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Krylov M.Yu.

V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia

Anan'eva L.P.

FGBNU «NII revmatologii im. V.A. Nasonovoj», Moskva

Koneva О.А.

V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia

Starovoytova M.N.

V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia

Desinova O.V.

V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia

Ovsyannikova O.B.

V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia

Aleksandrova E.N.

"Research Institute of rheumatology n. a. V. A. Nasonova"

Novikov A.A.

"Research Institute of rheumatology n. a. V. A. Nasonova"

Guseva I.A.

Research Institute of Rheumatology named after V.N. Nasonova, 34a Kashirskoe Shosse, Moscow, Russian Federation, 115522

Konovalova N.V.

«Sintol» Closed Joint-Stock Company, Moscow, Russia, 127550

Varlamov D.A.

All-Russian Research Institute of Agricultural Biotechnology, Moscow, Russia

The influence of STAT4 rs7574865 (G/T) polymorphism on the risk of clinical and immunological phenotypes of systemic sclerosis in a Russian patient population: Results of a pilot study

Authors:

Krylov M.Yu., Anan'eva L.P., Koneva О.А., Starovoytova M.N., Desinova O.V., Ovsyannikova O.B., Aleksandrova E.N., Novikov A.A., Guseva I.A., Konovalova N.V., Varlamov D.A.

More about the authors

Journal: Therapeutic Archive. 2017;89(5): 20‑25

DOI: 10.17116/terarkh201789520-25

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Table of contents

THE INFLUENCE OF STAT4 RS7574865 (G/T) POLYMORPHISM ON THE RISK OF CLINICAL AND IMMUNOLOGICAL PHENOTYPES OF SYSTEMIC SCLEROSIS IN A RUSSIAN PATIENT POPULATION: RESULTS OF A PILOT STUDY
THE INFLUENCE OF STAT4 RS7574865 (G/T) POLYMORPHISM ON THE RISK OF CLINICAL AND IMMUNOLOGICAL PHENOTYPES OF SYSTEMIC SCLEROSIS IN A RUSSIAN PATIENT POPULATION: RESULTS OF A PILOT STUDY

To cite this article:

Krylov MYu, Anan'eva LP, Koneva ОА, et al. . The influence of STAT4 rs7574865 (G/T) polymorphism on the risk of clinical and immunological phenotypes of systemic sclerosis in a Russian patient population: Results of a pilot study. Therapeutic Archive. 2017;89(5):20‑25. (In Russ.)
https://doi.org/10.17116/terarkh201789520-25

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Aim. To examine the association of signal transducer and activator transcription 4 (STAT4) rs7574865 G/T polymorphism with a predisposition to systemic sclerosis (SSC) and associated clinical and autoimmune phenotypes in a Russian population. Subjects and methods. A total of 102 patients with SSC and 103 healthy individuals as controls were examined. STAT4 rs7574865 polymorphism was investigated by real-time polymerase chain reaction. Results. The carriers of the T allele showed a statistically significant association with SSC, a diffuse form (DF), the presence of interstitial lung disease (ILD), cardiac injury (CI), and seropositivity for anti-topoisomerase I antibodies (ATA). Conclusion. The findings results confirm the important role of STAT4 gene in the predisposition to SSC and its phenotypes, such as DF, ILD, CI, and ATA in the Russian population.

Keywords:

systemic sclerosis
genetics
polymorphism
STAT4 gene
population

Authors:

Krylov M.Yu.

V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia

Anan'eva L.P.

FGBNU «NII revmatologii im. V.A. Nasonovoj», Moskva

Koneva О.А.

V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia

Starovoytova M.N.

V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia

Desinova O.V.

V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia

Ovsyannikova O.B.

V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia

Aleksandrova E.N.

"Research Institute of rheumatology n. a. V. A. Nasonova"

Novikov A.A.

"Research Institute of rheumatology n. a. V. A. Nasonova"

Guseva I.A.

Research Institute of Rheumatology named after V.N. Nasonova, 34a Kashirskoe Shosse, Moscow, Russian Federation, 115522

Konovalova N.V.

«Sintol» Closed Joint-Stock Company, Moscow, Russia, 127550

Varlamov D.A.

All-Russian Research Institute of Agricultural Biotechnology, Moscow, Russia

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