Aging and pain: Specific features of neuropathy treatment in the elderly

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The changes in the somatosensory system in aging and peripheral neuropathies are similar. Higher pain sensitivity thresholds in the presence of axonopathy are accompanied by paradoxically decreased pain tolerance associated with neuroplastic changes in the spinal cord and brain. The symptomatic treatment of neuropathic pain syndrome with antidepressants, anticonvulsants, and opioids is related to the lower quality of life in elderly patients and to the high risk of severe side effects. The pathogenetic treatment of polyneuropathies frequently increases the intensity of neuropathic pain at its beginning; however, it can recover the function of an axon and reduce the degree of deficiency states. The paper discusses methods for increasing the safety of treatment for neuropathic pain in elderly patients, a relationship between the pathogenesis of nervous system aging and distal diabetic polyneuropathy, and ways of their correction.

Keywords:

aging

apoptosis

neuroplasticity

sensitization

neuropathic pain

symptomatic therapy for pain

pathogenetic treatment for neuropathies

anticholinesterase drugs

neuromidine

noofen

Authors:

Barinov A.N.

Sechenov First Moscow State Medical University, Moscow

Parkhomenko E.V.

Altai State Medical University, Barnaul

Makhinov K.A.

Sechenov First Moscow State Medical University, Moscow

List of references:

Hof P.R., Mobbs C.V. Fundamental Neurobiology of Aging. New York: Academic Press 2001.
Hughes K.A., Reynolds R.M. Evolutionary and mechanistic theories of aging. Ann Rev Entomol 2005; 55: 421-445.
Gagliese L., Farrell M.J. The neurobiology of aging, nociception and pain: An integration of animal and human experimental evidence. In: Gibson S.J., Weiner D.K. (eds). Pain in Older Persons. Seattle, WA: IASP Press 2005: 25-44.
Riley J.L. III, Wade J.B., Robinson M.E., Price D.D. The stages of pain processing across the adult lifespan. J Pain 2000; 1: 162-170.
Ochoa J., Mair W.G. The normal sural nerve in man. II. Changes in the axons and Schwann cells due to ageing. Acta Neuropathol 1969; 13: 217-239.
Gibson S.J., Farrell M. A review of age differences in the neurophysiology of nociception and the perceptual experience of pain. Clin J Pain 2004; 20: 227-239.
Iwata K., Tsuboi Y., Shima A. et al. Central neuronal changes after nerve injury: Neuroplastic influences of injury and aging. J Orofac Pain 2004; 18: 293-298.
Zimmerman M. Pathology of neuropathic pain. Eur J Pharmacol 2001; 429: 23-37.
Алексеев В.В., Баринов А.Н., Кукушкин М.Л. и др. Bol': rukovodstvo dlya vrachei i studentov. Pod red. N.N. Yakhno. M: MedPress 2009; 302.
Мурашко Н.К., Баринов А.Н., Яворский В.В. и др. Nevropaticheskaya bol' pri porazhenii perifericheskoi nervnoi sistemy: stratifikatsiya lecheniya. Med Sovet 2013 4; 54-62.
Яхно Н.Н., Строков И.А., Баринов А.Н. и др. Lechenie bolevogo sindroma pri distal'noi diabeticheskoi polinevropatii. Bol' 2005; 1: 8-15.
Pollack M., Leeuwenburgh C. Molecular mechanisms of oxidative stress in aging: Free radicals, aging, antioxidants and disease. In: Sen C.K., Packer L., Hanninen O. (eds). Handbook of Oxidants and Antioxidants in Exercise. New York: Elsevier 1999: 881-923.
Wang S., Albers K.M. Behavioral and cellular level changes in the aging somatosensory system. Ann N Y Acad Sci 2009; 1170: 745-749.
Novak J.C., Lovell J.A., Stuesse S.L. et al. Aging and neuropathic pain. Brain Res 1999; 833: 308-310.
Gagliese L. Pain and aging: The emergence of a new subfield of pain research. J Pain 2009; 10: 343-353.
Melzack R. From the gate to the neuromatrix. Pain 1999; 82 (Suppl. 1): S121-S126.
Novembre G., Zanon M., Silani G. Empathy for social exclusion involves the sensory-discriminative component of pain: a within-subject fMRI study. Soc Cogn Affect Neurosci 2014; 9 (9): doi:10.1093/scan/nsu038.
Emerson N., Zeidan F., Lobanov O. et al. Pain sensitivity is inversely related to regional grey matter density in the brain. Pain 2014; http://dx.doi.org/10.1016/j.pain.2013.12.004
Баринов А.Н. Lechenie boli v spine u pozhilykh patsientov Consilium Medicum 2013; 9: 102-109.
Новосадова М.В., Баринов А.Н. Vegetativnaya nevropatiya pri sakharnom diabete: klinicheskie proyavleniya, diagnostika i lechenie. Nevrol, neiropsikhiatr i psikhosom 2011; 2: 1-8.
Ewing D.J., Martin C.N., Young R.J., Clarke B.F. The value of cardiovascular autonomic function tests: 10 years experience in diabetes. Diabetes Care 1985; 8: 491-498.
Зиновьева О.Е., Строков И.А., Баринов А.Н. и др. Neiromidin v lechenii diabeticheskoi polinevropatii. Nevrol vestn 2007; 6: 52-55.
Дамулин И.В., Живолупов С.А., Зайцев О.С. и др. Neiromidin v klinicheskoi praktike. M: Meditsinskoe informatsionnoe agentstvo 2014; 56.
Баринов А.Н. Rol' okislitel'nogo stressa v zabolevaniyakh nervnoi sistemy - puti korrektsii. Trudnyi patsient 2012; 1: 6-10.
Аметов А.С., Баринов А.Н., Новосадова М.В. и др. Dolgovremennyi effekt posle 3-nedel'nogo kursa vnutrivennogo vvedeniya al'fa-lipoevoi kisloty pri diabeticheskoi polinevropatii s klinicheskimi proyavleniyami. Ter arkh 2010; 12: 61-64.
Dyck P.J., Ametov A.S., Barinov A.N. et al. The sensory symptoms of diabetic polyneuropathy are improved with a-lipoic acid. Diabetes Care 2003; 26: 770-776.
Ziegler D., Ametov A.S., Barinov A.N. et al. Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial. Diabetes Care 2007; 29: 2365-2370.
Elenkov I.J., Wilder R.L., Chrousos G.P. Vizi E.S. The sympathetic nerve - An integrative interface between two supersystems: The brain and the immune system. Pharmacol Rev 2000; 52: 595-638.
Seals D.R., Esler M.D. Human ageing and the sympathoadrenal system. J Physiol 2000; 528: 407-417.

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