Genetic determinants of hypertension in two national cohorts of Mountain Shoria

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Aim. To estimate the prevalence of the genotypes of the candidate genes ACE (I/D, rs4646994), ADRB1 (Ser49Gly, A/G, rs1801252) ADRA2B (I/D), MTHFR (C677T, Ala222Val, rs1801133), and eNOS (4b/4a) and their association with hypertension in two ethnic groups of Mountain Shoria. Subjects and methods. A clinical and epidemiological study was conducted in a population compactly living in the hard-to-reach areas of Mountain Shoria (the settlements of Orton, Ust-Kabyrza, and Sheregesh of the Kemerovo Region). A continuous method was used to survey 1178 residents from the above settlements; the sample consisted of adults (aged 18 years and older), 565 people were genotyped. Results. The prevalence of hypertension among the population of Mountain Shoria was 42.3%. The incidence of this disease among the Shorians was lower (39.9%) than that among the representatives of non-indigenous people (46.1%). The ethnically justified peculiarities of the association of ADRA2B and ACE I/D polymorphisms with hypertension were established. There were fewer patients with hypertension among ACE ID and ADRA2B DD genotype carriers in the cohort of the Shorians than in that of the non-indigenous population: 40.6% versus 58.6% and 38.3% versus 64%, respectively. Conversely, there were more hypertensive patients among the carriers of the homozygous ACE DD genotype in the native ethnic group (60%) than in the non-indigenous one (37.1%). Conclusion. Adverse prognostic ACE DD, ADRB1 AA, MTHFR TT, and eNOS 4a/4a genotypes were more frequently observed in the non-indigenous ethnic groups; the ADRA2B DD genotype was more common in the native population. Hypertension was associated with the ACE DD, МTHFR CT, and ADRB1 AA genotypes in the native ethnic group and with the ACE ID genotype in the non-indigenous population.

Keywords:

ethnos

hypertension

candidate genes

associations

I/D polymorphism

endothelial synthase gene

Authors:

Barbarash O.L.

Kemerovskaia oblastnaia klinicheskaia bol'nitsa

SPIN RSCI: 5373-7620
Scopus AuthorID: 56699731800
ResearcherID: A-4834-2017
ORCID: 0000-0002-4642-3610

Voevoda M.I.

Research Institute of Therapy and Prophylactic Medicine, Siberian Branch of the Russian Academy of Medical Sciences;
City Clinical Hospital No1, Novosibirsk, Russia

Artamonova G.V.

Institution Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo

SPIN RSCI: 3972-2791
Scopus AuthorID: 36980033200
ResearcherID: S-6079-2016
ORCID: 0000-0003-2279-3307

Mulerova T.A.

FGBU "Nauchno-issledovatel'skiĭ institut kompleksnykh problem serdechno-sosudistykh zabolevaniĭ" SO RAMN, Kemerovo

Voropaeva Е.N.

Research Institute of Internal and Preventive Medicine, Novosibirsk, Russia

Maksimov V.N.

Research Institute of Therapy, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk

Ogarkov M.Iu.

Novokuznetskiĭ gosudarstvennyĭ institut usovershenstvovaniia vracheĭ Minzdrava Rossii

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