Molecular genetic aspects of glaucoma pathogenesis

Boĭko É.V.; Churashov S.V.; Kamilova T.A.

doi:https://doi.org/

Boĭko É.V.

Kafedra oftal'mologii Voenno-meditsinskoĭ akademii im. S.M. Kirova, Sankt-Peterburg

Churashov S.V.

Kafedra oftal'mologii Voenno-meditsinskoĭ akademii im. S.M. Kirova, Sankt-Peterburg

Kamilova T.A.

Kafedra oftal'mologii Voenno-meditsinskoĭ akademii im. S.M. Kirova, Sankt-Peterburg

Molecular genetic aspects of glaucoma pathogenesis

Authors:

Boĭko É.V., Churashov S.V., Kamilova T.A.

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Journal: Russian Annals of Ophthalmology. 2013;129(4): 76‑82

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To cite this article:

Boĭko ÉV, Churashov SV, Kamilova TA. Molecular genetic aspects of glaucoma pathogenesis. Russian Annals of Ophthalmology. 2013;129(4):76‑82. (In Russ.)

Подписка 2026 Вестник офтальмологии (Russian Annals of Ophthalmology)

Использование инфографики авторами научных работ

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Abstract:

To improve our understanding of glaucoma pathophysiology it is important to investigate endophenotypes which are determined by heritable quantitative traits, such as intraocular pressure, vertical cup-to-disc ratio, optic disc area, and central corneal thickness. Glaucoma is associated with increased intraocular pressure and defects of trabecular meshwork and anterior chamber which lead to derangement of intraocular fluid outflow, progressive optic nerve degeneration, loss of nerve cells, and blindness. Factors that are not affected by intraocular pressure also contribute to glaucoma degeneration. In progressive degenerative diseases, such as glaucoma, chronic astrocyte activation exacerbates the damage to neurons and impairs the regeneration of their axons. This review considers the polymorphism of predisposition factors to glaucoma-associated endophenotypes, optic nerve degeneration, and side effects of antiglaucomatous drugs.

Keywords:

glaucoma

optic nerve

genetic predisposition

polymorphism

pharmacogenetics

Authors:

Boĭko É.V.

Kafedra oftal'mologii Voenno-meditsinskoĭ akademii im. S.M. Kirova, Sankt-Peterburg

Churashov S.V.

Kafedra oftal'mologii Voenno-meditsinskoĭ akademii im. S.M. Kirova, Sankt-Peterburg

Kamilova T.A.

Kafedra oftal'mologii Voenno-meditsinskoĭ akademii im. S.M. Kirova, Sankt-Peterburg

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References:

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