Study of the effectiveness of the drug Elcarnitine in the correction of increased variability of arterial pressure in patients with hypertensive disease and cognitive dysfunction

Ryabov A.A.; Akimova N.S.; Parkhonuk E.V.; Shvarts Y.G.

doi:https://doi.org/10.17116/profmed20252810188

Ryabov A.A.

Saratov State Medical University named after V.I. Razumovsky

ORCID: 0009-0006-5399-4469

Akimova N.S.

Saratov State Medical University named after V.I. Razumovsky

ORCID: 0000-0003-3561-5059

Parkhonuk E.V.

Saratov State Medical University named after V.I. Razumovsky

ORCID: 0000-0001-7496-4011

Shvarts Y.G.

Saratov State Medical University named after V.I. Razumovsky

ORCID: 0000-0002-5205-7311

Study of the effectiveness of the drug Elcarnitine in the correction of increased variability of arterial pressure in patients with hypertensive disease and cognitive dysfunction

Authors:

Ryabov A.A., Akimova N.S., Parkhonuk E.V., Shvarts Y.G.

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Journal: Russian Journal of Preventive Medicine. 2025;28(10): 88‑92

DOI: 10.17116/profmed20252810188

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To cite this article:

Ryabov AA, Akimova NS, Parkhonuk EV, Shvarts YG. Study of the effectiveness of the drug Elcarnitine in the correction of increased variability of arterial pressure in patients with hypertensive disease and cognitive dysfunction. Russian Journal of Preventive Medicine. 2025;28(10):88‑92. (In Russ.)
https://doi.org/10.17116/profmed20252810188

Подписка 2026 Профилактическая медицина (Russian Journal of Preventive Medicine)

Использование инфографики авторами научных работ

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OBJECTIVE

To assess the efficacy of L-carnitine for the treatment of increased blood pressure variability in patients with hypertension.

MATERIALS AND METHODS

A simple, double-blind, placebo-controlled study was conducted involving 116 patients with hypertension, including 30 patients with increased daily blood pressure variability and moderate cognitive impairment, aged between 50 and 70 years. Participants were randomly assigned (randomization 2:1 using a random number table generated in Excel) into two groups. Patients in the experimental group (n=70) received levocarnitine at a dose of 1000 mg intravenously once a day for 10 days. Patients in the control group (n=34) received an intravenous drip solution containing 0.9% sodium chloride 200.0 ml, 4% potassium chloride 10.0 ml, and 25% magnesium sulfate 10.0 ml daily. During Visit 1 (screening) and Visit 2 (final visit), all study participants underwent electrocardiography, 24-hour blood pressure monitoring, and cognitive function assessments using Wechsler subtests 5 and 7, the Bourdon proofreading test, and the assessment of the asthenia vegetative index using the MFI-20 scale. A multifactorial analysis of variance (ANOVA) was performed using Statistica 10.0 software.

RESULTS

Patients in the test group, compared to those in the control group, had significantly reduced variability in systolic and diastolic blood pressure over both day and night. The observed effect of L-carnitine on BPV may be due to its effect on the autonomic nervous system.

CONCLUSION

L-carnitine may be effective in the treatment of increased blood pressure variability in patients with hypertension.

Keywords:

L-carnitine

hypertension

blood pressure variability

cardiovascular diseases

Authors:

Ryabov A.A.

Saratov State Medical University named after V.I. Razumovsky

ORCID: 0009-0006-5399-4469

Akimova N.S.

Saratov State Medical University named after V.I. Razumovsky

ORCID: 0000-0003-3561-5059

Parkhonuk E.V.

Saratov State Medical University named after V.I. Razumovsky

ORCID: 0000-0001-7496-4011

Shvarts Y.G.

Saratov State Medical University named after V.I. Razumovsky

ORCID: 0000-0002-5205-7311

Received:

10.07.2025

Accepted:

10.10.2025

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References:

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