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Dorofeev D.A.

Chair of Surgical diseases №2, Medical Institute of Tula State University, Tula, Russia

Kryzhanovskaya A.V.

South Ural State Medical University, Chelyabinsk, Russia

Ciganov A.Z.

South Ural State Medical University, 64 Vorovskogo St., Chelyabinsk, Russian Federation, 454092

Effectiveness of antihypertensive conservative-free therapy with fixed combination of bimatoprost and timolol (intermediate results)

Authors:

Dorofeev D.A., Kryzhanovskaya A.V., Ciganov A.Z.

More about the authors

Journal: Russian Annals of Ophthalmology. 2020;136(2): 73‑80

DOI: 10.17116/oftalma202013602173

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EFFECTIVENESS OF ANTIHYPERTENSIVE CONSERVATIVE-FREE THERAPY WITH FIXED COMBINATION OF BIMATOPROST AND TIMOLOL (INTERMEDIATE RESULTS)
EFFECTIVENESS OF ANTIHYPERTENSIVE CONSERVATIVE-FREE THERAPY WITH FIXED COMBINATION OF BIMATOPROST AND TIMOLOL (INTERMEDIATE RESULTS)

To cite this article:

Dorofeev DA, Kryzhanovskaya AV, Ciganov AZ. Effectiveness of antihypertensive conservative-free therapy with fixed combination of bimatoprost and timolol (intermediate results). Russian Annals of Ophthalmology. 2020;136(2):73‑80. (In Russ.)
https://doi.org/10.17116/oftalma202013602173

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Introduction. The effects of antihypertensive therapy are often determined by patient compliance with the prescribed treatment plan. Acceptance of conservative-free forms of drugs leads to a decrease in the frequency and severity of side effects, reduces the need for the use of artificial tears, which lowers the cost of treatment for the patients. Purpose — to evaluate the hypotensive effectiveness of a fixed combination of bimatoprost (0.03%) and timolol (0.5%), and its effect on the ocular surface in patients with newly diagnosed advanced glaucoma. Material and methods. The study was conducted during February—November 2018, and included 46 patients (76 eyes) with newly diagnosed POAG and healthy volunteers (control group). All patients underwent visometry, ICare rebound tonometry (Tiolat, Finland), elastometry with Maklakov tonometer (using 5 g, 10 g and 15 g loads), automated perimetry (AP) (Octopus-600, Haag-Streit diagnostics, Switzerland), optical coherence tomography (OCT) of the macular zone and optic nerve head, pachymetry (Spectralis OCT, Heidelberg Engineering, Germany). At the start of the study and one month after the start of treatment with the drug Ganfort (Allergan, USA), patients were examined to evaluate the state of their ocular surface: Norn’s test, Schirmer’s test, vital staining with lissamine green, and an OSDI questionnaire. Results. At the start of treatment, administration of a fixed combination of bimatoprost and timolol led to a decrease in intraocular pressure by 7.9 (37.7%) mm Hg (V=271, p=5.496e—05) after 2 weeks of the use of Ganfort (Allergan, USA). During this period, the observation group did not exhibit statistically significant changes in the state of the ocular surface, which was comparable to the control group according to the data of the Norn’s test, Schirmer’s test, vital staining with lissamine green and the OSDI questionnaire (p>0.05). Conclusion. The use of a fixed combination of bimatoprost and timolol, while effectively reducing IOP, did not result in statistically significant changes in the ocular surface. Some improvement of both objective and subjective indicators of the state of ocular surface associated with the use of the Ganfort drug was noted in patients of the observation group.

Keywords:

glaucoma
dry eye syndrome
ocular surface
intraocular pressure
antihypertensive therapy

Authors:

Dorofeev D.A.

Chair of Surgical diseases №2, Medical Institute of Tula State University, Tula, Russia

Kryzhanovskaya A.V.

South Ural State Medical University, Chelyabinsk, Russia

Ciganov A.Z.

