The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Tikhonova E.O.

V.I. Razumovsky Saratov State Medical University, Ministry of Health of Russia, Saratov, Russia

Liapina E.P.

Saratovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. V.I. Razumovskogo Minzdrava Rossii

Shuldyakov A.A.

Razumovsky Saratov State Medical University, Saratov, Russia

Satarova S.A.

V.I. Razumovsky Saratov State Medical University, Ministry of Health of Russia, Saratov, Russia

Use of succinate-containing agents in the treatment of infectious diseases

Authors:

Tikhonova E.O., Liapina E.P., Shuldyakov A.A., Satarova S.A.

More about the authors

Journal: Therapeutic Archive. 2016;88(11): 121‑127

DOI: 10.17116/terarkh20168811121-127

Read: 9437 times

Download PDF (RU)
Contact the author
Table of contents

USE OF SUCCINATE-CONTAINING AGENTS IN THE TREATMENT OF INFECTIOUS DISEASES
USE OF SUCCINATE-CONTAINING AGENTS IN THE TREATMENT OF INFECTIOUS DISEASES

To cite this article:

Tikhonova EO, Liapina EP, Shuldyakov AA, Satarova SA. Use of succinate-containing agents in the treatment of infectious diseases. Therapeutic Archive. 2016;88(11):121‑127. (In Russ.)
https://doi.org/10.17116/terarkh20168811121-127

МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Oxidative toxe­mia, hypo­xia and intra-abdominal hype­rtension in acute pancreatitis. Piro­gov Russian Journal of Surgery. 2024;(11):38-45
The role of drug Cyto­flavin in the correction of dysautonomia in patients with post-COVID syndrome. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(11):140-146
The effe­ctiveness of reha­bilitation measures using the drug Cortexin in children with neuropsychiatric pathology. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(12):86-92
High-throughput sequencing: a powe­rful tool for pathogen dete­ction and identification in clinical samples. Labo­ratory Service. 2024;(4):49-56
The level of hypo­xia-induced factor-1a and asso­ciated mole­cules in preeclampsia. Russian Bulletin of Obstetrician-Gynecologist. 2025;(1):5-10
Cognitive impairment after major surgical operations. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(4-2):74-80
Proinflammatory cyto­kines — as a marker of the effe­ctiveness of neuroprotection in children with peri­natal nervous system damage. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(6):62-66
Features of the clinical course of multiple scle­rosis as a factor in persistent disa­bility. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(7-2):39-44
Resu­lts of 4 years of therapy with divo­zilimab in patients with rela­psing multiple scle­rosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(7-2):51-59
Effect of perioperative fluid therapy on ischemia-reperfusion syndrome in elective percutaneous coro­nary inte­rventions. Russian Journal of Cardiology and Cardiovascular Surgery. 2025;(5):586-592
Abstract:

The review gives data that reveal the role of succinic acid in providing cells with energy and oxygen under hypoxic conditions. It presents the results of clinical and experimental studies to evaluate the efficacy of succinate-containing drugs in the combination therapy of infectious diseases. The spectrum of biological effects of these drugs, which is provided by the synergy of their active ingredients, is considered.

Keywords:

hypoxia
succinic acid
infectious diseases
succinate-containing drugs
enteric infections

Authors:

Tikhonova E.O.

V.I. Razumovsky Saratov State Medical University, Ministry of Health of Russia, Saratov, Russia

Liapina E.P.

Saratovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. V.I. Razumovskogo Minzdrava Rossii

Shuldyakov A.A.

Razumovsky Saratov State Medical University, Saratov, Russia

Satarova S.A.

V.I. Razumovsky Saratov State Medical University, Ministry of Health of Russia, Saratov, Russia

Close metadata

References:

