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Grechkanev G.O.

Privolzhsky Research Medical University

Kotova T.V.

Russian State Social University

Kachalina T.S.

Privolzhsky Research Medical University

Kuznetsova I.A.

Privolzhsky Research Medical University;
N.A. Semashko Nizhny Novgorod Regional Clinical Hospital

Krupinova D.S.

Medical Center «Clinic Aist»

Nikishov N.N.

Immanuel Kant Baltic Federal University

Klemente Kh.M.

Medical Center «Nika Spring Med»

Modern possibilities of conservative treatment of women with pelvic organ prolapse

Authors:

Grechkanev G.O., Kotova T.V., Kachalina T.S., Kuznetsova I.A., Krupinova D.S., Nikishov N.N., Klemente Kh.M.

More about the authors

Journal: Russian Bulletin of Obstetrician-Gynecologist. 2021;21(3): 46‑56

DOI: 10.17116/rosakush20212103146

Views: 2808

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Table of contents

MODERN POSSIBILITIES OF CONSERVATIVE TREATMENT OF WOMEN WITH PELVIC ORGAN PROLAPSE
MODERN POSSIBILITIES OF CONSERVATIVE TREATMENT OF WOMEN WITH PELVIC ORGAN PROLAPSE

To cite this article:

Grechkanev GO, Kotova TV, Kachalina TS, Kuznetsova IA, Krupinova DS, Nikishov NN, Klemente KhM. Modern possibilities of conservative treatment of women with pelvic organ prolapse. Russian Bulletin of Obstetrician-Gynecologist. 2021;21(3):46‑56. (In Russ.)
https://doi.org/10.17116/rosakush20212103146

 
 
Подписка 2025-2 (Russian Bulletin of Obstetrician-Gynecologist)
 
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A literature review based on an analysis of domestic and foreign sources published in recent years provides a modern understanding of the etiology and pathogenesis of a very common pathology — pelvic organ prolapse in women. Attention is paid to the genetic determinants of the disease, the role in its development of connective tissue dysplasia including those one associated with oxidative stress. The modern possibilities of conservative treatment of women with pelvic organ prolapse are disclosed. Among the methods for correcting prolapse the pharmacological drugs, training of the pelvic floor muscles, pessaries, methods of exposure to physical factors including laser therapy in various versions, contact diathermy, high-frequency radiotherapy with a detailed description of the mechanisms of their effectiveness are considered.

Keywords:

pelvic organ prolapse in women
etiology and pathogenesis
conservative treatment
pharmacotherapy
pelvic floor muscle training
targeted contact diathermy
laser technologies
high-frequency radiotherapy

Authors:

Grechkanev G.O.

Privolzhsky Research Medical University

Kotova T.V.

Russian State Social University

Kachalina T.S.

Privolzhsky Research Medical University

Kuznetsova I.A.

Privolzhsky Research Medical University;
N.A. Semashko Nizhny Novgorod Regional Clinical Hospital

Krupinova D.S.

Medical Center «Clinic Aist»

Nikishov N.N.

Immanuel Kant Baltic Federal University

Klemente Kh.M.

Medical Center «Nika Spring Med»

Received:

15.12.2020

Accepted:

30.01.2021

List of references:

