Assessment of changes in the retina of patients with Alzheimer’s disease

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Purpose — to assess the thickness of the retinal nerve fiber layer and its morphometric parameters using optical coherent tomography in Alzheimer’s disease (AD). Material and methods. The study included 105 patients, among which 45 were with AD and 60 patients without AD (control group). Visual acuity of each eye was measured using Snellen chart, intraocular pressure according to Goldman, and cognitive state on the MMSE scale. All patients underwent optical coherence tomography. Results. The average thickness of the nerve fibers of the retina in patients with AD was lower by 27.0%, in the temporal, upper and lower quadrants — by 24.0, 17.9 and 24.9%, respectively. The thickness in the nasal quadrant with AD was reduced by 15.4%. Excavation to diameter ratio, as well as vertical and horizontal excavation to diameter ratios on average exceeded the benchmark by 12.5%, 23.4% and 30.8% (p<0.05), respectively. There was a decrease in the size of the area of the neuroretinal belt and the area of the disk by an average of 28.5% (p<0.05) and 8.8%, respectively. The average thickness, the thickness in the upper and lower segments of the ganglion cell complex is reduced, the indices of focal and global loss of the volume of retinal ganglion cells complex are increased respectively by 1.7 (p<0.05) and 2.8 times (p<0.01). Conclusion. In patients with moderate AD, the thickness of retinal nerve fibers (RNFL) in the temporal, upper, and lower segments decreases significantly (p<0.001); a statistically significant (p<0.05) increase in the excavation to diameter ratio of the optic nerve head and a decrease in the area of the neuroretinal belt is observed; the increase in the indices of focal and global loss of the volume of ganglion cells complex is statistically significant (p<0.01).

Keywords:

Alzheimer’s disease

optical coherence tomography

retina

nerve fibers

ganglion cell complex

optic nerve head

thickness

Authors:

Guliyeva R.N.

National Ophthalmology Center named after Zarifa Aliyeva, Baku, Republic of Azerbaijan

List of references:

