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Ivina A.A.

Kafedra patologicheskoĭ anatomii meditsinskogo fakul'teta FGBOU VPO "Rossiĭskiĭ universitet druzhby narodov"

Syomkin V.A.

Otdelenie khirurgicheskoĭ stomatologii FGBU "Tsentral'nyĭ nauchno-issledovatel'skiĭ institut stomatologii i cheliustno-litsevoĭ khirurgii" Minzdrava RF, Moskva

Babichenko I.I.

Russian University of People’s Friendship, Moscow, Russia, 117198

Immunohistochemical criteria for differential diagnostics of squamous epithelium changes in pyogenic granuloma and squamous cell carcinoma of the oral mucosa

Authors:

Ivina A.A., Syomkin V.A., Babichenko I.I.

More about the authors

Journal: Stomatology. 2017;96(2): 33‑35

DOI: 10.17116/stomat201796233-35

Read: 1815 times

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Table of contents

IMMUNOHISTOCHEMICAL CRITERIA FOR DIFFERENTIAL DIAGNOSTICS OF SQUAMOUS EPITHELIUM CHANGES IN PYOGENIC GRANULOMA AND SQUAMOUS CELL CARCINOMA OF THE ORAL MUCOSA
IMMUNOHISTOCHEMICAL CRITERIA FOR DIFFERENTIAL DIAGNOSTICS OF SQUAMOUS EPITHELIUM CHANGES IN PYOGENIC GRANULOMA AND SQUAMOUS CELL CARCINOMA OF THE ORAL MUCOSA

To cite this article:

Ivina AA, Syomkin VA, Babichenko II. Immunohistochemical criteria for differential diagnostics of squamous epithelium changes in pyogenic granuloma and squamous cell carcinoma of the oral mucosa. Stomatology. 2017;96(2):33‑35. (In Russ.)
https://doi.org/10.17116/stomat201796233-35

Подписка 2026 Стоматология (Stomatology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The paper presents an example of differential diagnostic studies for pyogenic granuloma and oral squamous cell carcinoma (SCC). In the described case immunohistochemistry with antibodies to Ki-67 and Gli1 was used as conventional histological procedure proved to be inconvenient for adequate diagnostics. The immunohistochemical study established increased proliferative activity of epithelial cells specific both pyogenic granuloma and oral SCC, but intensive Gli1 protein expression in membranes and cytoplasm of epithelial cells with malignant transformation allowed differentiation of these neoplasms.

Keywords:

oral squamous cell carcinoma
pyogenic granuloma
immunohistochemistry

Authors:

Ivina A.A.

Kafedra patologicheskoĭ anatomii meditsinskogo fakul'teta FGBOU VPO "Rossiĭskiĭ universitet druzhby narodov"

Syomkin V.A.

Otdelenie khirurgicheskoĭ stomatologii FGBU "Tsentral'nyĭ nauchno-issledovatel'skiĭ institut stomatologii i cheliustno-litsevoĭ khirurgii" Minzdrava RF, Moskva

Babichenko I.I.

Russian University of People’s Friendship, Moscow, Russia, 117198

Close metadata

References:

  1. Keshava A, Gugwad S, Baad R, Patel R. Gingival squamous cell carcinoma mimicking as a desquamative lesion. J Indian Soc Periodontol. 2016;20:75-78. doi:10.4103/0972-124X.164765
  2. Siu A, Landon K, Ramos, D. Differential diagnosis and management of oral ulcers. Semin Cutan Med Surg. 2015;34:171-177. doi:10.12788/j.sder.2015.0170
  3. Koviazin VA, Grogor'ian AS, Katushkina AA, Babichenko II. Peculiarities of protein Ki-67 expression in cases of leukoplakia and epidermoid cancer of oral mucous membrane. Stomatologiia. 2010;89(6):4-6. (In Russ.).
  4. Gamayunov S.V., Shumskaya I.S. Bazal'nokletochnyi rak kozhi. Obzor sovremennogo sostoyaniya problemy. Prakticheskaya onkologiya. 2012;13:92-106. (In Russ.).
  5. Heffelfinger C, Ouyang Z, Engberg A et al. Correlation of Global MicroRNA Expression With Basal Cell Carcinoma Subtype. G3 (Bethesda). 2012;2(2):279-286. doi:10.1534/g3.111.001115
  6. Fan H-X et al. Sonic hedgehog signaling may promote invasion and metastasis of oral squamous cell carcinoma by activating MMP-9 and E-cadherin expression. Med. Oncol. 2014;31:41. doi:10.1007/s12032-014-0041-5
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