Aging and pain: Specific features of neuropathy treatment in the elderly

Barinov A.N.; Parkhomenko E.V.; Makhinov K.A.

doi:https://doi.org/10.17116/terarkh20148612135-141

Barinov A.N.

Sechenov First Moscow State Medical University, Moscow

Parkhomenko E.V.

Altai State Medical University, Barnaul

Makhinov K.A.

Sechenov First Moscow State Medical University, Moscow

Aging and pain: Specific features of neuropathy treatment in the elderly

Authors:

Barinov A.N., Parkhomenko E.V., Makhinov K.A.

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Journal: Therapeutic Archive. 2014;86(12): 135‑141

DOI: 10.17116/terarkh20148612135-141

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Barinov AN, Parkhomenko EV, Makhinov KA. Aging and pain: Specific features of neuropathy treatment in the elderly. Therapeutic Archive. 2014;86(12):135‑141. (In Russ.)
https://doi.org/10.17116/terarkh20148612135-141

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Abstract:

The changes in the somatosensory system in aging and peripheral neuropathies are similar. Higher pain sensitivity thresholds in the presence of axonopathy are accompanied by paradoxically decreased pain tolerance associated with neuroplastic changes in the spinal cord and brain. The symptomatic treatment of neuropathic pain syndrome with antidepressants, anticonvulsants, and opioids is related to the lower quality of life in elderly patients and to the high risk of severe side effects. The pathogenetic treatment of polyneuropathies frequently increases the intensity of neuropathic pain at its beginning; however, it can recover the function of an axon and reduce the degree of deficiency states. The paper discusses methods for increasing the safety of treatment for neuropathic pain in elderly patients, a relationship between the pathogenesis of nervous system aging and distal diabetic polyneuropathy, and ways of their correction.

Keywords:

aging

apoptosis

neuroplasticity

sensitization

neuropathic pain

symptomatic therapy for pain

pathogenetic treatment for neuropathies

anticholinesterase drugs

neuromidine

noofen

Authors:

Barinov A.N.

Sechenov First Moscow State Medical University, Moscow

Parkhomenko E.V.

Altai State Medical University, Barnaul

Makhinov K.A.

Sechenov First Moscow State Medical University, Moscow

Close metadata

References:

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