The proapoptotic р53(С72G) and р21(С31А) polymorphisms as the risk factors for the development of primary open-angle glaucoma in Transbaikalian region

Logunov N.A.

GOU VPO "Chitinskaia gosudarstvennaia meditsinskaia akademiia" Minzdravsotsrazvitiia Rossii

Belousova A.I.

GOU VPO "Chitinskaia gosudarstvennaia meditsinskaia akademiia" Minzdravsotsrazvitiia Rossii

Vitkovskiĭ Iu.A.

GOU VPO "Chitinskaia gosudarstvennaia meditsinskaia akademiia" Minzdravsotsrazvitiia Rossii

The proapoptotic р53(С72G) and р21(С31А) polymorphisms as the risk factors for the development of primary open-angle glaucoma in Transbaikalian region

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Logunov N.A., Belousova A.I., Vitkovskiĭ Iu.A.

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Journal: Russian Annals of Ophthalmology. 2012;128(5): 10‑13

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Logunov NA, Belousova AI, Vitkovskiĭ IuA. The proapoptotic р53(С72G) and р21(С31А) polymorphisms as the risk factors for the development of primary open-angle glaucoma in Transbaikalian region. Russian Annals of Ophthalmology. 2012;128(5):10‑13. (In Russ.)

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The incidence of p53(C72G) and p21(C31A) proapoptotic polymorphisms is studied in Russian and Buryat population of Transbaicalian region and prognostic value of these polymorphisms in development of primary open-angle glaucoma (POAG) is assessed. Significant difference in incidence of p53 and p21 was found between healthy subjects and glaucoma patients in both ethnic groups. The incidence of C and G variants of p53-gene and C and A variants of p21-gene differ in glaucoma patients and healthy subjects. The study lets us propose that p53(C72G) and p21(C31A) polymorphisms contribute to the risk of POAG onset in Russian and Buryat population as well.

Keywords:

apoptosis

glaucoma

genetics

polymorphism

Authors:

Logunov N.A.

GOU VPO "Chitinskaia gosudarstvennaia meditsinskaia akademiia" Minzdravsotsrazvitiia Rossii

Belousova A.I.

GOU VPO "Chitinskaia gosudarstvennaia meditsinskaia akademiia" Minzdravsotsrazvitiia Rossii

Vitkovskiĭ Iu.A.

GOU VPO "Chitinskaia gosudarstvennaia meditsinskaia akademiia" Minzdravsotsrazvitiia Rossii

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