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Zaidieva Ya.Z.

Moscow Regional Research Institute of Obstetrics and Gynecology

Balan V.E.

Moscow Regional Scientific Research Institute of Obstetrics and Gynecology

Tsar’kova A.V.

Moscow Regional Research Institute of Obstetrics and Gynecology

Relationship between adipocytes and androgens — the cause of comorbidities in women with polycystic ovary syndrome

Authors:

Zaidieva Ya.Z., Balan V.E., Tsar’kova A.V.

More about the authors

Journal: Russian Bulletin of Obstetrician-Gynecologist. 2023;23(6): 25‑33

DOI: 10.17116/rosakush20232306125

Read: 1302 times

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Table of contents

RELATIONSHIP BETWEEN ADIPOCYTES AND ANDROGENS — THE CAUSE OF COMORBIDITIES IN WOMEN WITH POLYCYSTIC OVARY SYNDROME
RELATIONSHIP BETWEEN ADIPOCYTES AND ANDROGENS — THE CAUSE OF COMORBIDITIES IN WOMEN WITH POLYCYSTIC OVARY SYNDROME

To cite this article:

Zaidieva YaZ, Balan VE, Tsar’kova AV. Relationship between adipocytes and androgens — the cause of comorbidities in women with polycystic ovary syndrome. Russian Bulletin of Obstetrician-Gynecologist. 2023;23(6):25‑33. (In Russ.)
https://doi.org/10.17116/rosakush20232306125

Подписка 2025-2 (Russian Bulletin of Obstetrician-Gynecologist)
 
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The review presents the current knowledge about the relationship between androgens and adipocytes in women with polycystic ovary syndrome. Adipocytes are actively involved in steroid metabolism. The conversion of «weak» androgens to «strong» androgens takes place in them. In addition, adipocytes modulate ovarian production of testosterone and androstenedione through the action of various adipocytokines. Androgens also participate in the proliferation and differentiation of adipocytes, stimulate the secretion of adipocytokines and promote the accumulation of visceral adipose tissue. Androgens cause hypertrophy of adipocytes and contribute to the formation of insulin resistance in these cells. Androgens are known to increase insulin secretion by β-cells. Insulin, in turn, affects ovarian theca cells, leading to increased secretion of androgens. The described pathophysiological mechanisms contribute to the development of associated diseases and pathological conditions such as dyslipidemia, chronic inflammation of low intensity, non-alcoholic fatty liver disease, metabolic syndrome, type 2 diabetes mellitus, arterial hypertension and other cardiovascular diseases.

Keywords:

polycystic ovaries
hyperandrogenism
adipocytes
insulin resistance

Authors:

Zaidieva Ya.Z.

Moscow Regional Research Institute of Obstetrics and Gynecology

Balan V.E.

Moscow Regional Scientific Research Institute of Obstetrics and Gynecology

Tsar’kova A.V.

Moscow Regional Research Institute of Obstetrics and Gynecology

Received:

24.11.2022

Accepted:

20.12.2022

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