The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Krylov M.Yu.

V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia

Anan'eva L.P.

FGBNU «NII revmatologii im. V.A. Nasonovoj», Moskva

Koneva О.А.

V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia

Starovoytova M.N.

V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia

Desinova O.V.

V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia

Ovsyannikova O.B.

V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia

Aleksandrova E.N.

"Research Institute of rheumatology n. a. V. A. Nasonova"

Novikov A.A.

"Research Institute of rheumatology n. a. V. A. Nasonova"

Guseva I.A.

Research Institute of Rheumatology named after V.N. Nasonova, 34a Kashirskoe Shosse, Moscow, Russian Federation, 115522

Konovalova N.V.

«Sintol» Closed Joint-Stock Company, Moscow, Russia, 127550

Varlamov D.A.

All-Russian Research Institute of Agricultural Biotechnology, Moscow, Russia

The influence of STAT4 rs7574865 (G/T) polymorphism on the risk of clinical and immunological phenotypes of systemic sclerosis in a Russian patient population: Results of a pilot study

Authors:

Krylov M.Yu., Anan'eva L.P., Koneva О.А., Starovoytova M.N., Desinova O.V., Ovsyannikova O.B., Aleksandrova E.N., Novikov A.A., Guseva I.A., Konovalova N.V., Varlamov D.A.

More about the authors

Journal: Therapeutic Archive. 2017;89(5): 20‑25

DOI: 10.17116/terarkh201789520-25

Read: 2981 times

Download PDF (RU)
Contact the author
Table of contents

THE INFLUENCE OF STAT4 RS7574865 (G/T) POLYMORPHISM ON THE RISK OF CLINICAL AND IMMUNOLOGICAL PHENOTYPES OF SYSTEMIC SCLEROSIS IN A RUSSIAN PATIENT POPULATION: RESULTS OF A PILOT STUDY
THE INFLUENCE OF STAT4 RS7574865 (G/T) POLYMORPHISM ON THE RISK OF CLINICAL AND IMMUNOLOGICAL PHENOTYPES OF SYSTEMIC SCLEROSIS IN A RUSSIAN PATIENT POPULATION: RESULTS OF A PILOT STUDY

To cite this article:

Krylov MYu, Anan'eva LP, Koneva ОА, et al. . The influence of STAT4 rs7574865 (G/T) polymorphism on the risk of clinical and immunological phenotypes of systemic sclerosis in a Russian patient population: Results of a pilot study. Therapeutic Archive. 2017;89(5):20‑25. (In Russ.)
https://doi.org/10.17116/terarkh201789520-25

МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Abstract:

Aim. To examine the association of signal transducer and activator transcription 4 (STAT4) rs7574865 G/T polymorphism with a predisposition to systemic sclerosis (SSC) and associated clinical and autoimmune phenotypes in a Russian population. Subjects and methods. A total of 102 patients with SSC and 103 healthy individuals as controls were examined. STAT4 rs7574865 polymorphism was investigated by real-time polymerase chain reaction. Results. The carriers of the T allele showed a statistically significant association with SSC, a diffuse form (DF), the presence of interstitial lung disease (ILD), cardiac injury (CI), and seropositivity for anti-topoisomerase I antibodies (ATA). Conclusion. The findings results confirm the important role of STAT4 gene in the predisposition to SSC and its phenotypes, such as DF, ILD, CI, and ATA in the Russian population.

Keywords:

systemic sclerosis
genetics
polymorphism
STAT4 gene
population

Authors:

Krylov M.Yu.

V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia

Anan'eva L.P.

FGBNU «NII revmatologii im. V.A. Nasonovoj», Moskva

Koneva О.А.

V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia

Starovoytova M.N.

V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia

Desinova O.V.

V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia

Ovsyannikova O.B.

V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia

Aleksandrova E.N.

"Research Institute of rheumatology n. a. V. A. Nasonova"

Novikov A.A.

"Research Institute of rheumatology n. a. V. A. Nasonova"

Guseva I.A.

Research Institute of Rheumatology named after V.N. Nasonova, 34a Kashirskoe Shosse, Moscow, Russian Federation, 115522

Konovalova N.V.

«Sintol» Closed Joint-Stock Company, Moscow, Russia, 127550

Varlamov D.A.

