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Bogomolov D.V.

Federal state budgetary institution «Russian Centre of Forensic Medical Expertise», Moscow, Russia

Fedulova M.V.

FBGU"Rossiĭskiĭ tsentr sudebno-meditsinskoĭ ékspertizy" Minzdravsotsrazvitiia Rossii

Shai A.N.

Federal state budgetary institution «Russian Centre of Forensic Medical Expertise», Russian Ministry of Health, Moscow, Russia, 125284

Pavlova A.Z.

FGBU "Rossiĭskiĭ tsentr sudebno-meditsinskoĭ ékspertizy" Minzdrava Rossii, Moskva

Zbrueva Yu.V.

Astrakhanskaia gosudarstvennaia meditsinskaia akademiia Minzdravsotsrazvitiia Rossii

The role of the immunohistochemical investigations in the documentation of intravitality and severity of the gunshot injuries to the soft tissues

Authors:

Bogomolov D.V., Fedulova M.V., Shai A.N., Pavlova A.Z., Zbrueva Yu.V.

More about the authors

Journal: Forensic Medical Expertise. 2018;61(6): 46‑47

DOI: 10.17116/sudmed20186106146

Read: 1184 times

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Table of contents

THE ROLE OF THE IMMUNOHISTOCHEMICAL INVESTIGATIONS IN THE DOCUMENTATION OF INTRAVITALITY AND SEVERITY OF THE GUNSHOT INJURIES TO THE SOFT TISSUES
THE ROLE OF THE IMMUNOHISTOCHEMICAL INVESTIGATIONS IN THE DOCUMENTATION OF INTRAVITALITY AND SEVERITY OF THE GUNSHOT INJURIES TO THE SOFT TISSUES

To cite this article:

Bogomolov DV, Fedulova MV, Shai AN, Pavlova AZ, Zbrueva YuV. The role of the immunohistochemical investigations in the documentation of intravitality and severity of the gunshot injuries to the soft tissues. Forensic Medical Expertise. 2018;61(6):46‑47. (In Russ.)
https://doi.org/10.17116/sudmed20186106146

Подписка 2026 Судебно-медицинская экспертиза (Forensic Medical Expertise)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The objective of the present study was to determine intravitality and severity of a gunshot-inflicted trauma making use of the immunohistochemical (IGH) methods for the evaluation of the injury to the soft tissues of the wound canal. The immunohistochemical methods were employed to estimate the expression of fibrinogen and vimentin. The positive immunohistochemical reaction was obtained in the fibrinogen assay whereas the reaction in the zone of necrosis was negative. These findings give evidence of the thermal impact produced by the firearm projectile on the soft tissues. Deformation of the cytoskeleton registered in the IGH test for vimentin suggests its disintegration and therefore the severity of the injury. It is concluded that the investigations with the use of the immunohistochemical methods, make it possible to identify the affected parts of the wound canal.

Keywords:

immunohistochemical methods
gunshot-inflicted injuries
fibrinogen
vimentin

Authors:

Bogomolov D.V.

Federal state budgetary institution «Russian Centre of Forensic Medical Expertise», Moscow, Russia

Fedulova M.V.

FBGU"Rossiĭskiĭ tsentr sudebno-meditsinskoĭ ékspertizy" Minzdravsotsrazvitiia Rossii

Shai A.N.

Federal state budgetary institution «Russian Centre of Forensic Medical Expertise», Russian Ministry of Health, Moscow, Russia, 125284

Pavlova A.Z.

FGBU "Rossiĭskiĭ tsentr sudebno-meditsinskoĭ ékspertizy" Minzdrava Rossii, Moskva

Zbrueva Yu.V.

Astrakhanskaia gosudarstvennaia meditsinskaia akademiia Minzdravsotsrazvitiia Rossii

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References:

  1. Gyul’mamedova ND, Makarov IYu. Aktual’nye problem ustanovleniya ognestrel’nogo proiskhozhdeniya travmy i puti ih minimalizatsii. Sudebnaya meditsina: voprosy, problemy, expertnaya praktika. Materialy konferentsii. M. 2017. (In Russ.)
  2. Korzhevskij DE. Teoreticheskie osnovy i prakticheskoe primenenie metodov immunogistohimii: rukovodstvo. SPb.: SpetsLit, 2012. (In Russ.)
  3. Medzhidov MN, Bogomolov DV. Dannye immunogistohimicheskogo issledovaniya zazhivleniya experimental’nykh ran desny kak kriterij ustanovleniya davnosti povrezhdeniya slizistoj obolochki polosti rta. Nauchno-prakticheskaya konferentsiya, posvyashchennaya 200-letiyu sistematicheskogo prepodavaniya sudebnoj meditsiny v MMA im. I.M. Sechenova. Materialy. M. 2004. (In Russ.)
  4. Bavykin DV, Bahmet’ev VI. Markers of cell proliferation Ki-67 and anti-apoptosis bcl-2 in gunshot injuries. Prikladnye informatsionnye aspekty meditsiny. 2016;19(3):144-150. (In Russ.)
  5. Semenov GG, Bogomolova IN, Baranova MYa, Bogomolov DV. Opportunities of medicolegal diagnostics life-time constriction mark by morphological methods. Problemy expertizy v meditsine. 2007;7(3):47-51. ( In Russ.)
  6. Bogomolov DV, Zbrueva YuV, Putincev VA, Denisova OP. Forensic medical diagnostics of intravitality of the strangulation mark by morphological methods. Sudebno-meditsinskaya expertiza. 2016;59(2):40-44. (In Russ.) https://doi.org/10.17116/sudmed201659240-44
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