  1. Luk'yanova L. Molecular mechanisms of a fabric hypoxia and adaptation of an organism. Fiziologicheskii zhurnal. 2003;49(3):17-35. (In Russ.)
  2. Mushkambarov N. Metabolizm: strukturno-khimicheskii i termodinamicheskii analiz. Moscow: Khimiya; 1983. (In Russ.)
  3. Sologub T, Romantsov M, Kremen' N, Aleksandrova L, Anikina O, Sukhanov D, Kovalenko A, Petrov A, Ledvanov M, Stukova N, Chesnokova N, Bizenkova M, Ponukalina E, Nevvazhai T. Svobodnoradikal'nye protsessy i vospalenie (patogeneticheskie, klinicheskie i terapevticheskie aspekty). Uchebnoe posobie dlya vrachei. Moscow: Akademiya Estestvoznaniya; 2008. (In Russ.)
  4. Bizenkova M, Romantsov M, Chesnokova N. Metabolic effects of antioxidants in acute anoxic hypoxia. Fundamental'nye issledovaniya. 2006;1:17-21. (In Russ.)
  5. Kondrashova M. Regulyatsiya yantarnoi kislotoi energeticheskogo obespecheniya i funktsional'nogo sostoyaniya tkani: Avtoref. dis. d-ra biol. Nauk. Pushchino; 1971. (In Russ.)
  6. Konovalova M. Yantarnaya kislota protiv vospalenii i opukholei. SPb.: Ves'; 2005. (In Russ.)
  7. Mazina N, Mazin P, Romantsov M. Pharmacoeconomic foundation of an application of reamberin upon urgent states. Fundamental'nye issledovaniya. 2012;7:116-122. (In Russ.)
  8. Yakovlev A. Reamberin v praktike infuzionnoi terapii kriticheskikh sostoyanii. Prakticheskie rekomendatsii. SPb.; 2008. (In Russ.)
  9. Kukhta V, Koganovich A, Morozkina T, Oletskii E. Osnovy biokhimii. Moscow: Meditsina; 1999. (In Russ.)
  10. He W, Miao FJ-P, Lin DC-H et al. Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors. Nature. 2004;429:188-193.
  11. Evglevskii A, Ryzhkova G, Evglevskaya E, Vanina N, Mikhailova I, Denisova A, Eryzhenskaya N. Biological role and metabolic activity of amber acid. Vestnik Kurskoi gosudarstvennoi sel'skokhozyaistvennoi akademii. 2013;9:67-69. (In Russ.)
  12. Okovityi S, Zaplutanov V, Smagina A, Sukhanov D. Antihypoxants in the modern clinical practice. Klinicheskaya meditsina. 2012;9:63-68. (In Russ.)
  13. Zagorska A, Dulak J. HIF-1: the knowns and unknowns of hypoxia sensing. Acta Biochimica Polonica. 2004;51(3):563-585.
  14. Misyurin A. Molecular pathogenesis of myeloproliferative diseases. Klinicheskaya onkogematologiya. 2009;2(3):211-219. (In Russ.)
  15. Nagle DG, Zhou Yu-Dong. Natural Product-Derived Small Molecule Activators of Hypoxia-Inducible Factor-1 (HIF-1). Curr Pharm Des. 2006;12(21):2673-2688. doi:10.2174/138161206777698783
  16. Novikov V, Levchenkova O. Recent trends of searching of pharmaceuticals with anti-hypoxemic activity and targets for their action. Eksperimental'naya i klinicheskaya farmakologiya. 2013;76(5):47. (In Russ.)
  17. Afanas'ev V. Klinicheskaya farmakologiya reamberina (ocherk): Posobie dlya vrachei. SPb.: Taktik-Studio; 2005. (In Russ.)
  18. Zaplutanov V, Kovalenko A, Sukhanov D. Reamberin: eksperimental'nye i klinicheskie issledovaniya. Referativnyi sbornik nauchnykh rabot, protsitirovannykh v PubMed (baza dannykh meditsinskikh i biologicheskikh publikatsii). Pod red. Okovitogo S. SPb.; 2012. (In Russ.)
  19. Reamberin v klinicheskoi praktike. Issledovaniya, provedennye v 2005—2007 godakh: Prakticheskoe rukovodstvo dlya vrachei ORIT. Pod red. Romantsova M, Kovalenko A. SPb.; 2007. (In Russ.)
  20. Romantsov M, Sologub T, Shul'dyakov A, Bizenkova M, Antonova T, Sukhanov D, Vasil'ev S, Smagina A, Kovalenko A. Approaches to treatment of damages of a liver in practice of the clinical physician (the clinical review). Fundamental'nye issledovaniya. 2011;9(chast' 3):488-495. (In Russ.)
