The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Rabinovich O.F.

Otdelenie patologii slizistoĭ obolochki rta FGBU TsNIIS i ChLKh Minzdrava Rossii, Moskva

Rabinovich I.M.

Otdelenie patologii slizistoĭ obolochki rta FGBU TsNIIS i ChLKh Minzdrava Rossii, Moskva

Abramova E.S.

Otdelenie zabolevaniĭ slizistoĭ obolochki rta TsNIIS i ChLKh, Moskva

The role of cytokines and immunoglobulins of the oral fluid in the genesis of autoimmune diseases of the oral mucosa

Authors:

Rabinovich O.F., Rabinovich I.M., Abramova E.S.

More about the authors

Journal: Stomatology. 2019;98(6‑2): 42‑45

Read: 7285 times


To cite this article:

Rabinovich OF, Rabinovich IM, Abramova ES. The role of cytokines and immunoglobulins of the oral fluid in the genesis of autoimmune diseases of the oral mucosa. Stomatology. 2019;98(6‑2):42‑45. (In Russ.)
https://doi.org/10.17116/stomat20199806242

Recommended articles:
Biomarkers in tear fluid in uveitis. Russian Annals of Ophthalmology. 2025;(4):88-95
Study of the role of inte­rleukin-1β in blood serum in patients with acne. Russian Journal of Clinical Dermatology and Vene­reology. 2025;(4):421-424
Modern stra­tegies for early diagnosis of cardiotoxicity caused by chemotherapy. Russian Journal of Preventive Medi­cine. 2025;(11):113-120
The fundamental foundations of periodontal aging. Part 3. Russian Journal of Operative Surgery and Clinical Anatomy. 2025;(4):68-74

References:

  1. Rabinovich OF, Rabinovich IM, Abramova ES. Epidemiology, etiology and pathogenesis of oral mucosa bullous lesions. Stomatologiya. 2019;98(2):71-75. (InRuss.). https://doi.org/10.17116/stomat20199802171
  2. Wiesner J, Vilcinskas A. Antimicrobial peptides. The ancient arm of the human immune system. Virulence. 2010;1:440-464.
  3. Rabinovich OF, Rabinovich IM, Abramova ES. Manifestations of dysbiosis and candidiasis in various diseases of the oral mucous membrane. Klinicheskaya stomatologiya. 2011;3:48-51. (In Russ.)
  4. Rhodus NL, Cheng B, Bowles W, Myers S, Miller L. Proinflammatory cytokine levels in saliva before and after treatment of (erosive) oral lichen planus with dexamethasone. Oral Dis. 2006;12:112-116.
  5. Makedonova YuA, Firsova IV, Poroiskaya AV, Marymova EB. Immunological indicators of oral fluid in patients with erosive and ulcerative forms of lichen planus in the oral cavity on the background of the combined treatment method. Volgogradskii nauchno-meditsinskii zhurnal. 2018;1:25-29. (In Russ.)
  6. Oskolsky GI, Zagorodnyaya EB, Lebedko OA, Obukhova GG, Berezina GP. The state of local cytokine status and its pathogenetic significance in lichen planus of the oral mucosa. Dal’nevostochnyi meditsinskii zhurnal. 2010; 4:86-89. (In Russ.)
  7. Makhneva NV, Molochkov VA, Beletskaya LV. Circulating autoantibodies and assessment of their role in the development of autoimmune pemphigus of paraneoplastic genesis. Vestnik dermatologii venerologii. 2009;2:47-53. (In Russ.)
  8. Saluja R, Kale A, Hal-likerimath S. Determination of levels of salivary IgA subclasses in patients with minor recurrent aphthous ulcer. J Oral Maxillofac Pathol. 2012;16:49-53.
  9. Rabinovich OF, Rabinovich IM, Abramova ES. Changes in the microbial flora in the pathology of the oral mucosa. Stomatologiya. 2011;6:71-76. (In Russ.)
  10. Rabinovich OF, Rabinovich IM, Abramova ES. Bactericidal activity of oral fluid in the complex diagnosis of dysbiotic changes of the oral mucosa. Stomatologiya. 2012;3:41-42. (In Russ.)
  11. Glazkova YuP, Tereshchenko AV, Korsunskaya IM. The role of abnormalities in cytokine status in lichen planus of the oral mucosa and red border of the lips. Sovremennye problemy dermatovenerologii, immunologii i vrachebnoi kosmetologii. 2010;6(6):38-41. (In Russ.)
  12. Letaeva OV. Clinical and immunological features of lichen planus. Vestnik Ural’skoi meditsinskoi akademicheskoi nauki. 2011;2:168-169. (In Russ.)
  13. Rhodus NL, Ho V, Miller CS, Myers S, Ondrey F. NF-kappaB dependent cytokine levels in saliva of patients with oral preneoplastic lesions and oral squamous cell carcinoma. Cancer Detect Prev. 2005;29:42-45.
  14. Aoyama Y, Nagai M, Kitajima Y. Binding of pemphigus vulgaris IgG to antigens in desmosome core domains excludes immune complexes rather than directly splitting desmosomes. Br J Dermatol. 2010;162(5):1049-1055.
  15. Zhang Y, Lin M, Zhang S, Wang Z, Jiang L, Shen J, Bai J, Gao F, Zhou M, Chen Q. NF-kappaB dependent cytokines in saliva and serum from patients with oral lichen planus: a study in an ethnic Chinese population. Cytokine. 2008;41:144-149. https://doi.org/10.1016/j.cyto.2007.11.004
  16. Matushevskaya EV, Lysenko AA, Svirishchevskaya EV. Clinical features and immune mechanisms of pathogenesis of true pemphigus. Sovremennye problemy dermatovenerologii, immunologii i vrachebnoi kosmetologii. 2008;1:18-26. (In Russ.)
  17. Khaitov RM. Physiology of the Immune System. Rossiiskii fiziologicheskii zhurnal im. I.M. Sechenova. 2000;86(3):252-267. (In Russ.)
  18. Liao W, Lin JX, Leonard WJ. IL-2 family cytokines: new insights into the complex roles of IL-2 as a broad regulator of T helper cell differentiation. Curr Opin Immunol. 2011;23(5):598-604. https://doi.org/10.1016/j.coi.2011.08.003
  19. Liu WZ, He MJ, Long L, Mu DL, Xu MS, Xue Xing,3 Xin Zeng,3 Ga Liao,3 Hong-Xia Dan, 3 and Qian-Ming Chen3. Interferon-γ and interleukin-4 detected in serum and saliva from patients with oral lichen planus. Int J Oral Sci. 2014;6:22-26. https://doi.org/10.1038/ijos.2013.74
  20. Bai J, Jiang L, Lin M, Zeng X, Wang Z, Chen Q. Association of polymorphisms in the tumor necrosis factor-alpha and Interleukin-10 genes with oral lichen planus: a study in a chinese cohort with Han ethnicity. J Interferon Cytokine Res. 2009;29(7):381-388. https://doi.org/10.1089/jir.2008.0089
  21. JuretiÄ M, CeroviÄ R, BeluÅiÄ-GobiÄ M, BrekaloPrÅo I, Kqiku L, Špalj S, Pezelj-Ribarić S. Salivary levels of TNF-α and IL-6 in patients with oral premalignant and malignant lesions. Folia Biol (Praha). 2013;59:99-102.
  22. Haiashi N, Kiclo J, Kedo R. Regulation of calprotectin expression by interleukin-1-alpha and transforming growth factor-beta in human gingival ceratinocytes. J Periodontal Res. 2007;42(1):1-7.
  23. Javor J, Chmurova N, Parnicka Z, Ferencik S, Grosse-Wilde H, Buc M, Svecova D. TNF-alpha and IL-10 gene polymorphisms show a weak association with pemphigus vulgaris in the Slovak population. Genes Immun. 2009;10(6):547-558. https://doi.org/10.1111/j.1468-3083.2009.03260.x
  24. Pezelj-Ribaric S, Prso IB, Abram M, Glazar I, Brumini G, Simunovic-Soskic M. Salivary levels of tumor necrosis factor-alpha in oral lichen planus. Mediators Inflamm. 2004;13:131-133. https://doi.org/10.1080/09629350410001688530
  25. Abdel-Haq A, Kusnierz-Cabala B, Darczuk D, Sobuta E, Dumnicka P, Wojas-Pelc A, Chomyszyn-Gajewska M. Interleukin-6 and neopterin levels in the serum and saliva of patients with Lichen Planus and oral Lichen Planus. J Oral Pathol Med. 2014;43:734-739. https://doi.org/10.10.1111/jop.12199.
  26. Gu GM, Martin MD, Darveau RP, Truelove E, Epstein J. Oral and serum IL-6 levels in oral lichen planus patients. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004;98:673-678.
  27. Venugopal SS, Murrell DF. Diagnosis and clinical features of pemphigus vulgaris. Immunol Allergy Clin North Ame. 2012;32(2):233-243.
  28. Malek TR, Castro I. Interleukin-2 receptor signaling: at the interface between tolerance and immunity. Immunity. 2010;33(2):153-165. https://doi.org/10.1016/j.immuni.2010.08.004
  29. Arenas-Ramirez, Natalia, Woytschak, Janine, Boyman, Onur. Interleukin-2: Biology, Design and Application. Trends Immunol. 2015;36(12):763-777. https://doi.org/10.1016/j.it.2015.10.003
  30. Abbas AK, Trotta E, Simeonov DR, Marson A, Jeffrey A. Bluestone Revisiting IL-2: Biology and therapeutic prospects. Scie Immunol. 2018;3:25. https://doi.org/10.1126/sciimmunol.aat1482

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.