Long-term changes in corneal morphology induced by overnight orthokeratology. Curr Eye Res. 2011;36(10):895-904. https://doi.org/10.3109/02713683.2011.593723