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Klimova I.V.

V.I. Krasnopolsky Moscow Regional Research Institute of Obstetrics and Gynecology, Moscow, Russia

Efimkova E.B.

V.I. Krasnopolsky Moscow Regional Research Institute of Obstetrics and Gynecology, Moscow, Russia

Yarygina T.A.

V.I. Krasnopolsky Moscow Regional Research Institute of Obstetrics and Gynecology, Moscow, Russia

Cancer during pregnancy and fetal congenital malformations

Authors:

Klimova I.V., Efimkova E.B., Yarygina T.A.

More about the authors

Journal: Russian Bulletin of Obstetrician-Gynecologist. 2026;26(1): 33‑41

DOI: 10.17116/rosakush20262601133

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Table of contents

CANCER DURING PREGNANCY AND FETAL CONGENITAL MALFORMATIONS
CANCER DURING PREGNANCY AND FETAL CONGENITAL MALFORMATIONS

To cite this article:

Klimova IV, Efimkova EB, Yarygina TA. Cancer during pregnancy and fetal congenital malformations. Russian Bulletin of Obstetrician-Gynecologist. 2026;26(1):33‑41. (In Russ.)
https://doi.org/10.17116/rosakush20262601133

Подписка 2026 Российский вестник акушера-гинеколога (Russian Bulletin of Obstetrician-Gynecologist)
МСФ на ЯМ
Использование инфографики авторами научных работ
Recommended articles:
Multidisciplinary aspe­cts of pregnancy mana­gement in mate­rnal cancer and fetal malformations. Russian Bulletin of Obstetrician-Gynecologist. 2025;(6):69-76
Abstract:

Modern medical practice has seen an increase in the number of cases of malignant neoplasms diagnosed in women during pregnancy. Despite advances in research, many questions remain regarding the potential adverse effects of maternal cancer on the health of offspring. This literature review analyzes researchers’ hypotheses regarding the mechanisms by which maternal cancer influences fetal development, presents data on the incidence of congenital anomalies, and discusses the specifics of prenatal diagnosis in this patient population. According to current data, there is an association between maternal cancer and the risk of fetal congenital malformations, particularly in the cardiovascular, nervous, musculoskeletal, and respiratory systems. The highest risk of congenital anomalies is observed in leukemia and breast cancer. However, most studies do not demonstrate statistically significant results, indicating the need for additional multicenter and prospective studies. The importance of strengthening pregnancy monitoring, improving prenatal diagnostic methods, and implementing a personalized multidisciplinary approach to monitoring pregnant women with cancer is emphasized, which increases the chances of favorable outcomes for both mother and fetus.

Keywords:

pregnancy-associated cancer
fetal congenital malformations
prenatal diagnostics

Authors:

Klimova I.V.

V.I. Krasnopolsky Moscow Regional Research Institute of Obstetrics and Gynecology, Moscow, Russia

Efimkova E.B.

V.I. Krasnopolsky Moscow Regional Research Institute of Obstetrics and Gynecology, Moscow, Russia

Yarygina T.A.

V.I. Krasnopolsky Moscow Regional Research Institute of Obstetrics and Gynecology, Moscow, Russia

Received:

12.03.2025

Accepted:

07.04.2025

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References:

  1. Dagenais GR, Leong DP, Rangarajan S, Lanas F, Lopez-Jaramillo P, Gupta R, Diaz R, Avezum A, Oliveira GBF, Wielgosz A, Parambath SR, Mony P, Alhabib KF, Temizhan A, Ismail N, Chifamba J, Yeates K, Khatib R, Rahman O, Zatonska K, Kazmi K, Wei Li, Zhu J, Rosengren A, Vijayakumar K, Kaur M, Mohan V, Yusufali AH, Kelishadi R, Teo KK, Joseph P, Yusuf S. Variations in common diseases, hospital admissions, and deaths in middle-aged adults in 21 countries from five continents (PURE): a prospective cohort study. Lancet. 2020;395:785-794.  https://doi.org/10.1016/S0140-6736(19)32007-0
  2. Parakonnaya AA. Breast cancer and pregnancy. Zlokachestvennye opukholi. 2015;2:7-14. (In Russ.). https://doi.org/10.18027/2224-5057-2012-1-7-14
  3. Shmakov RG, Akhmedova AI, Polushkina ES, Demina EA, Mangasarova YaK, Tumyan GS. Modern principles of pregnancy management in patients with lymphomas. Akusherstvo i ginekologiya. 2019;7:40-48. (In Russ.). https://doi.org/10.18565/aig.2019.7.40-48
  4. Auger N, Maniraho A, Ayoub A, Arbour L. Association of maternal cancer with congenital anomalies in offspring. Paediatr Perinat Epidemiol. 2024;38:121-129.  https://doi.org/10.1111/ppe.13031
  5. Momen N, Ernst A, Arendt LH, Olsen J, Li J, Gissler M. Maternal cancer and congenital anomalies in children — a Danish nationwide cohort study. PLOS One. 2017;12:e0173355. https://doi.org/10.1371/journal.pone.0173355
  6. Dalmartello M, Negri E, La Vecchia C, Scarfone G, Buonomo B, Peccatori FA. Frequency of pregnancy-associated cancer: A Systematic review of population-based studies. Cancers (Basel). 2020;12:1356. https://doi.org/10.3390/cancers12061356
  7. Petkau VV, Kiseleva KE, Kiselev EA, Efremov SA, Ankudinov NO, Karimova AA. Malignant neoplasms associated with pregnancy: a population-based study. Zlokachestvennye opuholi. 2022;13:5-10. (In Russ.). https://doi.org/10.18027/2224-5057-2023-13-1-5-10
  8. Metcalfe A, Cairncross ZF, Friedenreich CM, Ray JG, Nelson G, Fell DB, Lisonkova S, Bhatti P, McMorris C, Sikdar KC, Shack L. Incidence of pregnancy-associated cancer in two canadian provinces: A Population-based study. Int J Environ Res Public Health. 2021;18:3100. https://doi.org/10.3390/ijerph18063100
  9. Safi N, Li Z, Anazodo A, Remond M, Hayen A, Currow D, Roder D, Hamad N, Nicholl M, Gordon A, Frawley J, Fotheringham P, Sullivan E. Pregnancy associated cancer, timing of birth and clinical decision making — a NSW data linkage study. BMC Pregnancy Childbirth. 2023;23:105.  https://doi.org/10.1186/s12884-023-05359-1
  10. Saad M, Murphy MSQ, McGee SF, El-Chaâr D. Pregnancy and neonatal outcomes following malignancy in pregnancy at a tertiary care Canadian center: a retrospective chart review. J Matern Fetal Neonatal Med. 2023;36:2198631. https://doi.org/10.1080/14767058.2023.2198631
  11. Cottreau CM, Dashevsky I, Andrade SE, Li D-K, Nekhlyudov L, Raebel MA, Ritzwoller DP, Partridge AH, Pawloski PA, Toh S. Pregnancy-Associated Cancer: A U.S. Population-Based Study. J Womens Health (Larchmt). 2019;28:250-257.  https://doi.org/10.1089/jwh.2018.6962
  12. Wu P, Jordan KP, Chew-Graham CA, Mohamed MO, Barac A, Lundberg GP. In-Hospital complications in pregnant women with current or historical cancer diagnoses. Mayo Clinic Proceedings. 2021;96:2779-2792. https://doi.org/10.1016/j.mayocp.2021.03.038
  13. Ma KK, Monsell SE, Chandrasekaran S, Gadi VK, Gammill HS. Cancer and pregnancy: National trends. Am J Perinatol. 2022; 39:144-153.  https://doi.org/10.1055/s-0040-1714394
