The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Koludarova E.M.

Russian Centre of Forensic Medical Expertise

Tuchik E.S.

Russian Centre of Forensic Medical Expertise;
Pirogov Russian National Research Medical University

Problems of forensic diagnosis of diffuse axonal brain injury in the acute post-traumatic period

Authors:

Koludarova E.M., Tuchik E.S.

More about the authors

Journal: Forensic Medical Expertise. 2022;65(2): 54‑58

DOI: 10.17116/sudmed20226502154

Views: 993

Downloaded: 39

Download PDF (RU)
Contact the author
Table of contents

PROBLEMS OF FORENSIC DIAGNOSIS OF DIFFUSE AXONAL BRAIN INJURY IN THE ACUTE POST-TRAUMATIC PERIOD
PROBLEMS OF FORENSIC DIAGNOSIS OF DIFFUSE AXONAL BRAIN INJURY IN THE ACUTE POST-TRAUMATIC PERIOD

To cite this article:

Koludarova EM, Tuchik ES. Problems of forensic diagnosis of diffuse axonal brain injury in the acute post-traumatic period. Forensic Medical Expertise. 2022;65(2):54‑58. (In Russ.)
https://doi.org/10.17116/sudmed20226502154

Подписка 2025-2 (Forensic Medical Expertise)
 
МСФ на ЯМ
Close metadata
Recommended articles:
Possibilities of using resu­lts of head computed tomo­graphy in victims with traumatic brain inju­ries. Fore­nsic Medi­cal Expe­rtise. 2024;(3):24-28
Main mechanisms of seco­ndary ischemic brain damage formation in case of craniocerebral injury. Fore­nsic Medi­cal Expe­rtise. 2024;(3):54-59
Dete­rmination of formation age of acute traumatic intracranial subdural hema­tomas using computed tomo­graphy. Fore­nsic Medi­cal Expe­rtise. 2025;(1):17-21
On the challenges and shortfalls of expert asse­ssment of maxi­llofacial inju­ries with concussions acco­rding to medi­cal docu­ments only. Fore­nsic Medi­cal Expe­rtise. 2025;(1):54-58
Neuromodulatory pharmacotherapy indi­vidualization in prolonged and chro­nic consciousness diso­rders after severe traumatic brain injury. Burdenko's Journal of Neurosurgery. 2024;(3):74-80
Brain injury following child maltreatment syndrome in newborns and young children. Shaken baby syndrome. Burdenko's Journal of Neurosurgery. 2024;(4):5-12
Severe traumatic brain injury with damage to the posterior cranial fossa in a teenager. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(8):113-117
Growing skull fracture of the orbi­tal roof: case report and lite­rature review. Burdenko's Journal of Neurosurgery. 2024;(5):77-86
Glial fibrillary acidic protein: is there a rela­tionship with the course of multiple scle­rosis and traumatic brain injury before the onset of multiple scle­rosis?. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(10):80-84

The article refers to actual problems of forensic diagnostics of diffuse axonal brain injury in the acute post-traumatic period, that is of particular importance in the case of head trauma in conditions of non-evidence. To solve the existing problems, it is necessary to conduct a comprehensive study aimed at improving the diffuse axonal brain injury examination by developing a unified methodological approach to running the forensic medical diagnostics of this form of traumatic brain injury and determining the duration of the acute (up to three days) post-traumatic period.

Keywords:

traumatic brain injury
diffuse axonal injury
acute post-traumatic period
forensic diagnosis
actual problems

Authors:

Koludarova E.M.

Russian Centre of Forensic Medical Expertise

Tuchik E.S.

Russian Centre of Forensic Medical Expertise;
Pirogov Russian National Research Medical University

Received:

31.03.2021

Accepted:

28.04.2021

List of references:

  1. Holbourn A. Mechanics of head injuries. Lancet. 1943;2:438-441. 
  2. Romodanovskiy PO, Belyaeva EV. Sudebno-meditsinskaya otsenka mekhanizma diffuznogo aksonal’nogo povrezhdeniya mozga pri travme golovy. Sovremennye voprosy sudebnoy meditsiny i ekspertnoy praktiki: Sbornik nauchnykh rabot. Izhevsk: Ekspertiza; 1998. (In Russ.).
  3. Adams JH, Gracham DI, Gennarelli TA. Head injury in man and experimental animals: neuropathology. Acta Neurochirurgica. 1983;32:15-30.  https://doi.org/10.1007/978-3-7091-4147-2_2
  4. Gennarelli TA, Meaney DF. Mechanisms of primary head injury. In: Wilkins RH, Rengachary SS. Neurosurgery. New York: McGraw-Hill; 1996.
  5. Romodanovskiy PO. Kompleksnaya sudebno-meditsinskaya diagnostika i ekspertnaya otsenka povrezhdeniy golovnogo mozga pri travme golovy: Dis. ... d-ra med. nauk. M. 1996. (In Russ.).
  6. Lebedev VV, Krylov VV. Rukovodstvo po neotlozhnoy neyrohirurgii. M.: Meditsina; 2000. (In Russ.).
  7. Kim JJ, Gean AD. Imaging for the diagnosis and management of traumatic brain injury. Neurotherapeutics. 2011;8:39-53.  https://doi.org/10.1007/s13311-010-0003-3
  8. Popov VL. Cherepno-mozgovaya travma: Sudebno-meditsinskie aspekty. L.: Meditsina; 1988. (In Russ.).
  9. Sahuquillo-Barris J, Lamarca-Ciuro J, Vilaita-Castan J, Rubio-Garcia E, Rodriguez-Pazos M. Acute subdural hematoma and diffuse axonal injury after severe head trauma. J Neurosurgery. 1988;68:894-900.  https://doi.org/10.3171/jns.1988.68.6.0894
  10. Pashinyan GA, Kasumova SYu, Dobrovol’skiy GF, Romodanovskiy PO. Patomorfologiya i ekspertnaya ocenka povrezhdeniy golovnogo mozga pri cherepno-mozgovoy travme. M.—Izhevsk: Ekspertiza; 1994. (In Russ.).
  11. Kasumova SYu. Patologicheskaya anatomiya cherepno-mozgovoy travmy. In: Konovalov AN, Lihterman LB, Potapov AA. Klinicheskoe rukovodstvo po cherepno-mozgovoy travme. T. I. M.: Antidor; 1998. (In Russ.).
  12. Adams JH, Doyle D, Ford I, Gennarelli TA, Graham DI, Mclellan DR. Diffuse axonal injury in head injury: definition, diagnosis and grading. Histopathology. 1989;15:49-59.  https://doi.org/10.1111/j.1365-2559.1989.tb03040.x
  13. Maxwell WL, Graham DI. Loss of axonal microtubules and neurofilaments after stretch-injury to guinea pig optic nerve fibers. J Neurotrauma. 1997;14:603-614.  https://doi.org/10.1089/neu.1997.14.603
  14. Pettus EH, Christman CW, Giebel ML, Povlishock JT. Traumatically induced altered membrane permeability: its relationship to traumatically induced reactive axonal change. J Neurotrauma. 1994;11(5):507-522.  https://doi.org/10.1089/neu.1994.11.507
  15. Iwata A, Stys PK, Wolf JA, Chen XH, Taylor AG, Meaney DF, Smith DH. Traumatic axonal injury induces proteolytic cleavage of the voltage-gated sodium channels modulated by tetrodotoxin and protease inhibitors. Neuroscience. 2004;24:4605-4613. https://doi.org/10.1523/JNEUROSCI.0515-03.2004
  16. Povlishock JT. Pathobiology of traumatically induced axonal injury in animals and man. Ann Emergency Medicine. 1993;22(6):980-986.  https://doi.org/10.1016/s0196-0644(05)82738-6
  17. Christman CW, Grady MS, Walker SA, Holloway KL, Povlishock JT. Ultrastructural studies of diffuse axonal injury in humans. J Neurotrauma. 1994;11(2):173-186.  https://doi.org/10.1089/neu.1994.11.173
  18. Siedler DG, Chuah MI, Kirkcaldie MT, Vickers JC, King AE. Diffuse axonal injury in brain trauma: insights from alterations in neurofilaments. Frontiers in Cellular Neuroscience. 2014;8:429.  https://doi.org/10.3389/fncel.2014.00429
  19. Staal JA, Dickson TC, Chung RS, Vickers JC. Disruption of the ubiquitin proteasome system following axonal stretch injury accelerates progression to secondary axotomy. J Neurotrauma. 2009;26:781-788.  https://doi.org/10.1089/neu.2008.0669
  20. Maxwell WL. Development of concepts in the pathology of traumatic axon and traumatic brain injury. In: Kobeissy F.H. Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects. Boca Raton (FL):CRC Press/Taylor and Francis Group. 2015.
  21. Tang-Schomer MD, Johnson VE, Baas PW, Stewart W, Smith DH. Partial interruption of axonal transport due to microtubule breakage accounts for the formation of periodic varicosities after traumatic axonal injury. Exp Neurology. 2012;233(1):364-372.  https://doi.org/10.1016/j.expneurol.2011.10.030
  22. Hanell A, Greer JE, McGinn MJ, Povlishock JT. Traumatic brain injury-induced axonal phenotypes react differently to treatment. Acta Neuropathology. 2015;129:317-332.  https://doi.org/10.1007/s00401-014-1376-x