  21. Sologub T, Goryacheva L, Sukhanov D. Hepatoprotective activity of a remaksol at chronic damages of a liver. Klinicheskaya meditsina. 2010;1:62-66. (In Russ.)
  22. Tikhonova E, Lyapina E, Shul'dyakov A. Studying of effectiveness of pathogenetic therapy of patients with acute intestinal infections with using a succinate containing medication Reamberin. Eksperimental'naya i klinicheskaya farmakologiya. 2013;76(1):11-13. (In Russ.)
  23. Shatokhina N. Vliyanie metabolicheskikh korrektorov (preparatov yantarnoi kisloty, natriya suktsinata i dikholina suktsinata) na techenie eksperimental'nykh allergicheskikh reaktsii: Avtoref. dis. kand. med. nauk. Staraya Kupavna; 2006. Ssylka aktivna na 08.03.2016. Dostupno po: http://medical-diss.com/medicina/vliyanie-metabolicheskih-korrektorov-preparatov-yantarnoy-kisloty-natriya-suktsinata-i-diholina-suktsinata-na-techenie-ek#ixzz42LeGNUuB (In Russ.)
  24. Shul'dyakov A, Blinnikova E, Soboleva L, Savinova G. Optimization of metabolic therapy of chronic viral hepatitises. Vestnik Sankt-Peterburgskoi gosudarstvennoi meditsinskoi akademii im. I.I. Mechnikova. 2009;1:156-159. (In Russ.)
  25. Sologub T, Goryacheva L, Sukhanov D, Romantsov M, Antonova T, Yakovlev A, Radchenko V, Shul'dyakov A, Rechnik V, Suzdal'tsev A, Esaulenko E, Maksimov S, Baranova I, Kovalenko A. Studying of a pharmacotherapeutic effectiveness, safety of inclusion of remaksol in therapy of chronic damages of a liver with an assessment of risk of failures. Vestnik Sankt-Peterburgskoi gosudarstvennoi meditsinskoi akademii im. I.I. Mechnikova. 2009;2:116-124. (In Russ.)
  26. Shul'dyakov A, Rechnik V, Soboleva L, Blinnikova E, Savinova G. Perfecting of pathogenetic therapy of chronic hepatitis C. Epidemiologiya i infektsionnye bolezni. 2009;3:18-21. (In Russ.)
  27. Romantsov M, Sukhanov D, Petrov A, Aleksandrova L, Sologub T, Kovalenko A, Savateeva-Lyubimova T, Emel'yanova O, Bizenkova M. Application of substrates of energy interchange at chronic damage of a liver for correction of metabolic violations (experimental clinical trials). Fundamental'nye issledovaniya. 2011;3:131-141. (In Russ.)
  28. Gorelov A. Lechenie ostrykh kishechnykh infektsii u detei: Posobie dlya vrachei. Moscow; 2003. (In Russ.)
  29. Zaplutanov V, Romantsov M, Tikhonova E, Al'myasheva R, Lyapina E, Pavelkina V, Shul'dyakov A. Particulars of a course of acute intestinal infections with an assessment of effectiveness of pathogenetic therapy. Antibiotiki i khimioterapiya. 2012;57(9-10):17-24. (In Russ.)
  30. Konnova Yu. Patogeneticheskie mekhanizmy intoksikatsionnogo sindroma pri ostrykh kishechnykh infektsiyakh i metody ego korrektsii: Avtoref. dis. kand. med. nauk. Moskva; 2007. Ssylka aktivna na 08.03.2016. Dostupno po: http://www.dissercat.com/content/patogeneticheskie-mekhanizmy-intoksikatsionnogo-sindroma-pri-ostrykh-kishechnykh-infektsiyak#ixzz42L13qCXy (In Russ.)
  31. Mikhailova E, Karal'skii S, Koshkin A, Chudakova T, Levin D. The effectiveness of a medication Reamberin in treatment of severe forms of acute intestinal infection in children. Eksperimental'naya i klinicheskaya farmakologiya. 2011;74(11):33-35. (In Russ.)
  32. Murtazina G. Kliniko-laboratornoe i eksperimental'noe obosnovanie primeneniya selimaktsida pri sal'monelleze i shigelleze: Avtoref. dis. kand. med. nauk. SPb.; 2004. Ssylka aktivna na 08.03.2016. Dostupno po: http://www.dissercat.com/content/kliniko-laboratornoe-i-eksperimentalnoe-obosnovanie-primeneniya-selimaktsida-pri-salmonellez (In Russ.)
