Effectiveness of a nonsteroidal anti-inflammatory drug in the treatment of chronic non-infectious blepharitis

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Anti-inflammatory therapy is a type of etiopathogenetic treatment of chronic mixed blepharitis. Nonsteroidal anti-inflammatory drugs (NSAIDs) have pronounced anti-inflammatory effect comparable to the action of corticosteroids. Purpose — to assess of the effectiveness of a NSAID — 0.09% bromfenac — in the treatment of chronic blepharitis of non-infectious etiology. Material and methods. The study included 37 patients (74 eyes), 31 women (62 eyes) and 6 men (12 eyes) with chronic blepharitis. All patients underwent clinical, functional, instrumental and laboratory examination. The treatment of patients of the main group consisted of instillations of 0.09% bromfenac («Broxinac», Sentiss, India) once per day and artificial tears with lipid component 3 times a day for 30 days. Patients in the control group only used artificial tears with lipid component 3 times a day for 30 days. The follow-up included examinations at one week, one and two months. Results. The positive clinical and functional response after treatment corresponded to optimization of the state of microvasculature in both groups, however, the dynamics of changes in the control group were less pronounced. Conclusion. Elimination of microcirculatory disorders in the eyelids and signs of inflammation of the ocular surface determine the etiopathogenetic direction of using 0.09% bromfenac in the conservative treatment of chronic mixed blepharitis.

Keywords:

bromfenac

blepharitis

microcirculation

laser Doppler flowmetry

Authors:

Safonova T.N.

FGBU "NII glaznykh bolezneĭ" RAMN, Moskva

Kintukhina N.P.

Research Institute of Eye Diseases, 11 A, B, Rossolimo St., Moscow, Russian Federation, 119021

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