  14. Javitt MC. Cancer in pregnancy: overview and epidemiology. Abdomin Radiol (NY). 2023;48:1559-1563. https://doi.org/10.1007/s00261-022-03633-y
  15. Pavlidis NA. Coexistence of pregnancy and malignancy. The Oncologist. 2002;7:279-87.  https://doi.org/10.1634/theoncologist.2002-0279
  16. Hepner A, Negrini D, Hase EA, Exman P, Testa L, Trinconi AF, Filassi JR, Francisco RPV, Zugaib M, O’Connor TL, Martin MG. Cancer during pregnancy: The Oncologist overview. World J Oncol. 2019;10:28-34.  https://doi.org/10.14740/wjon1177
  17. Pauker VA, Shmakov RG. Oncological diseases and pregnancy. Akusherstvo i ginekologiya. 2013;11:13-18. (In Russ.).
  18. Volochaeva MV, Polushkina ES, Shmakov RG, Shetikova OV. Pregnancy management in women with cancer (10 years of experience). Akusherstvo i ginekologiya. 2012;6:92-98. (In Russ.).
  19. Walters B, Midwinter I, Chew-Graham CA, Jordan KP, Sharma G, Chappell LC, Crosbie EJ, Parwani P, Mamas MA, Wu P. Pregnancy-associated cancer: A Systematic review and meta-analysis. Mayo Clin Proc Innov Qual Outcomes. 2024;8:188-199.  https://doi.org/10.1016/j.mayocpiqo.2024.02.002
  20. Esposito G, La Vecchia C, Fedele F, Parazzini F. Pregnancy-associated cancers: A Narrative review. Epidemiol Biostat Public Health. 2024;18:2:1-7.  https://doi.org/10.54103/2282-0930/22286
  21. Amant F, Lefrère H, Borges VF, Cardonick E, Lambertini M, Loibl S, Peccatori F, Partridge A, Schedin P. The definition of pregnancy-associated breast cancer is outdated and should no longer be used. Lancet Oncol. 2021;22:753-754.  https://doi.org/10.1016/S1470-2045(21)00183-2
  22. Padrul’ MM, Statnykh NV, Goffman TP, Polyakova TV. A clinical case of a combination of full-term pregnancy and stomach cancer. Voprosy onkologii. 2022;686:839-845. (In Russ.). https://doi.org/10.37469/0507-3758-2022-68-6-839-845
  23. Reutin MA, Kravtsova AA, Trashkov AP, Haitsev NV. Pregnancy and tumor growth: interrelations in clinical and experimental medicine. Pediatr. 2012;2:57-63. (In Russ.).
  24. Arnon J, Meirow D, Lewis-Roness H, Ornoy A. Genetic and teratogenic effects of cancer treatments on gametes and embryos. Hum Reprod Update. 2001;7:394-403.  https://doi.org/10.1093/humupd/7.4.394
  25. Wolters V, Heimovaara J, Maggen C, Cardonick E, Boere I, Lenaerts L, Amant F. Management of pregnancy in women with cancer. Int J Gynecol Cancer. 2021;31:314-322.  https://doi.org/10.1136/ijgc-2020-001776
  26. Graham JM Jr. Update on the gestational effects of maternal hyperthermia. Birth Defects Res. 2020;112:943-952.  https://doi.org/10.1002/bdr2.1696
  27. Applegate KE, Findlay Ú, Fraser L, Kinsella Y, Ainsbury L, Bouffler S. Radiation exposures in pregnancy, health effects and risks to the embryo/foetus — information to inform the medical management of the pregnant patient. J Radiol Prot. 2021;41:S522. https://doi.org/10.1088/1361-6498/ac1c95
  28. Rahimi R, Taylor M, Li X, Chen KL, MacLennan G, Murdoch E, Chang L, Parniani A, Wang P, Chawla A, Fan J, Kim D. Fetal dose assessment in a pregnant patient with brain tumor: A comparative study of proton PBS and 3DCRT/VMAT radiation therapy techniques. J Appl Clin Med Phys. 2024;25:e14394. https://doi.org/10.1002/acm2.14394
  29. Wong YM, Koh CWY, Lew KS, Chua CGA, Nei W, Tan HQ, Lee JCL, Mazonakis M, Damilakis J. A review on fetal dose in Radiotherapy: A historical to contemporary perspective. Phys Med: Eur J Med Physics. 2023;105:102513. https://doi.org/10.1016/j.ejmp.2022.102513
