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Drakon A.K.

Research Institute of Eye Diseases

Kurguzova A.G.

Krasnov Research Institute of Eye Diseases

Sheludchenko V.M.

Krasnov Research Institute of Eye Diseases

Korchazhkina N.B.

Russian research center of surgery named after academician B.V. Petrovsky;
The Moscow state medical University named after A.I. Evdokimov of the Ministry of health of Russia

Pharmacological and physiotherapeutic methods of treating non-exudative age-related macular degeneration

Authors:

Drakon A.K., Kurguzova A.G., Sheludchenko V.M., Korchazhkina N.B.

More about the authors

Journal: Russian Annals of Ophthalmology. 2021;137(5‑2): 262‑267

DOI: 10.17116/oftalma2021137052262

Read: 2434 times

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PHARMACOLOGICAL AND PHYSIOTHERAPEUTIC METHODS OF TREATING NON-EXUDATIVE AGE-RELATED MACULAR DEGENERATION
PHARMACOLOGICAL AND PHYSIOTHERAPEUTIC METHODS OF TREATING NON-EXUDATIVE AGE-RELATED MACULAR DEGENERATION

To cite this article:

Drakon AK, Kurguzova AG, Sheludchenko VM, Korchazhkina NB. Pharmacological and physiotherapeutic methods of treating non-exudative age-related macular degeneration. Russian Annals of Ophthalmology. 2021;137(5‑2):262‑267. (In Russ.)
https://doi.org/10.17116/oftalma2021137052262

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The non-exudative form of age-related macular degeneration (AMD) is a disease with long-term progression for which effective treatments have not been found. Many studies are being conducted to find effective drugs to prevent the appearance of drusen and increase in RPE atrophy area, which could help avoid this more dangerous form of AMD. The main drugs (nutraceuticals) that are used to treat the dry form of AMD are lutein, zeaxanthin and omega-3 fatty acids. Additionally, treatment may include nanosecond laser therapy for drusen in advanced AMD, panretinal subthreshold micropulse laser exposure for atrophic AMD, as well as microcurrent stimulation. Further research in this area should be aimed at understanding all the pathogenetic mechanisms associated with the development of AMD, and developing new approaches to the treatment of this disease including physiotherapy.

Keywords:

age-related macular degeneration
drusen
lipofuscin
oxidative stress
lutein
zeaxanthin
laser treatment
physiotherapy

Authors:

Drakon A.K.

Research Institute of Eye Diseases

Kurguzova A.G.

Krasnov Research Institute of Eye Diseases

Sheludchenko V.M.

Krasnov Research Institute of Eye Diseases

Korchazhkina N.B.

Russian research center of surgery named after academician B.V. Petrovsky;
The Moscow state medical University named after A.I. Evdokimov of the Ministry of health of Russia

Received:

24.03.2021

Accepted:

09.05.2021

Close metadata

References:

  1. Congdon N, O’Colmain B, Klaver CC, Klein R, Muñoz B, Friedman DS, Kempen J, Taylor HR, Mitchell P; Eye Diseases Prevalence Research Group. Causes and prevalence of visual impairment among adults in the United States. Archives of Ophthalmology. 2004;122(4):477-485.  https://doi.org/10.1001/archopht.122.4.477
  2. Lim LS, Mitchell P, Seddon JM, Holz FG, Wong TY. Age-related macular degeneration. Lancet. 2012;379(9827):1728-1738. https://doi.org/10.1016/s0140-6736(12)60282-7
  3. Stahl A. The diagnosis and treatment of age-related macular degeneration. Deutsches Arzteblatt International. 2020;117(29-30):513-520.  https://doi.org/10.3238/arztebl.2020.0513
  4. Klein R, Klein BE, Lee KE, Cruickshanks KJ, Gangnon RE. Changes in visual acuity in a population over a 15-year period: The Beaver Dam Eye Study. American Journal of Ophthalmology. 2006;142(4):539-549.  https://doi.org/10.1016/j.ajo.2006.06.015
  5. Klein R, Klein BE, Jensen SC, Meuer SM. The five-year incidence and progression of age-related maculopathy. The Beaver Dam Eye Study. Ophthalmology. 1997;104(1):7-21.  https://doi.org/10.1016/s0161-6420(97)30368-6
  6. Efendieva MKh, Rudko AS, Karpilova MA. Pathophysiological aspects of age-related macular degeneration and glaucoma. Natsional’nyj zhurnal glaukoma. 2016;15(3):81-92. (In Russ.).
  7. Shelankova AV, Budzinskaya MV, Andreeva IV, Afanasyeva MA. Real clinical practice of antiangiogenic therapy in patients with age-related macular degeneration. Retrospective analysis of functional results. Vestnik oftal’mologii. 2020;136(4):207-213. (In Russ.). https://doi.org/10.17116/oftalma2020136042207
  8. Gehrs KM, Jackson JR, Brown EN, Allikmets R, Hageman GS. Complement, age-related macular degeneration and a vision of the future. Archives of Ophthalmology. 2010;128(3):349-358.  https://doi.org/10.1001/archophthalmol.2010.18
  9. Klein R, Klein BE, Tomany SC, Moss SE. Ten-year incidence of age-related maculopathy and smoking and drinking: the Beaver Dam Eye Study. American Journal of Epidemiology. 2002;156(7):589-598.  https://doi.org/10.1093/aje/kwf092
  10. Mares-Perlman JA, Brady WE, Klein R, Van den Langenberg GM, Klein BE, Palta M. Dietary fat and age-related maculopathy. Archives of Ophthalmology. 1995;113(6):743-748.  https://doi.org/10.1001/archopht.1995.01100060069034
  11. Klein R, Klein BE, Tomany SC, Cruickshanks KJ. The association of cardiovascular disease with the long-term incidence of age-related maculopathy: The Beaver Dam Eye Study. Ophthalmology. 2003;110(6):1273-1280. https://doi.org/10.1016/s0161-6420(02)01448-3
  12. Warburton S, Southwick K, Hardman RM, Secrest AM, Grow RK, Xin H, Woolley AT, Burton GF, Thulin CD. Examining the proteins of functional retinal lipofuscin using analysis as a guide for understanding its origin. Molecular Vision. 2005;11:1122-1134. https://doi.org/10.1016/j.exer.2005.01.007
  13. Sheremet NL, Andreeva NA, Zhorzholadze NV, Shmelkova MS, Fomin AV. Structural and functional changes in the retina and optic nerve in patients with toxic optic neuropathy caused by acute methanol poisoning. Vestnik oftal’mologii. 2020;136(4):243-250. (In Russ.). https://doi.org/10.17116/oftalma2020136042243
  14. Budzinskaya MV, Durzhinskaya MKh. Differential diagnosis of hydroxychloroquine-induced retinal damage. Vestnik oftal’mologii. 2020;136(4):265-271. (In Russ.). https://doi.org/10.17116/oftalma2020136042265
  15. Strauss O. The retinal pigment epithelium in visual function. Physiological Reviews. 2005;85(3):845-881.  https://doi.org/10.1152/physrev.00021.2004
  16. Sheremet NL, Ronzina IA, Mikaleyan AA, Zhorzholadze NV, Plyukhova AA, Kiselev SL. Morphological and functional indicators of retinal pigment epithelium and photoreceptor apparatus in inherited retinal diseases. Vestnik oftal’mologii. 2020;136(4-2):183-192. (In Russ.). https://doi.org/10.17116/oftalma2020136042183
  17. Sparrow JR, Boulton M. RPE lipofuscin and its role in retinal pathobiology. Experimental Eye Research. 2005;80(5):595-606.  https://doi.org/10.1016/j.exer.2005.01.007