  1. Chechneva MA, Barto RA, Budykina TS, Krasnopol’skaya IV, Abramyan KN. Current views on the pathogenesis, diagnosis and methods of correction of genital prolapse and its complications (literature review). Patogenez. 2014;12:4:4-9. (In Russ.).
  2. Dieter AA, Wilkins MF, Wu JM. Epidemiological trends and future care needs for pelvic floor disorders. Curr Opin Obstet Gynecol. 2015;27:5:380-384.  https://doi.org/10.1097/GCO.0000000000000200
  3. Wu JM, Vaughan CP, Goode PS, Redden DT, Burgio KL, Richter HE, Markland AD. Prevalence and trends of symptomatic pelvic floor disorders in U.S. Women. Obstet Gynecol. 2014;123:1:141-148.  https://doi.org/10.1097/AOG.0000000000000057
  4. Good MM, Solomon ER. Pelvic floor disorders. Obstet Gynecol Clin North Am. 2019;46:3:527-540.  https://doi.org/10.1016/j.ogc.2019.04.010
  5. Dubinskaya ED, Kolesnikova SN, Babicheva IA, Pyatykh NS. Anatomical features of pelvic floor structures in early forms of pelvic organ prolapse. Doktor.ru. Ginekologiya. Endokrinologiya. 2016;125(8)-126(9):21-24. (In Russ.).
  6. Dubinskaya ED, Babicheva IA, Kolesnikova SN. Personalized management tactics for patients with early forms of pelvic organ prolapse at reproductive age. Voprosy ginekologii, akusherstva i perinatologii. 2017;16:3:37-42. (In Russ.). https://doi.org/10.20953/1726-1678-2017-3-37-42
  7. Lagana AS, La Rosa VL, Rapisarda AMC, Vitale SG. Pelvic organ prolapse: the impact on quality of life and psychological well-being. J Psychosom Obstet Gynaecol. 2018;39:164-166.  https://doi.org/10.1080/0167482X.2017.1294155
  8. Vergeldt TF, Weemhoff M, IntHout J, Kluivers KB. Risk factors for pelvic organ prolapse and its recurrence: a systematic review. Int Urogynecol J. 2015;26:11:1559-1573. https://doi.org/10.1007/s00192-015-2695-8
  9. Bump RC, Norton PA. Epidemiology and natural history of pelvic floor dysfunction. Obstet Gynecol Clin North Am. 1998;25:4:723-746. 
  10. Wu JM, Matthews CA, Conover MM, Pate V, Jonsson Funk M. Lifetime risk of stress urinar incontinence or pelvic organ prolapse surgery. Obstet Gynecol. 2014;123:6:1201-1206. https://doi.org/10.1097/AOG.0000000000000286
  11. Luber KM, Boero S, Choe JY. The demographics of pelvic floor disorders: current observations and future projections. Am J Obstet Gynecol. 2001;184:7:1496-1501. https://doi.org/10.1067/mob.2001.114868
  12. Swenson CW, Morgan DM, George J, O DeLancey J. Effect of cystocele repair on cervix location in women with uterus in situ. Female Pelvic Med Reconstr Surg. 2018;24:1:56-59.  https://doi.org/10.1097/SPV.0000000000000438
  13. Blomquist JL, Muñoz A, Carroll M, Handa VL. Association of delivery mode with pelvic floor disorders after childbirth. JAMA. 2018;320:23:2438-2447. https://doi.org/10.1001/jama.2018.18315
  14. Gyhagen M, Bullarbo M, Nielsen TF, Milsom I. Prevalence and risk factors for pelvic organ prolapse 20 years after childbirth: a national cohort study in singleton primiparae after vaginal or caesarean delivery. BJOG. 2013;120:2:152-160.  https://doi.org/10.1111/1471-0528.12020
  15. Khaskheli M, Baloch S, Baloch AS. Obstetrical trauma to the tract following vaginal delivery. J Coll Physicians Surg Pak. 2012;22:2:95-97. 
  16. Patton V, Abraham E, Lubowski DZ. Sacral nerve stimulation for faecal incontinence: medium-term follow-up from a single institution. Aust N Z J Surg. 2017;87:6:462-466.  https://doi.org/10.1111/ans.13605
  17. Dietz H, Wilson P, Milsomc I. Maternal birth trauma: why should it matter to urogynaecologists? Curr Opin Obstet Gynecol. 2016;28:5:441-448.  https://doi.org/10.1097/GCO.0000000000000304
