The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Solovyeva I.A.

Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia, Krasnoyarsk, Russia

Sobko E.A.

Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia, Krasnoyarsk, Russia;
Territorial Clinical Hospital, Krasnoyarsk, Russia

Demko I.V.

GBOU VPO "Krasnoiarskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. prof. V.F. Voĭno-Iasenetskogo" Minzdrava Rossii

Kraposhina A.Yu.

Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia, Krasnoyarsk, Russia

Gordeeva N.V.

Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia, Krasnoyarsk, Russia;
Krasnoyarsk Territorial Hospital, Krasnoyarsk, Russia

Loktionova M.M.

Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia, Krasnoyarsk, Russia;
Krasnoyarsk Territorial Hospital, Krasnoyarsk, Russia

Asthma and obesity

Authors:

Solovyeva I.A., Sobko E.A., Demko I.V., Kraposhina A.Yu., Gordeeva N.V., Loktionova M.M.

More about the authors

Journal: Therapeutic Archive. 2017;89(3): 116‑120

DOI: 10.17116/terarkh2017893116-120

Read: 4837 times

Download PDF (RU)
Contact the author
Table of contents

ASTHMA AND OBESITY
ASTHMA AND OBESITY

To cite this article:

Solovyeva IA, Sobko EA, Demko IV, Kraposhina AYu, Gordeeva NV, Loktionova MM. Asthma and obesity. Therapeutic Archive. 2017;89(3):116‑120. (In Russ.)
https://doi.org/10.17116/terarkh2017893116-120

МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Comparative analysis of the state of the microvasculature of the oral mucosa in persons with meta­bolic syndrome in the aspect of orthopedic dental reha­bilitation. Stomatology. 2024;(6-2):15-22
Chro­nic inflammation in case of obesity-associated diseases. Russian Journal of Preventive Medi­cine. 2025;(1):115-121
Identification of prognostic significant markers of early diagnosis of obesity and meta­bolic diso­rders. Problems of Balneology, Physiotherapy and Exercise Therapy. 2024;(6-2):71-79
Possibilities of using meldonium as part of complex therapy in patients with ischemic heart disease and chro­nic heart failure combined with obesity. Russian Journal of Cardiology and Cardiovascular Surgery. 2025;(1):53-60
Safety asse­ssment of bariatric surgery in the Russian Fede­ration acco­rding to the Russian National Bariatric Regi­stry. Endo­scopic Surgery. 2025;(1):5-14
Adipocytokines as a predictor of the risk of adve­rse outcomes in patients with coro­nary heart disease and abdo­minal obesity after percutaneous coro­nary inte­rvention. Russian Journal of Preventive Medi­cine. 2025;(2):38-45
Characteristics of the myocardial stru­ctural and functional para­meters depe­nding on the meta­bolic phenotype of the Arkhangelsk city resi­dents. Russian Journal of Preventive Medi­cine. 2025;(2):53-60
Serum concentrations of irisin, erythroferrone, myostatin and inte­rleukin-6 in obese patients depe­nding on the presence of sarcopenia. Russian Journal of Preventive Medi­cine. 2025;(2):67-73
The effe­ctiveness evaluation of a single primary moti­vational counseling in patients with obesity and cardiovascular diseases. Russian Journal of Preventive Medi­cine. 2025;(2):80-86
Immu­notherapy in the treatment of chro­nic poly­pous rhinosinusitis with como­rbid bronchial asthma. Russian Bulletin of Otorhinolaryngology. 2025;(1):29-34
Abstract:

The problem of modern medicine is to optimize the treatment of patients with comorbidity, whose number has been growing steadily in recent years. The concurrence of asthma and obesity determines the severity of disease, low-level control, and resistance to basic therapy in conjunction with more frequent use of β-agonists for relief of symptoms, and frequent hospitalizations for a disease exacerbation. Currently, there are only a few known pathogenetic components that are responsible for the negative impact of visceral obesity on the course of asthma.

Keywords:

asthma
obesity
adipokines

Authors:

Solovyeva I.A.

Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia, Krasnoyarsk, Russia

Sobko E.A.

Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia, Krasnoyarsk, Russia;
Territorial Clinical Hospital, Krasnoyarsk, Russia

Demko I.V.

GBOU VPO "Krasnoiarskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. prof. V.F. Voĭno-Iasenetskogo" Minzdrava Rossii

Kraposhina A.Yu.

Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia, Krasnoyarsk, Russia

Gordeeva N.V.

Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia, Krasnoyarsk, Russia;
Krasnoyarsk Territorial Hospital, Krasnoyarsk, Russia

Loktionova M.M.

Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia, Krasnoyarsk, Russia;
Krasnoyarsk Territorial Hospital, Krasnoyarsk, Russia

Close metadata

References:

  1. Lugogo NL, Kraft M, Dixon AE. Does obesity produce a distinct asthma phenotype? J Appl Physiol. 2010;108:729-734. doi:10.1152/japplphysiol.00845.2009
  2. Stenius-Aarniala B, Poussa T, Kvarnstrom J, Gronlund EL, Ylikahri M, Mustajoki P. Immediate and long term effects of weight reduction in obese people with asthma: randomized controlled study. BMJ. 2000;320:827-828.
  3. Dixon AE. Obesity: changing asthma in the 21st century. Am J Respir Crit Care Med. 2012;186(5):395-396. doi:10.1164/rccm.201206-1092ED
  4. Ogorodova LM, Kulikov ES, Timoshina EL. Obesity and bronchial asthma: new view (review). Terapevt. arkhiv. 2007;10:32-35.
  5. Anderson WJ, Lipworth BJ. Does body mass index influence responsiveness to inhaled corticosteroids in persistent asthma? Ann Allergy Asthma Immunol. 2012;108(4):237-242. doi:10.1016/j.anai.2011.12.006.
  6. Peters-Golden M, Swern A, Bird SS, Hustad CM, Grant E, Edelman JM. Influence of body mass index on the response to asthma controller agents. Eur Respir J. 2006;27:495-503.
  7. Boulet LP, Franssen E. Influence of obesity on response to fluticasone with or without salmeterol in moderate asthma. Respir Med. 2007;101:2240-2247.
  8. Sutherland ER, Goleva E, Strand M, Beuther DA, Leung DY. Body mass and glucocorticoid response in asthma. Am J Respir Crit Care Med. 2008;178:682-687. doi:10.1164/rccm.200801-076OC.
  9. Vollmer W, Markson L, O'Connor E, Sanocki LL, Fitterman L, Berger M, Buist AS. Association of asthma control with health care utilization and quality of life. Am J Respr Crit Care Med. 1999;160:1647-1652.
  10. Hakala K, Stenius-Aarniala B, Sovijarvi A. Effects of weight loss on peak flow variability, airways obstruction, and lung volumes in obese patients with asthma. Chest. 2000;118:1315-1321.
  11. Boykov VA, Kobyakova OS, Deev IA, Kulikov ES, Starovoytova EA. State of respiratory function in patients with obesity. Byul. sib. meditsiny. 2013;12(1):86-92.
  12. Yashina LA. Overweight, obesity and lung pathology: the opinion of the pulmonologist. Zdorov'ya Ukraini. 2011;2(14):14-15.
  13. Ibrahim MM. Subcutaneous and visceral adipose tissue: structural and functional differences. Obes Rev. 2009;11:11-18. doi:10.1111/j.1467-789X.2009.00623.x
  14. Beuther DA, Sutherland ER. Obesity and pulmonary function testing. J Allergy Clin Immunol. 2005;115:1100-1101.
  15. Lessard A, Alméras N, Turcotte H, Tremblay A, Després JP, Boulet LP. Adiposity and pulmonary function:relationship with body fat distribution and systemic inflammation. Clin Invest Med. 2011;34(2):64-70.