South Ural State Medical University, 64 Vorovskogo St., Chelyabinsk, Russian Federation, 454092

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References:

  1. Abysheva LD, Avdeev RV, Aleksandrov AS, Bakunina NA i dr. Safety characteristics of the established optimal values of the intraocular pressure upper limit in patients with advanced primary open-angle glaucoma in terms of evidence-based medicine. RMZH. Klinicheskaja oftalmologija. 2015;16(3):111-123. (In Russ.).
  2. Kuroedov AV, Abysheva LD, Avdeev RV, Aleksandrov AS, et al. Cost-effectiveness ratio of local hypotensive treatment of patients with moderate and advanced primary open-angle glaucoma (a multicenter study). Rossijskij oftal’mologicheskij zhurnal. 2015;8(3):10-22. (In Russ.).
  3. Onufriichuk ON, Avdeev RV, Aleksandrov AS, Basinskii AS, et al. Morphofunctional retinal changes in patients with non-neovascular age-related macular degeneration (literal review). RMZH. Klinicheskaja oftalmologija. 2013;14(3):123-130. (In Russ.).
  4. Avdeev RV, Aleksandrov AS, Basinskii AS, Blyum EA, et al. Multicentre study of morphofunctional status of visual analyzer in simultaneous presence in eye glaucoma and age-related macular degeneration with determination of correlations and connections. Oftalmologija Vostochnaja Evropa. 2013;4:15-26. (In Russ.).
  5. Kuroedov AV, Abysheva LD, Aleksandrov AS, Bakunina N.A., et al. Management of primary open-angle glaucoma in practice: variants of medical, laser and surgical treatment. Medikobiologicheskie problemy zhiznedejatelnosti. 2016;15(1):170-185. (In Russ.).
  6. Kuroedov AV, Abysheva LD, Avdeev RV, Aleksandrov AS i dr. Medico-economic multicenter study of local hypotensive therapy efficacy and cost for patients with primary open-angle glaucoma in CIS. Oftalmologija Vostochnaja Evropa. 2015;3(26):35-51. (In Russ.).
  7. Kuroedov AV, Abysheva LD, Avdeev RV, Aleksandrov AS i dr. Intraocular pressure level in various local antihypertensive therapy in primary open-angle glaucoma (multicenter study) Oftalmologija Vostochnaja Evropa. 2016;28(1):27-42. (In Russ.).
  8. Dorofeev DA, Ekgardt VF, Shaimov T.B, et al. Tale about the size of optic nerve head. Vestnik Soveta molodykh uchenykh i spetsialistov Chelyabinskoi oblasti. 2014;(1-2):36-40. (In Russ.).
  9. Ekgardt VF, Dorofeev DA, Shaimov TB, et al. About the optic disc size. Kazanskii meditsinskii zhurnal. 2013;94(6):850-853. (In Russ.).
  10. Ekgardt VF, Dorofeev DA. Prostaglandin analogs efficiency in the treatment of simple and pseudoexfoliative open angle glaucoma. Otrazhenie. 2017;1(1):40-46. (In Russ.).
  11. Ekgardt VF, Dorofeev DA. Effects of prostaglandin analogues initial treatment on simple open-angle glaucoma and pseudoexfoliation glaucoma in advanced stages. Natsional’nyi zhurnal glaukoma. 2017;16(1):28-37. (In Russ.).
  12. Lovpache DN, Dorofeev DA. Pharmacoeconomic expediency of the use of preservative-free therapy in the treatment of primary open-angle glaucoma in patients with the dry eye syndrome (intermediate results). RMZH. Klinicheskaja oftalmologija. 2017;18(4):195-200. (In Russ.).
  13. Abysheva LD, Avdeev RV, Aleksandrov AS, et al. [Influence of local hypotensive glaucoma therapy on the development and progression of dry eye syndrome. RMZH. Klinicheskaja oftalmologija. 2017;17(2):74-82. (In Russ.).
  14. Alexeev VN, Zaharova NS. Main medical and social factors influencing the statistics of refusals of patients of undergoing the medicamental, laser and surgical treatment of POAG. RMZH. Klinicheskaja oftalmologija. 2009;10(3):81-83. (In Russ.).
  15. Egorov EA, Astahov YuS, Erichev VP. Evaluation of efficacy and safety of preservative-free tafluprost 0.0015% eye drops in patients with POAG and ophthalmohypertension. RMZH. Klinicheskaja oftalmologija. 2015;15(1):1-6. (In Russ.).
