OBJECTIVE

To study the changes in indicators of oxidative toxemia, hypoxia and intra-abdominal hypertension in various forms of acute pancreatitis.

MATERIAL AND METHODS

The results of complex diagnostics in 62 patients with various forms of acute pancreatitis were analyzed. We estimated the indicators of oxidative status, hypoxia and intra-abdominal hypertension. Edematous pancreatitis was diagnosed in 35 (56.5%) patients, destructive acute pancreatitis — in 27 (43.5%) patients (sterile pancreatic necrosis in 14 (22.6%) patients, and infected pancreatic necrosis in 13 (20.9%) patients).

RESULTS

Progression of disease is followed by active lipid peroxidation with accumulation of conjugated dienes and malondialdehyde, as well as increase in serum lactate and pyruvate levels. Intra-abdominal pressure increases with progression of disease and destructive processes. There was direct correlation between intra-abdominal pressure and clinical form of acute pancreatitis (r=0.8033, p<0.001). The same was true for intra-abdominal pressure and indicators of oxidative toxemia (conjugated dienes — p<0.001, malondialdehyde — p<0.001) and hypoxia (lactate — p<0.001, pyruvate — p<0.001, and hypoxia coefficient — p<0.001).

CONCLUSION

A comprehensive examination of patients with acute pancreatitis allows to analyze lipid peroxidation, hypoxia and intra-abdominal hypertension. These parameters depend on clinical form of disease.