  16. Saxena Y, Sidhwani G, Upmanyu R. Abdominal obesity and pulmonary functions in young Indian adults: a prospective study. Indian J Physiol Pharmacol. 2009;53(4):318-326.
  17. Pertseva TA, Nud'ga NP. Asthma and obesity:kakova vzaimosvyaz'. Ukrain. pul'monol. zhurn. 2011;1:61-64.
  18. Astaf'eva NG, Gamova IV, Udovichenko EN, Perfilova IA. Obesity and bronchial asthma. Lechashchiy vrach. 2014;4:8-12.
  19. Yashina LA, Ishchuk SG. Bronchial asthma at patients with obesity — particular rhenotype of the disease. Astma ta alergiya. 2011;4:46-49.
  20. Van den Berge M, ten Hacken NH, Cohen J, Douma WR, Postma DS. Small airway disease in asthma and COPD: clinical implications. Chest 2011;139:412-423. doi:10.1378/chest.10-1210
  21. Scichilone N, Battaglia S, Olivieri D, Bellia V. The role of small airways in monitoring the response to asthma treatment: what is beyond FEV1. Allergy. 2009;64:1563. doi:10.1111/j.1398-9995.2009.02139.x
  22. Paraskakis E, Brindicci C, Fleming L, Krol R, Kharitonov SA, Wilson NM, Barnes PJ, Bush A. Measurement of bronchial and alveolar nitric oxide production in normal children and children with asthma. Am J Respir Crit Care Med. 2006;174:260-267.
  23. Budnevskiy AV, Ovsyannikov ES, Labzhaniya NB, Zhusina YuG. Small respiratory tracts:a role in formation of symptoms of bronchial asthma. It is international scientifically Paradigma school. Lyato-2015. Meditsina. 2015;7:32-40.
  24. Stenius-Aarniala B, Poussa T, Kvarnström J, Grönlund EL, Ylikahri M, Mustajoki P. Immediate and long term effects of weight reduction in obese people with asthma: randomized controlled study. BMJ. 2000;320(7238):827-832.
  25. Pіvovarova OA, Man'kovs'kiy BM. Porushennya funktsіonal'nogo stanu respіratornogo vіddіlu legen' u khvorikh na tsukroviy dіabet 2 tipu ta metabolіchniy sindrom (oglyad lіteraturi). Endokrinologіya. 2007;12(1):126-135.
  26. Kudelya LM, Sidorova LD, Mel'nikova EM, Mozhina LN, Popova NV. Experience of use of inductors of an interferon in complex therapy of patients with bronchial asthma in combination with a chronic obstructive pulmonary disease. Sibirskiy konsilium. 2008;1(64):20-21.
  27. Ketlinskiy SA. Role of T-helpers of types 1 and 2 in a regulation of cellular and humoral immunity. Immunologiya. 2002;23(2):77-79.
  28. Pecherova OV, Bednyakova AB, Polunina OS, Voronina LP, Nurzhanova IV. Cytokines balance in bronchial sathma. Trudy AGMA. Aktual'nye voprosy sovremennoy meditsiny. 2010;41(LXV):136-137.
  29. Sobko EA, Kraposhina AYu, Ishchenko OP, Demko IV. i dr. Interrelation of clinical and functional parameters, systemic inflammation in the development of arterial rigidity in patients with bronchial asthma. Byulleten' fiziologii i patologii dykhaniya. 2013;47:26-30.
  30. Sharvadze GG, Kurbatov DG, Poddubskaya EA, Mamedova MN. Hypoandrogen condition and cardiovascular diseases: actual questions of comorbidity in clinical practice. Ratsional'naya farmakoterapiya v kardiologii. 2010;6(4):532-538.
  31. Gusova ZR, Dzantieva EO, Khripun IA. Immunologicale aspects of obesity. Al'manakh klinicheskoy meditsiny. 2015;1:30-35.
  32. Payne GA, Kohr MC, Tune JD. Epicardial perivascular adipose tissue as a therapeutic target in obesity-related coronary artery disease. Br J Pharmacol. 2012;165(3):659-669. doi:10.1111/j.1476-5381.2011.01370.x
