Diabetes mellitus is associated with dangerous vascular complications, including diabetic retinopathy (DR), which can lead to complete visionloss. Modern diagnostic methods, such as optical coherent tomography, help accurately and objectively verify the stage of DR, thus providing an opportunity to choose a treatment algorithm able to prevent further progression of the disease. The aim of the study was to investigate the efficacy of antioxidant therapy (Vitrum Vision Forte and Vitrum Memory) as the initial phase of treatment of non-proliferative DR in type 2 diabetes, what is pathogenically reasonable due to involved oxidative stress.