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Grigoryan D.A.
Center for Strategic Planning and Management of Medical and Biological Health Risks
Matsvay A.D.
Center for Strategic Planning and Management of Medical and Biological Health Risks
Chernitsov A.V.
Center for Strategic Planning and Management of Medical and Biological Health Risks
Shipulin G.A.
Center for Strategic Planning and Management of Medical and Biological Health Risks
High-throughput sequencing: a powerful tool for pathogen detection and identification in clinical samples
Journal: Laboratory Service. 2024;13(4): 49‑56
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To cite this article:
Grigoryan DA, Matsvay AD, Chernitsov AV, Shipulin GA. High-throughput sequencing: a powerful tool for pathogen detection and identification in clinical samples. Laboratory Service.
2024;13(4):49‑56. (In Russ.)
https://doi.org/10.17116/labs20241304149
Recent advancements in high-throughput sequencing have significantly expanded the possibilities for diagnosing and surveilling infectious diseases. This article offers a comprehensive examination of key sequencing methodologies, emphasizing their unique characteristics and potential applications in clinical practice. Both metagenomic and targeted approaches are assessed in terms of their effectiveness, limitations, and feasibility across various diagnostic fields. We also discuss current challenges in standardization and the analysis of large genomic datasets, highlighting the urgent need for innovative bioinformatics solutions to streamline these processes. The technologies explored in this article are already transforming strategies for diagnosing infectious diseases, and their continued development may play a crucial role in the evolution of clinical diagnostic systems.
Keywords:
Authors:
Grigoryan D.A.
Center for Strategic Planning and Management of Medical and Biological Health Risks
Matsvay A.D.
Center for Strategic Planning and Management of Medical and Biological Health Risks
Chernitsov A.V.
Center for Strategic Planning and Management of Medical and Biological Health Risks
Shipulin G.A.
Center for Strategic Planning and Management of Medical and Biological Health Risks
Received:
05.11.2024
Accepted:
08.11.2024
List of references:
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