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Rabinovich O.F.

Otdelenie patologii slizistoĭ obolochki rta FGBU TsNIIS i ChLKh Minzdrava Rossii, Moskva

Ivina A.A.

Kafedra patologicheskoĭ anatomii meditsinskogo fakul'teta FGBOU VPO "Rossiĭskiĭ universitet druzhby narodov"

Guseva A.V.

Central Research Institute of Dental and Maxillofacial

Babichenko I.I.

Russian University of People’s Friendship, Moscow, Russia, 117198

Immunomorphology of oral lichen planus

Authors:

Rabinovich O.F., Ivina A.A., Guseva A.V., Babichenko I.I.

More about the authors

Journal: Stomatology. 2016;95(2): 4‑7

DOI: 10.17116/stomat20169524-7

Read: 1396 times

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Table of contents

IMMUNOMORPHOLOGY OF ORAL LICHEN PLANUS
IMMUNOMORPHOLOGY OF ORAL LICHEN PLANUS

To cite this article:

Rabinovich OF, Ivina AA, Guseva AV, Babichenko II. Immunomorphology of oral lichen planus. Stomatology. 2016;95(2):4‑7. (In Russ.)
https://doi.org/10.17116/stomat20169524-7

Подписка 2026 Стоматология (Stomatology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The article is devoted to immunohistochemical study of reticular and erosive forms of oral lichen planus. Morphological examination of the reticular form revealed the increased number of Langerhans cells (CD1a), mast cells (CD25) and T lymphocytes (CD4, CD8, CD16) in the oral epithelium. Activation of these cells leads to the secretion of TNF-α and destruction of basal keratinocytes, which manifests as a focal reduction of intercellular protein expression of E-cadherin. Destruction of basal keratinocytes in a reticular form of oral lichen planus is accompanied by a significant decrease in proliferative activity of the basal cell layer (21.7±10.2%) compared with normal mucosa (33.6±7.0%), p=0.0045. In erosive form along with the above changes IgG and C3d complement’s elements are revealed, which confirms the activation of immune complex mechanisms in the erosion area.

Keywords:

oral lichen planus
oral mucosa
immunohistochemistry

Authors:

Rabinovich O.F.

Otdelenie patologii slizistoĭ obolochki rta FGBU TsNIIS i ChLKh Minzdrava Rossii, Moskva

Ivina A.A.

Kafedra patologicheskoĭ anatomii meditsinskogo fakul'teta FGBOU VPO "Rossiĭskiĭ universitet druzhby narodov"

Guseva A.V.

Central Research Institute of Dental and Maxillofacial

Babichenko I.I.

Russian University of People’s Friendship, Moscow, Russia, 117198

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References:

  1. De Sousa FACG, Rosa LEB. Oral lichen planus: clinical and histopathological consideration. Brazilian Journal of Otorhinolaryngology. 2008;74(2):284-292. doi:10.1590/S0034-72992008000200021.
  2. Silverman SJr, Gorsky M, Lozada-Nur F, Giannotti K. A prospective study of finding and management in 214 patients with oral lichen planus. Oral Surg Oral Med Oral Pathol. 1991;72:665-670. doi:10.1016/0030-4220(91)90007-y.
  3. Canto AM, Muller H, Freitas RR, da Silva Santos PS. Oral lichen planus (OPL): clinical and complementary diagnosis. An Bras Dermatol. 2010;85(5):669-675. doi:10.1590/S0365-05962010000500010.
  4. Gandolfo S, Richiardi L, Carrozzo M et al. Risk of oral squamous cell carcinoma in 402 patiens with oral lichen planus: a follow-up study in an Italian population. Oral Oncol. 2004;40(1):77-83. doi:10.1016/s1368-8375(03)00139-8.
  5. Lodi G, Scully C, Carrozzo M et al. Current controversies in oral lichen planus: report of an international consensus meeting. Part 2. Clinical management and malignant transformation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;100(2):164-178. doi:10.1016/j.tripleo.2004.06.076.
  6. Prodromidis G, Nikitakis NG, Sklavounou A. Immunohistochemical analysis of the activation status of the Act/mTOR/pS6 signaling pathway in oral lichen planus. International Journal of Dentistry. 2013;2013:743456. doi: 10.1155/2013/743456.
  7. Akrish S, Ben-Izhak O, Sabo E, Rachmiel A. Oral squamous cell carcinoma associated with proliferative verrucous leukoplakia compared with conventional squamous cell carcinoma — a clinical, histologic and immunohistochemical study. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015;119(3):318-325. doi: 10.1016/j.oooo.2014.10.023.
  8. Sugerman PB, Savage NW, Walsh LJ et al. The pathogenesis of oral lichen planus. Crit Rev Oral Biol Med. 2002;13(4):350-365. doi:10.1177/154411130201300405.
  9. Mignoma MD, Fedele S, Lo Rosso L et al. Immune activation and chronic inflammation as the cause of malignancy in oral lichen planus: is there any evidence? Oral Oncol. 2004;40:120-130. doi:10.1016/j.oraloncology.2003.08.001.
  10. Lo Muzio L, Mignoma MD, Favia G et al. The possible association between oral lichen planus and oral squamous cell carcinoma: a clinical evaluation on 14 cases and review of the literature. Oral Oncol. 1998;34:239-246. doi:10.1016/s1368-8375(98)00001-3.
  11. Sugerman PB, Savage NW, Seymour GJ, Walsh LJ. Is there a role for tumor necrosis factor-α (FNO-α) in oral lichen planus? J Oral Pathol Med. 1996;25:219-224. doi:10.1111/j.1600-0714.1996.tb01375.x.
  12. Manish J, Sumita M, Nirmala NR et al. Histochemical analysis of pathological alterations in oral lichen planus and oral lichenoid lesions. Journal of Oral Science. 2006;48(4):185-193. doi:10.2334/josnusd.48.185.
  13. Pindborg JJ, Reichart P, Smith CJ, van der Waal I. In Collaboration with Sobin LHaPiC. Histological typing of cancer and precancer of the oral mucosa. 2nd ed. Berlin: Springer-Verlag; 1997.
  14. Hirota M, Ito T, Okudela K et al. Cell proliferation activity and the expression of cell cycle regulatory proteins in oral lichen planus. J Oral Pathol Med. 2002;31(4):204-212. doi:10.1034/j.1600-0714.2002.310403.x.
  15. Taniguchi Y, Nagao T, Maeda H et al. Epithelial cell proliferation in oral lichen planus. Cell Prolif. 2002;35:103-109. doi:10.1046/j.1365-2184.35.s1.11.x.
  16. Mattila R, Alanen K, Syrjanen S. Immunohistichemical study on topoisomeras II alpha, Ki-67 and cytokeratin-19 in oral lichen planus. Arch DermatolRes. 2007;298(8):381-388. doi:10.1007/s00403-006-0711-z.
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