Modeling shifts and correlation of hematological and immunological parameters in chronic generalized periodontitis

Agarkov N.M.; Gontarev S.N.; Gontareva I.S.; Lutsenko V.D.; Yakovlev A.P.

doi:https://doi.org/10.17116/stomat201695612-16

Agarkov N.M.

South West State University, Kursk, Russia, Belgorod State National Research University, Belgorod, Russia

Gontarev S.N.

South West State University, Kursk, Russia, Belgorod State National Research University, Belgorod, Russia

Gontareva I.S.

South West State University, Kursk, Russia, Belgorod State National Research University, Belgorod, Russia

Lutsenko V.D.

Belgorodskiĭ gosudarstvennyĭ natsional'nyĭ issledovatel'skiĭ universitet;
Munitsipal'noe biudzhetnoe uchrezhdenie zdravookhraneniia "Gorodskaia bol'nitsa # 2 g. Belgoroda"

Yakovlev A.P.

South West State University, Kursk, Russia, Belgorod State National Research University, Belgorod, Russia

Modeling shifts and correlation of hematological and immunological parameters in chronic generalized periodontitis

Authors:

Agarkov N.M., Gontarev S.N., Gontareva I.S., Lutsenko V.D., Yakovlev A.P.

More about the authors

Journal: Stomatology. 2016;95(6): 12‑16

DOI: 10.17116/stomat201695612-16

Read: 861 times

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Agarkov NM, Gontarev SN, Gontareva IS, Lutsenko VD, Yakovlev AP. Modeling shifts and correlation of hematological and immunological parameters in chronic generalized periodontitis. Stomatology. 2016;95(6):12‑16. (In Russ.)
https://doi.org/10.17116/stomat201695612-16

Подписка 2026 Стоматология (Stomatology)

Использование инфографики авторами научных работ

Close metadata

Recommended articles:

The results of the examination of patients with chronic generalized periodontitis after novel coronavirus infection. Russian Journal of Stomatology. 2024;(4):18-22

Psoriasis in pregnant women. Russian Journal of Clinical Dermatology and Venereology. 2024;(5):517-524

The role of systemic and local immunity in the pathogenesis of endometriosis of varying degrees of prevalence of the process: a modern view. Russian Journal of Human Reproduction. 2024;(5):6-14

Immunology of the cervix in normal and pathological conditions (literature review). Russian Journal of Human Reproduction. 2024;(5):108-117

Immunomodulatory therapy in the postoperative period in chronic purulent otitis media. Russian Bulletin of Otorhinolaryngology. 2024;(6):10-17

Antifungal immunity in patients with chronic rhinosinusitis with nasal polyps. Russian Bulletin of Otorhinolaryngology. 2024;(6):40-45

Motor behavior in MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mice model of Parkinson’s disease treated with recombinant spidroin rS1/9 microgel. Molecular Genetics, Microbiology and Virology. 2024;(4):12-17

mRNA cancer vaccines: features of problems and collisions. Molecular Genetics, Microbiology and Virology. 2025;(1):3-16

Modeling and predicting chronic non-communicable diseases based on medical and social risk factors in older then working age people. Russian Journal of Preventive Medicine. 2025;(4):67-74

Anti-aging klotho protein. Associations with sleep patterns in obstructive sleep apnea: A pilot study. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(5-2):98-102

Abstract:

Simulation of shifts and correlations of hematological and immunological parameters of the T-cell immunity in 106 patients with chronic periodontal disease and 65 individuals of the control group allowed us to identify leading diagnostic parameters with the quantitative evaluation and enhanced contingency of intersystem communications in peripheral blood and cellular immunity. Mathematical modelling of systemic immunity revealed the most significant shift in absolute number of T-helpers and T-lymphocytes in peripheral blood. Less significant shifts were seen in relative numbers of T-helpers and T-suppressors as well as neutrophilic activity. The revealed changes may play an important role in both diagnosis and therapy of periodontal disease.

Keywords:

simulation

correlation

diagnostic parameters

immune system

chronic periodontal disease

Authors:

Agarkov N.M.

South West State University, Kursk, Russia, Belgorod State National Research University, Belgorod, Russia

Gontarev S.N.

South West State University, Kursk, Russia, Belgorod State National Research University, Belgorod, Russia

Gontareva I.S.

South West State University, Kursk, Russia, Belgorod State National Research University, Belgorod, Russia

Lutsenko V.D.

Belgorodskiĭ gosudarstvennyĭ natsional'nyĭ issledovatel'skiĭ universitet;
Munitsipal'noe biudzhetnoe uchrezhdenie zdravookhraneniia "Gorodskaia bol'nitsa # 2 g. Belgoroda"

Yakovlev A.P.

South West State University, Kursk, Russia, Belgorod State National Research University, Belgorod, Russia

Close metadata

References:

Agarkov N.M., Shamborskii V.N., Sukhoterin V.G., Kirichenko Yu.N., Lyutenko I.V. Ratsional'nye modeli diagnostiki khronicheskogo osteomielita chelyusti po parametram akupunkturnykh tochek. Sistemnyi analiz i upravlenie v biomeditsinskikh sistemakh. 2014;13:1:217-221.
Agarkov N.M., Gontarev S.N., Glagoleva Ya.V., Lutsenko V.D. Matematicheskoe modelirovanie diagnostiki osteomielita chelyustei i periodontita u detei. Sistemnyi analiz i upravlenie v biomeditsinskikh sistemakh. 2014;13:3:720-724.
Bulgakova A.I., Khismatullina F.R., Akhkamova T.M., Valeev I.V. Kharakteristika techeniya khronicheskogo generalizovannogo parodontita. Fundamental'nye issledovaniya. 2006;12:92-93.
Volozhin A.I., Poryadin G.V., Kazimirskii A.N. Immunologicheskie narusheniya v patogeneze khronicheskogo generalizovannogo parodontita. Stomatologiya. 2005;84:3:4-7.
Gil'miyarov E.M., Berezhnoi V.P., Gil'miyarova I.E., Tlusenko V.P. Kliniko-metabolicheskaya baza dannykh po khronicheskomu generalizovannomu parodontitu. Stomatologiya. 2008;87:5:23-30.
Kazarina L.N., Okulova Yu.V. Dinamika biokhimicheskikh pokazatelei u patsientov s khronicheskim geniralizovannym parodontitom pod vliyaniem KVCh terapii. Stomatologiya. 2007;86:4:22-24.
Lepilin A.V., Prilepskaya M.V., Raigorodskii Yu.M., Eliseev Yu.Yu. Kliniko-immunologicheskaya effektivnost' primeneniya vakuum- lazernoi terapii pri zabolevaniyakh parodonta. Stomatologiya. 2007;86:3:28-30.
Natsvlishvili T.T., Tsimbalistov A.V., Shtorina G.B. Kliniko-rentgenologicheskie paralleli generalizovannykh form agressivnogo i khronicheskogo parodontita. Vestnik Severo-Zapadnogo gosudarstvennogo meditsinskogo universiteta im. I.I. Mechnikova. 2011;3:4:97-100.