Primary open-angle glaucoma is a major cause of irreversible blindness in all countries of the world. The pathogenesis of primary open-angle glaucoma has not been resolved. In addition to increased intraocular pressure, pathogenetic factors of this disease such as reduced systemic blood pressure, deterioration of ocular blood flow, as well as vascular dysregulation, reperfusion damage and oxidative stress of ocular tissues are now generally recognized. The role of α1-adrenoreceptors in regulation of, for example, ocular blood flow, blood flow in the retina, permeability of the vascular wall etc has already been described.

PURPOSE

To identify the effects of different subtypes of α1-adrenoreceptors on the level of systemic blood pressure in laboratory mice.

MATERIAL AND METHODS

Features of blood pressure of 36 laboratory mice older than 18 months having a genetic defect (lines ADRA-1A, ADRA-1D and ADRA-1D) of one of the subtypes of α1-adrenoreceptors (α1a, α1b, α1d) were studied. The control group included ten healthy laboratory mice of the same age. The blood pressure of mice was measured with modern high-precision and noninvasive method using the Coda^TM Standard system (Kent Scientific Corporation, U.S.A.).

RESULTS

The mice of the ADRA-1A line were revealed to have reduced systolic and diastolic blood pressure and maximum level of pulse pressure, as well as the greatest fluctuations of pulse pressure; for the ADRA-1B line — the highest levels of systolic and diastolic blood pressure; for the ADRA-1D line — the smallest systolic and diastolic blood pressure and the minimum values of pulse pressure.

CONCLUSION

The obtained results show the specific contribution of α1a, α1b and α1d subtypes of the adrenoreceptors in the maintenance of normal hemodynamic of an organism, which should be considered when studying pathogenesis of primary open-angle glaucoma.