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Sdobnikova S.V.

FGBU "NII glaznykh bolezneĭ" RAMN, Moskva

Kulybysheva V.S.

Research Institute of Eye Diseases, 11A Rossolimo St., Moscow, Russian Federation, 119021

Sidamonidze A.L.

FGBU "NII glaznykh bolezneĭ" RAMN, Moskva

The state of ocular neurosensory apparatus in diabetes mellitus

Authors:

Sdobnikova S.V., Kulybysheva V.S., Sidamonidze A.L.

More about the authors

Journal: Russian Annals of Ophthalmology. 2018;134(5): 263‑269

DOI: 10.17116/oftalma2018134051263

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Table of contents

THE STATE OF OCULAR NEUROSENSORY APPARATUS IN DIABETES MELLITUS
THE STATE OF OCULAR NEUROSENSORY APPARATUS IN DIABETES MELLITUS

To cite this article:

Sdobnikova SV, Kulybysheva VS, Sidamonidze AL. The state of ocular neurosensory apparatus in diabetes mellitus. Russian Annals of Ophthalmology. 2018;134(5):263‑269. (In Russ.)
https://doi.org/10.17116/oftalma2018134051263

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)
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Abstract:

Diabetes mellitus is one of the most common chronic diseases in the world. Among its late complications that can lead to disability is diabetic neuropathy (DN). Patients diagnosed with DN often also have diabetic retinopathy (DR). According to available data, DR prevalence ranges from 30 to 60%. For a long time, DR has been considered a microvascular disease. However, more data has been emerging recently that indicates the presence of other components in the pathophysiology of DR. Neurodegenerative changes in the retina can be detected in patients with diabetes mellitus before clinical signs of diabetic retinopathy appear. Accumulation of extracellular glutamate, oxidative stress, reduction of neuroprotective factors synthesized by the retina are all believed to lead to neuronal apoptosis and glial cell dysfunction. This cascade of reactions subsequently causes disruption of the hematoretinal barrier and damage to neurovascular apparatus of the retina. This results in the defeat of capillaries of the retinal vascular system, which is consistently characterized by the loss of pericytes and the formation of unperfusable capillaries. The concept of neurodegeneration being an early component of DR provides an opportunity to explore alternative therapies to prevent the onset of vision loss in diabetes mellitus.

Keywords:

diabetes mellitus
diabetic retinopathy
neurodegeneration
neuronal apoptosis
microvascular lesion
ocular neurosensory apparatus

Authors:

Sdobnikova S.V.

FGBU "NII glaznykh bolezneĭ" RAMN, Moskva

Kulybysheva V.S.

Research Institute of Eye Diseases, 11A Rossolimo St., Moscow, Russian Federation, 119021

Sidamonidze A.L.

FGBU "NII glaznykh bolezneĭ" RAMN, Moskva

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