All-Russian Research Institute of Agricultural Biotechnology, Moscow, Russia

Close metadata

References:

  1. Stephanie GY, Kong J, Cheema GS, Keen CL, Wick G, Gershwin ME. The immunobiology of systemic sclerosis. Semin Arthritis Rheum. 2008;38:132-160. doi:10.1016/j.semarthrit.2007.10.010
  2. Harley JB, Alarcon-Riquelme ME, Criswell LA, Jacob CO, Kimberly RP, Moser KL, et al. Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nat Genet. 2008;40:204-210. doi:10.1016/j.clim.2008.03.252
  3. Korman BD, Alba MI, Le JM, Alevizos I, Smith JA, Nikolov NP, et al. Variant form of STAT4 is associated with primary Sjo¨gren’s syndrome. Genes Immun. 2008;9:267-270. doi:10.1038/gene.2008.1
  4. Martinez A, Varade J, Marquez A, Cenit MC, Espino L, Perdigones N, et al. Association of the STAT4 gene with increased susceptibility for some immune-mediated diseases. Arthritis Rheum. 2008; 58:2598-2602. doi:10.1002/art.23792
  5. Remmers EF, Plenge RM, Lee AT, Graham RR, Hom G, Behrens TW, et al. STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus. N Engl J Med. 2007;357:977-986. doi:10.1056/nejmoa073003
  6. Kobayashi S, Ikari K, Kaneko H, Kochi Y, Yamamoto K, Shimane K, et al. Association of STAT4 with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in the Japanese population. Arthritis Rheum. 2008;58:1940-1946. doi:10.1002/art.23494
  7. Lee HS, Remmers EF, Le JM, Kastner DL, Bae SC, Gregersen PK. Association of STAT4 with rheumatoid arthritis in the Korean population. Mol Med. 2007;13:455-460. doi:10.2119/2007-00072.Lee
  8. Watford WT, Hissong BD, Bream JH, Kanno Y, Muul L, O’Shea JJ. Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4. Immunol Rev. 2004;202:139-156. doi:10.1111/j.0105-2896.2004.00211x
  9. Sigurdsson S, Nordmark G, Garnier S, Grundberg E, Kwan T, Nilsson O, et al. A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5. Hum Mol Genet. 2008;17:2868-2876. doi:10.1093/hmg/ddn184
  10. Varga J, Abraham D. Systemic sclerosis: a prototypic multisystem fibrotic disorder. J Clin Invest. 2007;117:557-567. doi:10.1172/JCI31139
  11. Bunn CC, Black CM. Systemic sclerosis: an autoantibody mosaic. Clin ExpImmunol. 1999;117:207. doi:10.1046/j.1365-2249.1999.00990.x
  12. Steen VD. Autoantibodies in systemic sclerosis. Semin Arthritis Rheum. 2005;35:35-42. doi:10.1016/j.semarthrit.2005.03.005
  13. Arnett FC, Howard RF, Tan F, et al. Increased prevalence of systemic sclerosis in a Native American tribe in Oklahoma. Association with an Amerindian HLA haplotype. Arthritis Rheum. 1996;39:1362-1370. doi:10.1002/art.1780390814
  14. Steen V, Domsic RT, Lucas M, Fertig N, Medsger TA. A clinical and serologic comparison of African-American and Caucasian patients with systemic sclerosis. Arthritis Rheum. 2012;64(9):2986-2995. doi:10.1002/art.34482
  15. Wang J, Assassi S, Guo G, et al. Clinical and serological features of systemic sclerosis in a Chinese cohort. Clin Rheumatol. 2013;32(5):617-621. doi:10.1007/s10067-012-2145-7
  16. Radstake TR, Gorlova O, Rueda B, et al. Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus. Nat Genet. 2010;42(5):426-429. doi:10.1038/ng.565
  17. Thierfelder WE, van Deursen JM, Yamamoto K, et al. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature. 1996;382(6487):171-174. doi:10.1038/382171a0
  18. Rueda B, Broen J, Simeon C, et al. The STAT4 gene influences the genetic predisposition to systemic sclerosis phenotype. Hum Mol Genet. 2009; 18:2071-2077. doi:10.1093/hmg/ddp119
  19. Tsuchiya N, Kawasaki A, Hasegawa M, et al. Association of STAT4 polymorphism with systemic sclerosis in a Japanese population. Ann Rheum Dis. 2009;68(8):1375-1376. doi:10.1136/ard.2009.111310
  20. Yi L,Wang JC, Guo XJ, Gu YH et al. STAT4 is a genetic risk factor for systemic sclerosis in a Chinese population. Int J Immunopathol Pharmacol. 2013;26(2):473-478.
  21. Fukao T, Frucht DM, Yap G, Gadina M, O’Shea JJ, Koyasu S. Inducible expression of Stat4 in dendritic cells and macrophages and its critical role in innate and adaptive immune responses. J Immunol. 2001;166:4446-4455. doi:10.4049/jimmunol.166.7.4446
  22. Avouac J, Fürnrohr BG, Tomcik M, et al. Inactivation of the transcription factor STAT-4 prevents inflammation-driven fibrosis in animal models of systemic sclerosis. Arthritis Rheum. 2011;63:800-809. doi:10.1002/art.30171
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.