Biomechanical properties of the cornea as predictors of the effectiveness of selective laser trabeculoplasty

Kurysheva N.I.; Lepeshkina L.V.

doi:https://doi.org/10.17116/oftalma202013601117

Kurysheva N.I.

Oftal'mologicheskij tsentr Federal'nogo mediko-biologicheskogo agentstva, ul. Gamalei, 15, Moskva, Rossijskaja Federatsija, 123098

SPIN RSCI: 3531-5880
Scopus AuthorID: 6603842519
ORCID: 0000-0002-2265-6671

Lepeshkina L.V.

Ophthalmological Center of the Federal Medical-Biological Agency of the Russian Federation, A.I. Burnazyan Federal Medical and Biophysical Center of FMBA, 15 Gamalei St., Moscow, Russian Federation, 123098

Biomechanical properties of the cornea as predictors of the effectiveness of selective laser trabeculoplasty

Authors:

Kurysheva N.I., Lepeshkina L.V.

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Journal: Russian Annals of Ophthalmology. 2020;136(1): 17‑24

DOI: 10.17116/oftalma202013601117

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To cite this article:

Kurysheva NI, Lepeshkina LV. Biomechanical properties of the cornea as predictors of the effectiveness of selective laser trabeculoplasty. Russian Annals of Ophthalmology. 2020;136(1):17‑24. (In Russ.)
https://doi.org/10.17116/oftalma202013601117

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)

Использование инфографики авторами научных работ

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Abstract:

Purpose – to study the changes in central corneal thickness (CCT) and corneal hysteresis (CH) after selective laser trabeculoplasty (SLT) in primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG) after laser peripheral iridotomy (LPI) and to determine their effect on the prognosis of the surgery. Material and methods. The prospective study involved 68 eyes with initial PACG after LPI and 74 eyes with initial POAG observed for 6 months. Corneal-compensated IOP (IOPcc), corneal resistance factor (CRF), CH and CCT were studied as the predictors of SLT, which was considered successful when IOPcc decreased by 20% or more from the baseline without additional hypotensive therapy and/or repeated SLT. Results. In both forms of glaucoma, CCT increased within the first hour after SLT: 567±24.08 µm (p=0.001) in POAG, and 572±21.41 µm (p=0.000) – persisting for over a month – in PACG. CCT correlated with laser energy at all stages of the examination both in POAG and PACG patients. The following predictors of SLT failure were determined: CH (p=0.000 in PACG and p=0.001 in POAG), as well as initial IOP (p=0.010 in PACG and p=0.016 in POAG) and CRF (p=0.003 in PACG and p=0.005 in POAG) and CCT (p=0.023 in PACG and p=0.026 in POAG). The value of anterior chamber angle (ACA) was a predictor only for PACG (p=0.011). Conclusion. SLT leads to an increase in CCT, which lasts longer in PACG after LPI than in POAG and correlates with the level of laser energy. Lower CH and initially higher IOP are the common predictors of SLT failure in the long term for both forms of glaucoma. Smaller ACA have a negative prognostic sign in POAG.

Keywords:

selective laser trabeculoplasty

primary angle closure glaucoma

primary open angle glaucoma

laser peripheral iridotomy

corneal hysteresis

central corneal thickness

Authors:

Kurysheva N.I.

Oftal'mologicheskij tsentr Federal'nogo mediko-biologicheskogo agentstva, ul. Gamalei, 15, Moskva, Rossijskaja Federatsija, 123098

SPIN RSCI: 3531-5880
Scopus AuthorID: 6603842519
ORCID: 0000-0002-2265-6671

Lepeshkina L.V.

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References:

Waisbourd M, Katz L.J. Selective laser trabeculoplasty as a first-line therapy: a review. Canadian Journal of Ophthalmology. 2014;49(6):519–522. https://doi.org/10.1016/j.jcjo.2014.10.003
Ho CL, Lai JS, Aquino MV, Rojanapongpun P, Wong HT, Aquino MC, Gerber Y, Belkin M, Barkana Y. Selective laser trabeculoplasty for primary angle closure with persistently elevated intraocular pressure after iridotomy. Journal of Glaucoma. 2009;18(7):563–566. https://doi.org/10.1097/ijg.0b013e318193c2d1
Ali Aljasim L, Owaidhah O, Edward DP. Selective Laser Trabeculoplasty in Primary Angle-closure Glaucoma After Laser Peripheral Iridotomy: A Case-Control Study. Journal of Glaucoma. 2016; (3):253–258. https://doi.org/10.1097/ijg.0000000000000282
Radhakrishnan S, Chen PP, Junk AK, Nouri-Mahdavi K, Chen TC. Laser peripheral iridotomy in primary angle closure: a report by the American Academy of Ophthalmology. Ophthalmology. 2018; 125:1110–1120. https://doi.org/10.1016/j.ophtha.2018.01.015
Raj S, Tigari B, Faisal TT, Gautam N, Kaushik S, Ichhpujani P, Pandav SS, Ram J. Efficacy of selective laser trabeculoplasty in primary angle closure disease. Eye (Lond). 2018; 32(11):1710–1716. https://doi.org/10.1038/s41433-018-0165-5
Lee JW, Liu CC, Chan JC, Wong R, Wong Y, Lai JS. Predictors of success in selective laser trabeculoplasty for primary open angle glaucoma in Chinese. Clinical Ophthalmology. 2014; 8:1787–1791. https://doi.org/10.2147/opth.s69166
Barretto GC, Biteli LG, Moreno PA, Prata TS. Selective Laser Trabeculoplasty: Predictors of Short-Term Surgical Outcomes in Open-Angle Glaucoma Patients. Investigative Ophthalmology and Visual Science. 2011; 52: 2624.
Miki A, Kawashima R, Usui S, Matsushita K, Nishida K. Treatment Outcomes and Prognostic Factors of Selective Laser Trabeculoplasty for Open-angle Glaucoma Receiving Maximal-tolerable Medical Therapy. Journal of Glaucoma. 2016; 25(10):785–789. https://doi.org/10.1097/ijg.0000000000000411
Shah M, Eliassi-Rad B. Predictive Factors of Selective Laser Trabeculoplasty (SLT) Outcome in Open-Angle Glaucoma Patients. Investigative Ophthalmology and Visual Science. 2012; 53:5964. https://doi.org/10.4016/41168.01
Ayala M, Chen E. Predictive factors of success in selective laser trabeculoplasty (SLT) treatment. Clinical Ophthalmology. 2011;5:573–576. https://doi.org/10.2147/opth.s19873
Lee JW, Chan JC, Chang RT, Singh K, Liu CC, Gangwani R, Wong MO, Lai JS. Corneal changes after a single session of selective laser trabeculoplasty for open-angle glaucoma. Eye. 2013;28(1):47–52. https://doi.org/10.1038/eye.2013.231
Yilmaz SG, Palamar M, Yusifov E, Ates H, Egrilmez S, Yagci A. Effects of primary selective laser trabeculoplasty on anterior segment parameters. International Journal of Ophthalmology. 2015;8(5):954–959. https://doi.org/10.3980/j.issn.2222-3959.2015.05.18
Avetisov SE, Bubnova IA, Antonov AA. Issledovanie biomehanicheskih svoystv rogovitsyi u patsientov s normotenzivnoy i pervichnoy otkryitougolnoy glaukomoy. Vestnik oftal’mologii. 2008; 124(5):14–16. (In Russ.).
Hirneiss C., Sekura K., Brandlhuber U., Kampik A., Kernt M. Corneal biomechanics predict the outcome of selective laser trabeculoplasty in medically uncontrolled glaucoma. Graefe’s Arch for Clinical and Experimental Ophthalmology. 2013; 251(10):2383–2388. https://doi.org/10.1007/s00417-013-2416-2
Schweitzer J. A., Ervin M., Berdahl J. P. Assessment of corneal hysteresis measured by the ocular response analyzer as a screening tool in patients with glaucoma. Clin Ophthalmol. 2018; 12:1809–1813. https://doi.org/10.2147/OPTH.S168032
Liang L., Zhang R., He L.Y. Corneal hysteresis and glaucoma. Int Ophthalmol. 2018 Sep 5. https://doi.org/10.1007/s10792-018-1011-2
Spaeth G. L. The normal development of the human anterior chamber angle: a new system of descriptive grading. Transactions of the ophthalmological societies of the United Kingdom. 1971;91:709–739.