  18. Nowak JZ. Age-related macular degeneration (AMD): pathogenesis and therapy. Pharmacological Reports: PR. 2006;58(3):353-363.  https://doi.org/10.1037/e606252007-001
  19. Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report No. 8. Archives of Ophthalmology. 2001;119(10): 1417-1436. https://doi.org/10.1001/archopht.119.10.1417
  20. Age-Related Eye Disease Study 2 Research Group. Lutein+zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial. JAMA. 2013; 309(19):2005-2015. https://doi.org/10.3410/f.718007638.793478653
  21. Fayzrakhmanov RR, Budzinskaya MV. Macular pigments in retinal degenerative processes. Vestnik oftal’mologii. 2018;134(5):135-140. (In Russ.). https://doi.org/10.17116/oftalma2018134051135
  22. Gamidov AA, Baryshev KV, Perevozchikov KA, Surnina ZV. Atomic force microscopy in the study of retinal structure. Vestnik oftal’mologii. 2020;136(4): 251-257. (In Russ.). https://doi.org/10.17116/oftalma2020136042251
  23. Khan KN, Mahroo OA, Khan RS, Mohamed MD, McKibbin M, Bird A. Differentiating drusen: Drusen and drusen-like appearances associated with ageing, age-related macular degeneration, inherited eye disease and other pathological processes. Progress in Retinal and Eye Research. 2016;53: 70-106.  https://doi.org/10.1016/j.preteyeres.2016.04.008
  24. Afanasyeva MA, Budzinskaya MV, Plyukhova AA. Current understanding of pachychoroid spectrum diseases. Vestnik oftal’mologii. 2019;135(5):293-298. (In Russ.). https://doi.org/10.17116/oftalma2019135052293
  25. Kiseleva TN, Lagutina YuM, Kravchuk EA. Modern aspects of pathogenesis, clinic and treatment of non exudative forms of age-related macular degeneration. RMZh. Klinicheskaya oftal’mologiya. 2006;3:99. (In Russ.).
  26. Sacconi R, Corbelli E, Querques L, Bandello F, Querques G. A Review of Current and Future Management of Geographic Atrophy. Ophthalmology and Therapy. 2017;6(1):69-77.  https://doi.org/10.1007/s40123-017-0086-6
  27. Velilla S, García-Medina JJ, García-Layana A, Dolz-Marco R, Pons-Vázquez S, Pinazo-Durán MD, Gómez-Ulla F, Arévalo JF, Díaz-Llopis M, Gallego-Pinazo R. Smoking and age-related macular degeneration: review and update. Journal of Ophthalmology. 2013;2013:895147. https://doi.org/10.1155/2013/895147
  28. Lee S, Song SJ, Yu HG. Current smoking is associated with a poor visual acuity improvement after intravitreal ranibizumab therapy in patients with exudative agerelated macular degeneration. Journal of Korean Medical Science. 2013;28(5):769-774.  https://doi.org/10.3346/jkms.2013.28.5.769
  29. Handa JT, Bowes Rickman C, Dick AD, Gorin MB, Miller JW, Toth CA, Ueffing M, Zarbin M, Farrer LA. A systems biology approach towards understanding and treating non-neovascular age-related macular degeneration. Nature Communications. 2019;10(1):3347. https://doi.org/10.1038/s41467-019-11262-1
  30. Guymer RH, Wu Z, Hodgson LAB, Caruso E, Brassington KH, Tindill N, Aung KZ, McGuinness MB, Fletcher EL, Chen FK, Chakravarthy U, Arnold JJ, Heriot WJ, Durkin SR, Lek JJ, Harper CA, Wickremasinghe SS, Sandhu SS, Baglin EK, Sharangan P, Braat S, Luu CD; Laser Intervention in Early Stages of Age-Related Macular Degeneration Study Group. Subthreshold nanosecond laser intervention in age-related macular degeneration: The LEAD randomized controlled clinical trial. Ophthalmology. 2019; 126(6):829-838.  https://doi.org/10.1016/j.ophtha.2019.07.016
  31. Luttrull JK, Sinclair SH, Elmann S, Chang DB, Kent D. Slowed Progression of Age-Related Geographic Atrophy Following Subthreshold Laser. Clinical Ophthalmology. 2020;14:2983-2993. https://doi.org/10.2147/opth.s268322
  32. Sehic A, Guo S, Cho KS, Corraya RM, Chen DF, Utheim TP. Electrical stimulation as a means for improving vision. The American Journal of Pathology. 2016;186(11):2783-2797. https://doi.org/10.1016/j.ajpath.2016.07.017
  33. Ioileva EE, Filatova EV, Golubeva OV, Gavrilova NA, Gadzhieva NS. Fizioterapevticheskaya reabilitatsiya patsientov s vozrastnoj makulyarnoj degeneratsiej: Uchebnoe posobie dlya klinicheskikh ordinatorov, vrachej-oftal’mologov i vrachei-fizioterapevtov. M.: MGMSU im. A.I. Evdokimova; 2017:19-28. (In Russ.).
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