  16. Erichev VP, Ambarcumyan KG. Features of antihypertensive therapy in patients with glaucoma treated with medications containing no preservatives. Prakticheskaya medicina. 2012;4-1(59):194-196. (In Russ.).
  17. Erichev VP, Ambarcumyan KG. The preservatives and secondary dry eye syndrome at topical long-term open-angle glaucoma therapy. Natsional’nyi zhurnal glaukoma. 2011;(2):59-66. (In Russ.).
  18. Grüb M, Rohrbach J. Zur sozioökonomischen Bedeutung des Glaukoms. Klin. Monbl. Augenheilkd. 2006;223(10):793-795. https://doi.org/10.1055/s-2006-926689
  19. Avetisov SE, Bubnova IA, Antonov AA. Once more about the diagnostic capacities of elastic tonometry. Vestnik oftal’mologii. 2008;124(5):19-22. (In Russ.).
  20. Avetisov SE, Novikov IA, Bubnova IA, Antonov AA, Siplivyi VI. Investigation of the biomechanical properties of the cornea by bidirectional applanation: new approaches to interpreting the results. Vestnik oftal’mologii. 2008;124(5):22-25. (In Russ.).
  21. Avetisov SE, Bubnova IA, Petrov SYu, Antonov AA, Reshchikova VS. Peculiarities of biomechanical properties of the fibrous capsule of the eye in patients with primary open-angle glaucoma. Natsional’nyi zhurnal glaukoma. 2012;(4):7-11. (In Russ.).
  22. Krasnov MM. The new principle of measuring IOP (convex tonometry and convex tonography). Vestnik oftal’mologii. 1981;97(1):53-54. (In Russ.).
  23. Krasnov MM, Basov GV. Some results of convex tonography according to M.M. Krasnov. Vestnik oftal’mologii. 1981;97(1):54-55. (In Russ.).
  24. Kass MA, Heuer DK, Higginbotham EJ, Johnson CA, et al. The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma. Arch Ophthalmol. 2002;120(6):701-713. https://doi.org/10.1001/archopht.120.6.701
  25. Nesterov AP, Alekseev VN, Alekseev IB, Amirov AN, et al. Nacional’noe rukovodstvo po glaukome. Dlya praktikuyushchih vrachej. 3-e izd. M.: GEOTAR-Media; 2015. (In Russ.).
  26. Avdeev RV, Bakunina NA, Basinskij AS, Brezhnev AYu, et al. Management of glaucoma progression. Natsional’nyi zhurnal glaukoma. 2019;18(1):45-58. (In Russ.). https://doi.org/10.25700/NJG.2019.01.07
  27. European Glaucoma Society Terminology and Guidelines for Glaucoma, 4th Edition — Chapter 2: Classification and terminologySupported by the EGS Foundation. Br J Ophthalmol. 2017;101(5):73-127. https://doi.org/10.1136/bjophthalmol-2016-EGSguideline.002
  28. Hasebe Y, Kashiwagi K, Tsumura T, Suzuki Y, Yoshikawa K, Suzumura H, et al. Changes in adherence and associated factors among patients on newly introduced prostaglandin analog and timolol fixed-combination therapy. Patient Prefer Adherence. 2018;12:1567-1577. https://doi.org/10.2147/PPA.S168921
  29. Stewart WC, Stewart JA, Nelson LA. Ocular surface disease in patients with ocular hypertension and glaucoma. Curr Eye Res. 2011;36(5):391-398. https://doi.org/10.3109/02713683.2011.562340
  30. Baudouin C, Labbé A, Liang H, Pauly A, Brignole-Baudouin F. Preservatives in eyedrops: the good, the bad and the ugly. Prog Retin Eye Res. 2010;29(4):312-334. https://doi.org/10.1016/j.preteyeres.2010.03.001
  31. Aptel F, Cucherat M, Denis P. Efficacy and tolerability of prostaglandin-timolol fixed combinations: a meta-analysis of randomized clinical trials. Eur J Ophthalmol. 2019;22(1):5-18. https://doi.org/10.5301/ejo.5000009
  32. Cordeiro MF, Goldberg I, Schiffman R, Bernstein P, Liu C, Bejanian M. Efficacy of a preservative-free fixed combination of bimatoprost and timolol in treatment-naïve versus previously treated patients. Acta Ophthalmol. 2013;91(252):4222. https://doi.org/10.1111/j.1755-3768.2013.4222.x
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