  23. Hill CS, Coleman MP, Menon DK. Traumatic axonal injury: mechanisms and translational opportunities. Trends in Neurosciences. 2016;39:311-324.  https://doi.org/10.1016/j.tins.2016.03.002
  24. Kovalev AV, Kvacheva YuE, Zavalishina LE, Shigeev SV, Fedulova MV, Shaj AN. Sudebno-meditsinskaya otsenka β-APP belka — markera aksonal’nykh povrezhdeniy golovnogo mozga pri smerti ot cherepno-mozgovoy travmy gistologicheskimi i immunogistohimicheskimi metodami: Metodicheskie rekomendatsii. M. 2018. (In Russ.).
  25. Davceva N, Janevska V, Ilievski B, Spasevska L, Popeska Z. Dilemmas concerning the diffuse axonal injury as a clinicopathological entity in forensic medical practice. J Forensic and Legal Medicine. 2012;19:413-418.  https://doi.org/10.1016/j.jflm.2012.04.011
  26. Blumbergs PC, Scott G, Manavis J, Wainwright H, Simpson DA, Mclean AJ. Staining of amyloid precursor protein to study axonal damage in mild head injury. Lancet. 1994;344:1055-1056. https://doi.org/10.1016/s0140-6736(94)91712-4
  27. DiLeonardi AM, Huh JW, Raghupathi R. Impaired axonal transport and neurofilament compaction occur in separate populations of injured axons following diffuse brain injury in the immature rat. Brain Res. 2009;1263:174-182.  https://doi.org/10.1016/j.brainres.2009.01.021
  28. Graham DI, Smith C, Reichard R, Leclercq PD, Gentleman SM. Trials and tribulations of using beta-amyloid precursor protein immunohistochemistry to evaluate traumatic brain injury in adults. Forensic Science International. 2004;146:89-96.  https://doi.org/10.1016/S0379-0738(03)00274-3
  29. Koludarova EM, Tuchik ES, Zorikov OV. Aksotomiya v posmertnoy diagnostike diffuznogo aksonal’nogo povrezhdeniya mozga. Sudebno-meditsinskaya ekspertiza. 2021;2:14-17. (In Russ.). https://doi.org/10.17116/sudmed20216402114
  30. Cummings PM, Trelka DP, Springer KM. Atlas Forensic Histopathology. USA: Cambridge University Press; 2011.
  31. Ng HK, Mahaliyana RD, Poon WS. The pathological spectrum of the diffuse axonal injury in blunt head trauma: assessment with axon and myelin stains. Clin Neurol Neurosurg. 1994;96:24-31.  https://doi.org/10.1016/0303-8467(94)90025-6
  32. Kovalev AV, Kvacheva YuE, Shaj AN. Algoritmy diagnostiki diffuznogo aksonal’nogo povrezhdeniya. Sbornik trudov VIII Vserossijskogo s»ezda sudebnykh medikov s mezhdunarodnym uchastiem. T. 1. M. 2019. (In Russ).
  33. Oppenheimer DR. Microscopic lesions in the brain following head injury. Journal of Neurology, Neurosur and Psychiatry. 1968;31:299-306.  https://doi.org/10.1136/jnnp.31.4.299
  34. Potapov AA, Lihterman LB, Kasumova SYu, Chabulov A, Gajtur EI. Diffuznye povrezhdeniya golovnogo mozga. V kn.: Klinicheskoe rukovodstvo po cherepno-mozgovoy travme. T. 1. M.: Antidor; 2001. (In Russ.).
  35. Gromov AP. Biomekhanika travmy (povrezhdeniya golovy, pozvonochnika i grudnoj kletki). M.: Meditsina; 1979. (In Russ.).
  36. Boyagina OD. Sovremennye predstavleniya o mozolistom tele kak o sisteme novogo plashcha. Aktual’nye problemy sovremennoy meditsiny. Vestnik ukrainskoy stomatologicheskoy akademii. 2015;15:293-299. (In Russ.).
  37. Clark JM. Distribution of microglial clusters in the brain after head injury. J Neurol, Neurosurg, Psychiat. 1974;37:463-474.  https://doi.org/10.1136/jnnp.37.4.463
  38. Hostiuc S, Pirici D, Negoi I, Ion DA, Ceausu M. Detection of diffuse axonal injury in forensic pathology. Romanian J Legal Medicine. 2014;22:145-152.  https://doi.org/10.4323/rjlm.2014.145
  39. Lebedev VV, Volkov PV. Diffuse axonal injury. Nejrohirurgiya. 2005;3:10-15. (In Russ.).
  40. Sherriff FE, Bridges LR, Gentleman SM, Sivaloganathan S, Wilson S. Markers of axonal injury in post mortem human brain. Acta Neuropathologica. 1994;88:433-439.  https://doi.org/10.1007/BF00389495
  41. Lin Y, Wen L. Inflammatory response following diffuse axonal injury. Int J Med Sciences. 2013;10:515-521.  https://doi.org/10.7150/ijms.5423
  42. Amor S, Puentes F, Baker D, Valk P. Inflammation in neurodegenerative diseases. Immunology. 2010;129:154-169.  https://doi.org/10.1111/j.1365-2567.2009.03225.x
  43. Agoston DV, Vink R, Helmy A, Risling M, Nelson D, Prins M. How to translate time: the temporal aspects of rodent and human pathobiological processes in traumatic brain injury. J Neurotrauma. 2019;36:1724-1737. https://doi.org/10.1089/neu.2018.6261
  44. Popov VL. Metodologicheskie osnovy sudebnoy meditsiny. SPb.: Yuridicheskiy centr; 2020. (In Russ.).

Close metadata

Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.