Zueva MV. Fundamental ophthalmology: the role of electrophysiological studies. Vestnik oftal’mologii. 2014;6:28-36. (In Russ.).
Emamian F, Khazaie H, Tahmasian M, Leschziner GD, Morrell MJ, Hsiung GY, Rosenzweig I, Sepehry AA. The association between obstructive sleep apnea and Alzheimer’s disease: a meta-analysis perspective. Front Aging Neurosci. 2016;8:78. https://doi.org/10.3389/fnagi.2016.00078
Hickman RA, Faustin A, Wisniewski T. Alzheimer disease and its growing epidemic: risk factors, biomarkers, and the urgent need for therapeutics. Neurol Clin. 2016;34:941-953. https://doi.org/10.1016/j.ncl.2016.06.009
Csincsik L, MacGillivrayc TJ, Flynn E, Pellegrini E, Papanastasiou G, Barzegar-Befroei N, Csutak A, Lengyel I, Bird AC, Ritchie CW, Peto T, Lengyel I. Peripheral Retinal Imaging Biomarkers for Alzheimer’s Disease: A Pilot Study. Ophthalmic Res. 2018;59:182-192. https://doi.org/10.1159/000487053
Cheung CY, Ong YT, Ikram MK, Ong SY, Li X, Hilal S, Catindig JA, Venketasubramanian N, Yap P, Seow D, Chen CP, Wong TY. Microvascular network alterations in the retina of patients with Alzheimer’s disease. Alzheimers Dement. 2014;10:135-142. https://doi.org/10.1016/j.jalz.2013.06.009
Bambo MP, Garcia-Martin E, Gutierrez-Ruiz F, Pinilla J, Perez-Olivan S, Larrosa JM, Polo V, Pablo L. Analysis of optic disk color changes in Alzheimer’s disease: a potential new biomarker. Clin Neurol Neurosurg. 2015;132:68-73. https://doi.org/10.1016/j.clineuro.2015.02.016
Coppola G, Di Renzo A, Ziccardi L, Martelli F, Fadda A, Manni G, Barboni P, Pierelli F, Sadun AA, Parisi V. Optical coherence tomography in Alzheimer’s disease: a meta-analysis. PLoS One. 2015;10:e0134750. https://doi.org/10.1371/journal.pone.0134750
La Morgia C, Ross-Cisneros FN, Koronyo Y, Hannibal J, Gallassi R, Cantalupo G, Sambati L, Pan BX, Tozer KR, Barboni P, Provini F, Avanzini P, Carbonelli M, Pelosi A, Chui H, Liquori R, Baruzzi A, Koronyo M, Sadun AA, Carelli V. Melanopsin retinal ganglion cell loss in Alzheimer disease. Ann Neurol. 2016;79:90-109. https://doi.org/10.1002/ana.24548
Méndez-Gómez JL, Pelletier A, Rougier M-B, Korobelnik J-F, Schweitzer C, Delyfer M-N, Catheline G, Monfermé S, Dartigues J-F, Delcourt C, Helmer C. Association of Retinal Nerve Fiber Layer Thickness With Brain Alterations in the Visual and Limbic Networks in Elderly Adults Without Dementia. JAMA Network Open. 2018;1(7):e184406. https://doi.org/10.1001/jamanetworkopen.2018.4406
The World Medical Association (WMA) Declaration of Helsinki Ethical Principles for Medical Research Involving Human Subjects Adopted by the General Assembly, Seoul, Korea, October. 2008.
Akopyan VS, Gavrilova SI, Semenova NS, Fedorova YaB, Gurova EV. Neurodegenerative changes of the retina in Alzheimer’s disease, mild cognitive decline syndrome and glaucoma. Psikhiatriya. 2016;72(4):33-40. (In Russ.).
Tiganov AS, Akopyan VS, Gavrilova SI, Semenova NS, Fedorova YaB, Gurova EV. Neuroarchitecture of the retina of patients with Alzheimer’s disease and mild cognitive decline syndrome (preliminary results). Oftal’mologiya. 2012;9(4):43-46. (In Russ.).
Sperling RA, Aisen PS, Beckett LA, Bennett DA, Craft S, Fagan AM, Iwatsubo T, Jack CRJr, Kaye J, Montine ThJ, Park DC, Reiman EM, Rowe ChC, Siemers E, Stern Y, Yaffe K, Carrillo MC, Thies B, Morrison-Bogorad M, Wagster MV, Phelps CH. Toward defining the preclinical stages of Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement. 2011;7(3):280-292. https://doi.org/10.1016/j.jalz.2011.03.003
Coppola G, Di Renzo A, Ziccardi L, Martelli F, Fadda A, Manni G, Barboni P, Pierelli F, Sadun AA, Parisi V. Optical coherence tomography in Alzheimer’s disease: a meta-analysis. PLoS One. 2015;10(8):e0134750. https://doi.org/10.1371/journal.pone.0134750
Thomson KL, Yeo JM, Waddell B, Cameron JR, Pal S. A systematic review and meta-analysis of retinal nerve fiber layer change in dementia, using optical coherence tomography. Alzheimers Dement. 2015;1(2):136-143. https://doi.org/10.1016/j.dadm.2015.03.001
Erichev VP, Panyushkina LA, Fomin AV. Optical coherence tomography of the retina and optic nerve in the diagnosis of Alzheimer’s disease. Glaukoma. 2013;1:5-10. (In Russ.).
Kurna SA, Akar G, Altun A, Agirman Y, Gozke E, Sengor T. Confocal scanning laser tomography of the optic nerve head on the patients with Alzheimer’s disease compared to glaucoma and control. Int Ophthalmol. 2017;34(6): 1203-1211. https://doi.org/10.1007/s10792-014-0004-z
Danesh-Meyer H, Birch H, Ku J-F, Carroll S, Gamble G. Reduction of optic nerve fibers in patients with Alzheimer disease identified by laser imaging. Neurology. 2006;67(10):1852-1854. https://doi.org/10.1212/01.wnl.0000244490.07925.8b

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