  30. Ohliger MA, Choi HH, Coutier J. Imaging safety and technical considerations in the reproductive age demale. Radiol Clin North Am. 2020;58:199-213.  https://doi.org/10.1016/j.rcl.2019.10.003
  31. Alghamdi SA. Gadolinium-based contrast agents in pregnant women: A Literature review of MRI safety. Cureus. 2023;15:e38493. https://doi.org/10.7759/cureus.38493
  32. National Toxicology P. NTP Monograph: Developmental effects and pregnancy outcomes associated with cancer chemotherapy use during pregnancy. NTP Monogr. 2013;2:214. 
  33. Koren G, Carey N, Gagnon R, Maxwell C, Nulman I, Senikas V. RETIRED: Cancer chemotherapy and pregnancy. J Obstet Gynaecol Can. 2013;35:263-278.  https://doi.org/10.1016/S1701-2163(15)30999-3
  34. Cardonick E, Bhat A, Gilmandyar D, Somer R. Maternal and fetal outcomes of taxane chemotherapy in breast and ovarian cancer during pregnancy: case series and review of the literature. Ann Oncol. 2012;23:3016-3023. https://doi.org/10.1093/annonc/mds170
  35. Serov VN, Shmakov RG, Polushkina ES, Volochaeva MV. Pregnancy and cancer. Russkii meditsinskii zhurnal. 2015;20:1195-1197. (In Russ.).
  36. van Gerwen M, Maggen C, Cardonick E, Verwaaijen EJ, van den Heuvel-Eibrink M, Shmakov RG, Boere I, Gziri MM, Ottevanger PB, Lok CAR, Halaska M, Shao LT, Struys I, van Dijk-Lokkart EM, Van Calsteren K, Fruscio R, Zola P, Scarfone G, Amant F; International Network on Cancer, Infertility and Pregnancy. Association of Chemotherapy Timing in Pregnancy With Congenital Malformation. JAMA Netw Open. 2021;4:e2113180. https://doi.org/10.1001/jamanetworkopen.2021.13180
  37. Lambertini M, Peccatori FA, Azim HA. Targeted agents for cancer treatment during pregnancy. Cancer Treatment Rev. 2015;41:301-309.  https://doi.org/10.1016/j.ctrv.2015.03.001
  38. Azim HA Jr, Azim H, Peccatori FA. Treatment of cancer during pregnancy with monoclonal antibodies: a real challenge. Expert Rev Clin Immunol. 2010;6:821-826.  https://doi.org/10.1586/eci.10.77
  39. Sorouri K, Loren AW, Amant F, Partridge AH. Patient-centered care in the management of cancer during pregnancy. Am Soc Clin Oncol Educ Book. 2023;43:e100037. https://doi.org/10.1200/EDBK_100037
  40. Shidlovskaya NV, Petrukhin VA, Burumkulova FF, Bashakin NF, Barinova IV. Thyroid cancer and pregnancy. Features of the course and perinatal outcomes. ssian Bulletin of Obstetrician-Gynecologist. 2017;17:6:83-88. (In Russ.). https://doi.org/10.17116/rosakush201717683-88
  41. Vysotskaya IV, Letyagin VP, Shabanov MA, Kirsanov VYu, Kim EA, Levkina NV. Current issues in carcinogenesis. Klinicheskaya onkogematologiya. 2019;12:1:101-106. (In Russ.). https://doi.org/10.21320/2500-2139-2019-12-1-101-106
  42. Margioula-Siarkou G, Margioula-Siarkou C, Petousis S, Vavoulidis E, Margaritis K, Almperis A. Breast carcinogenesis during pregnancy: Molecular mechanisms, maternal and fetal adverse outcomes. Biology. 2023;12:408.  https://doi.org/10.3390/biology12030408
  43. Mastromoro G, Guadagnolo D, Hashemian NK, Marchionni E, Traversa A, Pizzuti A. Molecular approaches in fetal malformations, dynamic anomalies and soft markers: Diagnostic rates and challenges — systematic review of the literature and meta-analysis. Diagnostics. 2022;12:575.  https://doi.org/10.3390/diagnostics12030575