  33. Kosygina AB, Vasyukova OV. New evidence for the pathogenesis of obesity: adipokines are adipose tissue hormone. Problemy endokrinologii. 2009;55(1):44-50.
  34. Kuk JL, Ardern CI. Influence of age on the association between various measures of obesity and all-cause mortality. J Am Geriatr Soc. 2009;57(11):2077-2084. doi:10.1111/j.1532-5415.2009.02486.x
  35. Kershaw EE, Filer JS. Adipose tissue as an endocrineorgan. J Clin Endocrinol Metabol. 2004;89:2548-2556.
  36. Matsubara T, Mita A, Minami K. PGRN is a Key Adipokine Mediating High Fat Diet-Induced Insulin Resistance and Obesity through IL-6 in Adipose Tissue. Сell Metabol. 2012;15(1):38-50. doi:10.1016/j.cmet.2011.12.002
  37. Heijink IH et al. Interleukin-6 promotes the production of interleukin-4 and interleukin-5 by interleukin-2-dependent and -independent mechanisms in freshly isolated human T cells. Immunology. 2002;107:316-324.
  38. Frankhauser S, Elias I, Sopakis VR, et al. Overexpression of IL 6 leads to hyperinsulinemia, liver inflammation and reduced body weight in mice. Diabetologia. 2008;51:1306-1316. doi:10.1007/s00125-008-0998-8
  39. Wellen KE, Hotamisligil GS. Inflammation, stress and diabetes. J Clin Invest. 2005;115(5):1111-1119.
  40. Canöz M, Erdenen F, Uzun H. The relationship of inflammatory cytokines with asthma and obesity. Clin Invest Med. 2008;31(6):373-379.
  41. Arumalla VK, Kathyaini R. Serum high sensitivity C-reactive protein in different grades of obesity. Res J Pharm Biol Chem Sciences. 2011;2(4):1041.
  42. Eirmann LA, Freeman LM, Laflamme DP. Comparison of Adipokine Concentrations and Markers of Inflammation in Obese Versus Lean Dogs. Intern J Appl Res Vet Med. 2009;7(4):196-205.
  43. Antonyuk MV, Tsareva UV, Vitkina TI, Khodosova KK. State of the immune status in patients with bronchial asthma and obesity. Byulleten'. 2015;55:15-20.
  44. Green RH, Brightling CE, Woltmann G, Parker D, Wardlaw AJ, Pavord ID. Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids. Thorax. 2002;57:875.17.
  45. Berry M, Morgan A, Shaw DE, Parker D, Green R, Brightling C, Bradding P, Wardlaw AJ, Pavord ID. Pathological features and inhaled corticosteroid response of eosinophilic and non-eosinophilic asthma. Thorax. 2007;62:1043.
  46. Komakula S, Khatri S, Mermis J, Savill S, Haque S, Rojas M, Brown L, Teague GW, Holguin F. Body Mass Index is Associated with Reduced Exhaled Nitric Oxide and Higher Exhaled 8-Isoprostanes in Asthmatics. Respir Res. 2007;8:32.
  47. Shvarts VYa. Adipose tissue as an endocrine organ. Problemy endokrinologii. 2009;55(1):38-44.
  48. Sood А, Shore SA. Adiponectin, Leptin, and Resistin in Asthma. Basic Mechanisms through Population Studies Journal of Allergy. 2013;2013:785835. doi:10.1155/2013/785835.
  49. Caldefie-Chezet F, Poulin A, Tridon A et al. Leptin:a potential regulator of polymorphonuclear neutrophil bactericidal action? J Leuk Biology. 2001;69:414-418.
  50. De Rosa V, Procaccini C, Calì G, Pirozzi G, Fontana S, Zappacosta S, La Cava A, Matarese G. A key role of leptin in the control of regulatory T cell proliferation. Immunity. 2007;26(2):241-255.
  51. Wong CK, Cheung PF, Lam CW. Leptin-mediated cytokine release and migration of eosinophils: implications for immunopathophysiology of allergic inflammation. Eur J Immunol. 2007;37(8):2337-2348.