Macdonald J. M., Geroski D. H., Edelhauser H. F. Effect of inflammation on the cornealendothelial pump and barrier. Current Eye Research. 1987;6(9):1125–1132. https://doi.org/10.3109/02713688709034885
Leahy KE, Madigan MC, Sarris M, Watson SL, McCluskey P, White AJ. Investigation of corneal endothelial changes post selective laser trabeculoplasty. Clinical and Experimental Ophthalmology. 2018. https://doi.org/10.1111/ceo.13172
Kurysheva N, Shatalova E. Polymegathism, Pleomorphism, and Endothelial Cell Count after Selective Laser Trabeculoplasty. Biology and Medicine. 2016;8:7. https://doi.org/10.4172/0974-8369.1000343
Minkowski JS, Bartels SP, Delori FC, Lee SR, Kenyon KR, Neufeld AH. Corneal Endofhelial Function and Structure Following Cryo-lnjury in the Rabbit. Investigative Ophthalmology and Visual Science. 1984;25(12):1416– 1425.
Sharifipour F, Panahi-bazaz M, Bidar R, Idani A, and Cheraghian B. Age-related variations in corneal biomechanical properties. Journal of Current Ophthalmology. 2016; 28(3): 117–122. https://doi.org/10.1016/j.joco.2016.05.004
Johnson CS, Mian SI, Moroi S, Epstein D, Izatt J, Afshari NA. Role of corneal elasticity in damping of intraocular pressure. Investigative Opthalmology and Visual Science. 2007;48(6):2540–2544. https://doi.org/10.1167/iovs.06-0719
Congdon NG, Broman AT, Bandeen-Roche K, Grover D, Quigley HA. Central corneal thickness and corneal 1 hysteresis associated with glaucoma damage. Am J Ophthalmol. 2006;141(5):868–875. https://doi.org/10.1016/j.ajo.2005.12.007
Luce DA. Determining in vivo biomechanical properties of the cornea with an ocular response 28 analyzer. J Cataract Refract Surg. 2005;31(1):156–162. https://doi.org/10.1016/j.jcrs.2004.10.04
Wells AP, Garway-Heath DF, Poostchi A, Wong T, Chan KC, Sachdev N. Corneal hysteresis but not corneal thickness 20 correlates with optic nerve surface compliance in glaucoma patients. Invest Ophthalmol Vis Sci. 21 2008; 49(8):3262–3268. https://doi.org/10.1167/iovs.07-1556
Khawaja AP, Chan MP, Broadway DC, Garway-Heath DF, Luben R, Yip J L, Hayat S, Khaw KT, Foster PJ. Corneal biomechanical properties and glaucoma-33 related quantitative traits in the EPIC-Norfolk Eye Study. Invest Ophthalmol Vis Sci. 2014; 55(1):117–124. https://doi.org/10.1167/iovs.13-13290
Kurysheva NI, Parshunina OA, Shatalova EO, Kiseleva TN, Lagutin MB, Fomin AV. Value of Structural and Hemodynamic Parameters for the Early Detection of Primary Open-Angle Glaucoma. Current Eye Research. 2017; 42(3):411–417. https://doi.org/10.1080/02713683.2016.1184281
Medeiros FA, Meira-Freitas D, Lisboa R, Kuang TM, Zangwill LM, Weinreb RN. Corneal hysteresis as a risk factor for glaucoma progression: a prospective longitudinal study. Ophthalmology. 2013; 120:1533–1540. https://doi.org/10.1016/j.ophtha.2013.01.032
Narayanaswamy A, Su DH, Baskaran M, Tan AC, Nongpiur ME, Htoon H M, Wong TY, Aung T. Comparison of ocular response analyzer parameters in chinese subjects with primary angle-closure and primary open-angle glaucoma. Archives of Ophthalmology. 2011; 129(4):429–434. https://doi.org/10.1001/archophthalmol.2011.60
Klingenstein A, Kernt M, Seidensticker F, Kampik A, Hirneiss C. Anterior-segment morphology and corneal biomechanical characteristics in pigmentary glaucoma. Clinical Ophthalmology. 2014; 8: 119–126. https://doi.org/10.2147/opth.s53088
Yamamoto Y, Uno T, Joko T, Shiraishi A, Ohashi Y. Effect of Anterior Chamber Depth on Shear Stress Exerted on Corneal Endothelial Cells by Altered Aqueous Flow after Laser Iridotomy. Investigative Ophthalmology and Visual Science. 2010; 51:1956–1964. https://doi.org/10.1167/iovs.09-4280
Ong K, Ong L, Ong L. Corneal endothelial changes after selective laser trabeculoplasty. Clinical and Experimental Ophthalmology. 2013;41(6):537– 540. https://doi.org/10.1111/ceo.12068
Hurmeric V, Sahin A, Ozge G, Bayer A. The relationship between corneal biomechanical properties and confocal microscopy findings in normal and keratoconic eyes. Cornea. 2010;29(6):641–649. https://doi.org/10.1097/ico.0b013e3181c11dc6