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Shmarov L.A.

FGBU "Rossiĭskiĭ tsentr sudebno-meditsinskoĭ kspertizy" Minzdrava Rossii, Moskva, Rossiia, 125284

Kochoyan A.L.

Department of Forensic Medical Investigations, FSBU Russian Center for Forensic Medical Investigations, Ministry of Health of Russia, Moscow, Russia, 125284

Stragis V.B.

Federal state budgetary institution «Russian Centre of Forensic Medical Expertise», Russian Ministry of Health, Moscow, Russia, 125284

Fedulova M.V.

FBGU"Rossiĭskiĭ tsentr sudebno-meditsinskoĭ ékspertizy" Minzdravsotsrazvitiia Rossii

Shai A.N.

Federal state budgetary institution «Russian Centre of Forensic Medical Expertise», Russian Ministry of Health, Moscow, Russia, 125284

Application of immunohistochemical study for the verification of diffuse axonal injury and determination of cause-and-effect relationships

Authors:

Shmarov L.A., Kochoyan A.L., Stragis V.B., Fedulova M.V., Shai A.N.

More about the authors

Journal: Forensic Medical Expertise. 2020;63(1): 53‑55

DOI: 10.17116/sudmed20206301153

Read: 1836 times

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Table of contents

APPLICATION OF IMMUNOHISTOCHEMICAL STUDY FOR THE VERIFICATION OF DIFFUSE AXONAL INJURY AND DETERMINATION OF CAUSE-AND-EFFECT RELATIONSHIPS
APPLICATION OF IMMUNOHISTOCHEMICAL STUDY FOR THE VERIFICATION OF DIFFUSE AXONAL INJURY AND DETERMINATION OF CAUSE-AND-EFFECT RELATIONSHIPS

To cite this article:

Shmarov LA, Kochoyan AL, Stragis VB, Fedulova MV, Shai AN. Application of immunohistochemical study for the verification of diffuse axonal injury and determination of cause-and-effect relationships. Forensic Medical Expertise. 2020;63(1):53‑55. (In Russ.)
https://doi.org/10.17116/sudmed20206301153

Подписка 2026 Судебно-медицинская экспертиза (Forensic Medical Expertise)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Aim of this study is to establish a possibility of finding morphologic signs of diffuse axonal injury early after the injury. Use of immunohistochemical examination of the brain to detect protein β-APP made it possible not only to diagnose this condition correctly, but also to reasonably and categorically answer the question of a causal relationship between causing damage and the onset of death.

Keywords:

traumatic brain injury
diffuse axonal injury
β-APP protein
causal relationship

Authors:

Shmarov L.A.

FGBU "Rossiĭskiĭ tsentr sudebno-meditsinskoĭ kspertizy" Minzdrava Rossii, Moskva, Rossiia, 125284

Kochoyan A.L.

Department of Forensic Medical Investigations, FSBU Russian Center for Forensic Medical Investigations, Ministry of Health of Russia, Moscow, Russia, 125284

Stragis V.B.

Federal state budgetary institution «Russian Centre of Forensic Medical Expertise», Russian Ministry of Health, Moscow, Russia, 125284

Fedulova M.V.

FBGU"Rossiĭskiĭ tsentr sudebno-meditsinskoĭ ékspertizy" Minzdravsotsrazvitiia Rossii

Shai A.N.

Federal state budgetary institution «Russian Centre of Forensic Medical Expertise», Russian Ministry of Health, Moscow, Russia, 125284

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References:

  1. Romodanovsky PO. Certain aspect of diffuse axonal injury to the brain in the case of head trauma. Sudebno-medicinskaja ekspertiza. 2013;3(56):18-20. (In Russ.)
  2. Matsko DE. Neirokhirurgicheskaya patologiya. Rukovodstvo. SPb: FGBU «RNKHI im. prof. A.L. Polenova» MZ Rossii, 2015. (In Russ.)
  3. Johnson MW, Stoll L, Rubio A, Troncoso J, Pletnikova O, Fowler DR, Li L. Axonal Injury in Young Pediatric Head Trauma: A Comparison Study of β-amyloid Precursor Protein (β-APP) Immunohistochemical Staining in Traumatic and Nontraumatic Deaths. J. Forensic Sci. 2011; 56(5):1198-1205. https://doi.org/10.1111/j.1556-4029.2011.01814.x
  4. Shai AN, Fedulova MV, Kvacheva YuE, Shigeev SV, Kovalev AV. The importance of marker proteins of the nervous tissue for morphological diagnostics of the craniocerebral injury. Sudebno-medicinskaja ekspertiza. 2017;4(60):40-45. (In Russ.) https://doi.org/10.17116/sudmed201760440-45
  5. Shay AN, Fedulova MV, Zavalishina LE, Kvacheva YuE, Shigeev SV, Kovalev AV. The detection of the biomolecular markers of the axonal damage resulting from the craniocerebral injury by the immunohistological methods. Sudebno-medicinskaja ekspertiza. 2018;3(61):8-10. (In Russ.) https://doi.org/10.17116/sudmed20186138-10
  6. Ogata M. Early diagnosis of diffuse brain damage resulting from a blunt head injury. Leg Med (Tokyo). 2007; 9:105-108. https://doi.org/10.1016/j.legalmed.2006.11.013
  7. Hortobágyi T, Wise S, Hunt N, Cary N, Djurovic V, Fegan-Earl A, Shorrock K, Rouse D, Al-Sarraj S. Traumatic axonal damage in the brain can be detected using beta-APP immunohistochemestri within 35 min after head injury to human adults. Neuropathol Appl Neurobiol. 2007;33(2):226-237. https://doi.org/10.1111/j.1365-2990.2006.00794.x
  8. Kovalev AV, Kvacheva YuE, Zavalishina LE, Shigeev SV, Fedulova MV, Shaj AN. Sudebno-medicinskaya otsenka β-APP belka — markera aksonal’nogo povrezhdeniya golovnogo mozga pri smerti ot cherepno-mozgovoj travmy gistologicheskimi i immunogistokhimicheskimi metodami. Metodicheskie rekomendatsii. M.: FGBU «RCSME» Minzdrava Rossii, 2018. (In Russ.)
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