  52. Shore SA. Obesity and asthma: lessons from animal models. J Appl Physiol. 2007;102(2):516-528.
  53. Festa A, D'Agostino RJr, Williams K, Karter AJ, Mayer-Davis EJ, Tracy RP, Haffner SM. The relation of body fat mass and distribution to markers of chronic inflammation. Int J Obes Relat Metab Disord. 2001;25:1407-1415.
  54. Mineev VN, Lalaeva TM, Vasil'eva TS. Features of leptin signaling in bronchial asthma. Sbornik trudov VII Vserossiyskoy nauchno-prakticheskoy konferentsii «Zdorov'e — osnova chelovecheskogo potentsiala. Problemy i puti ikh resheniya». 2012;426-427.
  55. Mineev VN, Lalaeva TM, Vasil'eva TS, Kuz'mina AA. Adiponektin in blood plasma in bronchial asthma. Ural'skiy nauchnyy vestnik. 2014;34(113):34-41.
  56. Kadowaki T, Yamauchi T, Kubota N et al. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome J Clin Invest. 2006;116:1784-1792.
  57. Rossi A, Lord JM. Adiponectin inhibits neutrophil apoptosis via activation of AMP kinase, PKB and ERK 1/2 MAP kinase. Apoptosis 2013;18:1469-1480. doi:10.1007/s10495-013-0893-8
  58. Todd DC, Armstrong S, D’Silva L, Allen CJ, Hargreave FE, Parameswaran K. Effect of obesity on airway inflammation: a cross-sectional analysis of body mass index and sputum cell counts. Clinical and Experimental Allergy. 2007;37(7):1049-1054.
  59. Nigro E, Daniele A, Scudiero O, Ludovica MM, Roviezzo F, D'Agostino B, Mazzarella G, Bianco A. Adiponectin in Asthma: Implications for Phenotyping. Curr Protein Pept Sci. 2015;16(3):182-187.
  60. Sideleva O, Suratt BT, Black KE, Tharp WG, Pratley RE, Forgione P, Dienz O, Irvin CG, Dixon AE. Obesity and asthma:an inflammatory disease of adipose tissue not the airway. American Journal of Respiratory and Critical Care Medicine. 2012;186(7):598-605. doi:10.1164/rccm.201203-0573OC
  61. Weng M, Raher MJ, Leyton P, Combs TP, Scherer PE, Bloch KD, Medoff BD. Adiponectin decreases pulmonary arterial remodeling in murine models of pulmonary hypertension. American Journal of Respiratory Cell and Molecular Biology. 2011;45(2):340-347.
  62. Ionescu LI, Alphonse RS, Arizmendi N, Morgan B, Abel M, Eaton F, Duszyk M, Vliagoftis H, Aprahamian TR, Walsh K, Thébaud B. Airway delivery of soluble factors from plastic-adherent bone marrow cells prevents murine asthma. American Journal of Respiratory Cell and Molecular Biology. 2012;46(2):207-216.
  63. Sood A, Qualls C, Schuyler M, Thyagarajan B, Steffes MW, Smith LJ, Jacobs DR Jr. Low serum adiponectin predicts future risk for asthma in women. American Journal of Respiratory and Critical Care Medicine. 2012;186(1):41-47. doi:10.1164/rccm.201110-1767OC
  64. Mineev VN, Lalaeva TM, Vasil'eva TS i soavt. Phenotype of bronchial asthma with obesity. Pul'monologiya. 2012;2:102-107.
  65. Fallo F, Scarda A, Sonino N, Paoletta A, Boscaro M, Pagano C, Federspil G, Vettor R. Effect of glucocorticoids on adiponectin: a study in healthy subjects and in Cushing´s syndrome. Eur J Endocrinol. 2004;150:339-344.
  66. Kobayashi H, Ouchi N, Kihara S, Walsh K, Kumada M, Abe Y, Funahashi T, Matsuzawa Y. Selective suppression of endothelial cell apoptosis by the high molecular weight form of adiponectin. Circ Res. 2004;94:e27-e31.
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.