  18. Kamisan Atan I, Gerges B, Shek K, Dietz HP. The association between vaginal childbirth and hiatal dimensions: a retrospective observational study in a tertiary urogynaecological centre. Br J Obstet Gynaecol. 2015;122:6:867-872.  https://doi.org/10.1111/1471-0528.12920
  19. Manning S. Genital complaints at the extremes of age. Emerg Med Clin North Am. 2019;37:2:193-205.  https://doi.org/10.1016/j.emc.2019.01.003
  20. de Landsheere L, Blacher S, Munaut C, Nusgens B, Rubod C, Noel A, Foidart JM, Cosson M, Nisolle M. Changes in elastin density in different locations of the vaginal wall in women with pelvic organ prolapse. Int Urogynecol J. 2014;25:12:1673-1681. https://doi.org/10.1007/s00192-014-2431-9
  21. Orazov MR, Demyashkin GA, Toktar LR, Silant’eva ES, Khamoshina MB, Kampos ES, Lologaeva MS. Ultrastructural characteristics of pelvic floor tissues as a pathogenetic justification for the use of directed contact diathermy in pelvic organ prolapsed. Doktor.ru. 2017;142(13)-143(14):19-26. (In Russ.).
  22. Meijerink AM, van Rijssel RH, van der Linden PJQ. Tissue composition of the vaginal wall in women with pelvic organ prolapse. Gynecol Obstet Invest. 2013;75:1:21-27.  https://doi.org/10.1159/000341709
  23. Gong R, Xia Z. Collagen changes in pelvic support tissues in women with pelvic organ prolapse. Eur J Obstet Gynecol Reprod Biol. 2019;234:185-189.  https://doi.org/10.1016/j.ejogrb.2019.01.012
  24. Rynkevic R, Martins P, Andre A, Parente M, Mascarenhas T, Almeida H, Fernandes AA. The effect of consecutive pregnancies on the ovine pelvic soft tissues: Link between biomechanical and histological components. Ann Anat. 2019;222:166-172.  https://doi.org/10.1016/j.aanat.2018.12.002
  25. Kufaishi H, Alarab M, Drutz H, Lye S, Shynlova O. Comparative characterization of vaginal cells derived from premenopausal women with and without severe pelvic organ prolapse. Reprod Sci. 2016;23:7:931-943.  https://doi.org/10.1177/1933719115625840
  26. Bodner-Adler B, Bodner K, Kimberger O, Halpern K, Schneidinger C, Haslinger P, Schneeberger C, Horvat R, Umek W. The role of tenascin-X in the uterosacral ligaments of postmenopausal women with pelvic organ prolapse: an immunohistochemical study. Int Urogynecol J. 2020;31:1:101-106.  https://doi.org/10.1007/s00192-018-3820-2
  27. Sheyn D, Addae-Konaedu KL, Bauer AM, Dawodu KI, Hackney DN, El-Nashar SA. History of cervical insufficiency increases the risk of pelvic organ prolapse and stress urinary incontinence in parous women. Maturitas. 2018;107:63-67.  https://doi.org/10.1016/j.maturitas.2017.10.009
  28. Radzinskii VE, Khanzadyan ML, Demura TA. Matrix metalloproteinases and their inhibitors in the pathogenesis of pelvic organ prolapse. Doktor.ru. 2014;1:5:7-10. (In Russ.).
  29. Vetuschi A, D’Alfonso A, Sferra R, Zanelli D, Pompili S, Patacchiola F, Gaudio E, Carta G. Changes in muscularis propria of anterior vaginal wall in women with pelvic organ prolapse. Eur J Histochem. 2016;60:1:2604. https://doi.org/10.4081/ejh.2016.2604
  30. Wang X, Li Y, Chen J, Guo X, Guan H, Li C. Differential expression profiling of matrix metalloproteinases and tissue inhibitors of metalloproteinases in females with or without pelvic organ prolapse. Mol Med Rep. 2014;10:4:2004-2008. https://doi.org/10.3892/mmr.2014.2467
  31. Bhattarai A, Staat M. Modelling of soft connective tissues to investigate female pelvic floor dysfunctions. Comput Math Methods Med. 2018; Jan 15;2018:9518076. eCollection 2018. https://doi.org/10.1155/2018/9518076