  33. Ploskireva A, Gorelov A, Zhuchkova S i dr. Referativnyi sbornik nauchnykh rabot, protsitirovannykh v PubMed (baza dannykh meditsinskikh i biologicheskikh publikatsii) v 2012 godu. Pod red. Belova V. SPb.; 2013. (In Russ.)
  34. Tikhomirova O, Mikhailova E, Romantsov M, Govorova L. Correction of violations of antioxidative system in children with acute intestinal infections. Eksperimental'naya i klinicheskaya farmakologiya. 2010;9:28-33. (In Russ.)
  35. Chudakova T. Sindrom endogennoi intoksikatsii i gemoreologicheskie narusheniya pri rotavirusnoi infektsii u detei i metody ikh korrektsii: Avtoref. dis. kand. med. nauk. Saratov; 2007. Ssylka aktivna na 08.03.2016. Dostupno po: http://medical-diss.com/medicina/sindrom-endogennoy-intoksikatsii-i-gemoreologicheskie-narusheniya-pri-rotavirusnoy-infektsii-u-detey-i-metody-ih-korrekts (In Russ.)
  36. Skoromets A, Nikitina V, Baryshev B. Influence of a reamberin on a vascular-thrombocytic and plasma-coagulation hemostasis links in a blood plasma of donors in vitro. Vestnik Sankt-Peterburgskoi meditsinskoi akademii im. I.I. Mechnikova. 2003;4:132-136. (In Russ.)
  37. Okovityi S, Sukhanov D, Zaplutanov V i dr. Referativnyi sbornik nauchnykh rabot, protsitirovannykh v PubMed (baza dannykh meditsinskikh i biologicheskikh publikatsii) v 2012 godu. Pod red. Belova V. SPb.; 2013. (In Russ.)
  38. Markevich P, Danilenko S., Yankin A. The role of Studying of effectiveness of pathogenetic therapy of patients with acute intestinal infections with use a succinate containing Reamberin's preparation “Cytoflavin” in clinical practice. Byulleten' VSNTs SO RAMN. 2010;3(73):109. (In Russ.)
  39. Bizenkova M, Romantsov M, Afanas'eva G, Chesnokova N. Cytoflavin as the medication of effective correction of metabolic disorders upon hypoxia of different genesis. Uspekhi sovremennogo estestvoznaniya. 2006;4:28. (In Russ.)
  40. Fufaev E. Korrektsiya svobodno-radikal'nogo okisleniya u bol'nykh ostroi infektsionnoi destruktsiei legkikh: Avtoref. dis. kand. med. nauk. SPb.; 2006. Ssylka aktivna na 08.03.2016. Dostupno po: http://www.dissercat.com/content/korrektsiya-svobodnoradikalnogo-okisleniya-u-bolnykh-ostrymi-infektsionnymi-destruktsiyami-l (In Russ.)
  41. Zubareva S, Shul'dyakov A, Trubetskov A Lyapina E, Satarova S, Anashchenko A. Metabolic therapy of a chronic brucellosis as a mean of correction of an endotoxemia and the functional violations of a myocardium. Vestnik Sankt-Peterburgskoi gosudarstvennoi meditsinskoi akademii im. I.I. Mechnikova. 2008;3:93-95. (In Russ.)
  42. Zykova O. Klinicheskie osobennosti gepatita A pri vodnykh vspyshkakh i sporadicheskikh sluchayakh zabolevaniya i effektivnost' metabolicheskoi terapii: Avtoref. dis. kand. med. nauk. Saratov; 2007. Ssylka aktivna na 08.03.2016. Dostupno po: http://www.dissercat.com/content/klinicheskie-osobennosti-gepatita-pri-vodnykh-vspyshkakh-i-sporadicheskikh-sluchayakh-zabole (In Russ.)
  43. Aleksandrov P. Eksperimental'naya otsenka gepatotsitomoduliruyushchego effekta membranoprotektorov pri endotoksikoze: Avtoref. dis. kand. biol. nauk. Staraya Kupavna; 2007. Dostupno po: http://medical-diss.com/medicina/eksperimentalnaya-otsenka-gepatotsitomoduliruyuschego-effekta-membranoprotektorov-pri-endotoksikoze. Ssylka aktivna na 07.03.2016. (In Russ.)
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.