Serum, oral and gingival fluid levels of heat shock protein-70, cytokines and their autoantibodies by periodontal disease

Tsybikov N.N.; Baranov S.V.; Kuznik B.I.; Malezhik L.P.; Isakova N.V.

doi:https://doi.org/

Tsybikov N.N.

Chita State Medical Academy, 672090, Chita, Russian Federation

Baranov S.V.

I.P. Pavlov Ryazan State Medical University, Ryazan

Kuznik B.I.

Kafedra normal'noĭ fiziologii i kafedra nervnykh bolezneĭ Chitinskoĭ gosudarstvennoĭ meditsinskoĭ akademii

Malezhik L.P.

GBOU VPO «Chitinskaja gosudarstvennaja meditsinskaja akademija» Minzdrava Rossii, Rossija

Isakova N.V.

Chitinskaia gosudarstvennaia meditsinskaia akademiia, Chita

Serum, oral and gingival fluid levels of heat shock protein-70, cytokines and their autoantibodies by periodontal disease

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Tsybikov N.N., Baranov S.V., Kuznik B.I., Malezhik L.P., Isakova N.V.

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Journal: Stomatology. 2014;93(1): 16‑18

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To cite this article:

Tsybikov NN, Baranov SV, Kuznik BI, Malezhik LP, Isakova NV. Serum, oral and gingival fluid levels of heat shock protein-70, cytokines and their autoantibodies by periodontal disease. Stomatology. 2014;93(1):16‑18. (In Russ.)

Подписка 2026 Стоматология (Stomatology)

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Abstract:

The study of 25 patients with periodontitis showed that the level of heat shock protein-70 (HSP70) and IL-1, IL-8 was increased in serum, buccal and gingival fluids as compared with healthy individuals, as well as the serum level of IgG autoantibodies both to HSP70 and to cytokines. In oral and gingival fluids sIgA autoantibodies to the same antigens were found. It was suggested that these autoantibodies can eliminate HSP-70 pro-inflammatory cytokines, thus regulating their levels in the inflammation area.

Keywords:

heat shock protein-70

proinflammatory cytokines

autoantibodies

periodontitis