  44. Vainio HV. Carcinogenesis and teratogenesis may have common mechanisms. Scand J Work Environ Health. 1989;15:13-17.  https://doi.org/10.5271/sjweh.1889
  45. Esposito G, Franchi M, Dalmartello M, Scarfone G, Negri E, Parazzini F, La Vecchia C, Corrao G. Obstetric and neonatal outcomes in women with pregnancy associated cancer: a population-based study in Lombardy, Northern Italy. BMC Pregnancy Childbirth. 2021;21:31.  https://doi.org/10.1186/s12884-020-03508-4
  46. Langagergaard V, Gislum M, Skriver MV, Nørgård B, Lash TL, Rothman KJ, Sørensen HT. Birth outcome in women with breast cancer. Br J Cancer. 2006;94:142-146.  https://doi.org/10.1038/sj.bjc.6602878
  47. Langagergaard V, Puho EH, Lash TL, Nørgård B, Sørensen HT. Birth outcome in Danish women with cutaneous malignant melanoma. Melanoma Res. 2007;17:31.  https://doi.org/10.1097/CMR.0b013e3280124749
  48. Langagergaard V, Horvath-Puho E, Nørgaard M, Nørgård B, Sørensen HT. Hodgkin’s disease and birth outcome: a Danish nationwide cohort study. Br J Cancer. 2008;98:183-188.  https://doi.org/10.1038/sj.bjc.6604126
  49. Greiber IK, Viuff JH, Mellemkjaer L, Hjortshøj CS, Lidegaard Ø, Storgaard L, Karlsen MA. Cancer in pregnancy and the risk of adverse pregnancy and neonatal outcomes: A nationwide cohort study. Br J Obstet Gynaecol. 2022;129:1492-1502. https://doi.org/10.1111/1471-0528.17074
  50. El-Messidi A, Patenaude VP, Abenhaim HAA. Incidence and outcomes of women with non-Hodgkin’s lymphoma in pregnancy: a population-based study on 7.9 million births. J Obstet Gynaecol Res. 2015;41:4:582-589.  https://doi.org/10.1111/jog.12597
  51. Shmakov RG, Demina EA, Komova TD, Pylova IV. Tactics of pregnancy management in women with oncohaematological diseases (part I — lymphoproliferative diseases). Klinicheskaya onkogematologiya. 2009;2:32-37. (In Russ.).
  52. Maggen C, Wolters VERA, Cardonick E, Fumagalli M, Halaska MJ, Lok CAR, de Haan J, Van Tornout K, Van Calsteren K, Amant F; International Network on Cancer, Infertility and Pregnancy (INCIP). Pregnancy and cancer: the INCIP project. Curr Oncol Rep. 2020;22:17.  https://doi.org/10.1007/s11912-020-0862-7
  53. de Haan J, Verheecke M, Van Calsteren K, Van Calster B, Shmakov RG, Gziri MM, Halaska MJ, Fruscio R, Lok CAR, Boere IA, Zola P, Ottevanger PB, de Groot CJM, Peccatori FA, Steffensen KD, Cardonick EH, Polushkina E, Rob L, Ceppi L, Sukhikh GT, Han SN, Amant F; International Network on Cancer and Infertility Pregnancy (INCIP). Oncological management and obstetric and neonatal outcomes for women diagnosed with cancer during pregnancy: a 20-year international cohort study of 1170 patients. Lancet Oncol. 2018;19:337-346.  https://doi.org/10.1016/S1470-2045(18)30059-7
  54. Amant F, Berveiller P, Boere IA, Cardonick E, Fruscio R, Fumagalli M, Halaska MJ, Hasenburg A, Johansson ALV, Lambertini M, Lok CAR, Maggen C, Morice P, Peccatori F, Poortmans P, Van Calsteren K, Vandenbroucke T, van Gerwen M, van den Heuvel-Eibrink M, Zagouri F, Zapardiel I. Gynecologic cancers in pregnancy: guidelines based on a third international consensus meeting. Ann Oncol. 2019;30:1601-1612. https://doi.org/10.1093/annonc/mdz228
  55. Halaska MJ, Komar M, Vlk R, Tomek V, Skultety J, Robova H, Rob L. A pilot study on peak systolic velocity monitoring of fetal anemia after administration of chemotherapy during pregnancy. Eur J Obstet Gynecol Reprod Biol. 2014;174:76-79.  https://doi.org/10.1016/j.ejogrb.2013.12.021
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