  32. Vetuschi A, Pompili S, Gallone A, D’Alfonso A, Carbone MG, Carta G, Festuccia C, Eugenio Gaudio C, Colapietro A, Roberta Sferra R. Immunolocalization of advanced glycation end products, mitogen activated protein kinases, and transforming growth factor-P/smads in pelvic organ prolapse. J Histochem Cytochem. 2018;66:9:673-686.  https://doi.org/10.1369/0022155418772798
  33. Liu C, Wang Y, Li BS, Yang Q, Tang JM, Min J, Hong Sh, Guo WJ, Hong L. Role of transforming growth factor P1 in the pathogenesis of pelvic organ prolapse: A potential therapeutic target. Int J Mol Med. 2017;40:2:347-356.  https://doi.org/10.3892/ijmm.2017.3042
  34. Rusina EI, Bezhenar’ VF, Ivashchenko TE, Pakin VS, Baranov VS. Features of MMP1, MMR3, and PAI1 gene polymorphism in patients with pelvic organ prolapse and stress urinary incontinence. Akusherstvo i ginekologiya. 2014;9:63-68. 
  35. Consonni SR, Werneck CC, Sobreira DR, Kühne F, Guimarães Moraes S, Alvares L, Joazeiro P. Elastic fiber assembly in the adult mouse pubic symphysis during pregnancy and postpartum. Biol Reprod. 2012;86:5:151:1-10.  https://doi.org/10.1095/biolreprod.111.095653
  36. Rusina EI, Bezhenar’ VF, Ivashchenko TE, Pakin VS, Baranov VS. Features of polymorphism of the NAT2, GST t1, and GST m1 genes in women with pelvic organ prolapse and stress urinary incontinence. Arkhiv akusherstva i ginekologii im. V.F. Snegireva. 2014;1:2:36-40. (In Russ.).
  37. Kamoeva SV, Savchenko TN, Ivanova AV, Abaeva KhA. Modern genetic aspects of pelvic organ prolapse in women. Akusherstvo, ginekologiya i reproduktsiya. 2013;7:1:17-21. 
  38. Dubinskaya ED, Kolesnikova SN, Babicheva IA, Barabanova OE. Long-term results of conservative and surgical treatment of early stages of pelvic organ prolapse taking into account point mutations of the NAT2 gene. Zhurnal nauchnykh statei «Zdorov’e i obrazovanie v 21 veke». 2017;19:10:53-58. (In Russ.).
  39. Dubinskaya ED, Babicheva IA, Kolesnikova SN, Pyatykh NS. Long-term results of treatment of patients with early forms of pelvic organ prolapse. Voprosy ginekologii, akusherstva i perinatologii. 2016;15:5:13-19. (In Russ.).
  40. Arnouk A, De E, Rehfuss A, Cappadocia C, Dickson S, Lian F. Physical, complementary, and alternative medicine in the treatment of pelvic floor disorders. Curr Urol Rep. 2017;18:6:47.  https://doi.org/10.1007/s11934-017-0694-7
  41. Toktar LR. Women’s prolaptology: from pathogenesis to effectiveness of prevention and treatment. Akusherstvo i ginekologiya. Novosti. Mneniya. Obuchenie. 2017;3:98-107. (In Russ.).
  42. Loran OB, Seregin AS, Dovlatov ZA. Results of application of modern minimally invasive technologies in the treatment of pelvic organ prolapse in women. Eksperimental’naya i klinicheskaya urologiya. 2015;2:124-130. (In Russ.).
  43. Baessler K, Christmann-Schmid C, Maher C, Haya N, Crawford TJ, Brown J. Surgery for women with pelvic organ prolapse with or without stress urinary incontinence. Cochrane Database Syst Rev. 2018;8:8:CD013108. https://doi.org/10.1002/14651858.CD013108
  44. van der Ploeg JM, van der Steen A, Zwolsman S, van der Vaart CH, Roovers J. Prolapse surgery with or without incontinence procedure: a systematic review and meta-analysis. BJOG. 2018;125:3:289-297.  https://doi.org/10.1111/1471-0528.14943
  45. Jallad K, Ridgeway B, Paraiso MFR, Gurland B, Unger CA. Long-term outcomes after ventral rectopexy with sacrocolpo- or hysteropexy for the treatment of concurrent rectal and pelvic organ prolapse. Female Pelvic Med Reconstr Surg. 2018;24:5:336-340.  https://doi.org/10.1097/SPV.0000000000000444
  46. Maher C, Feiner B, Baessler K, Schmid C. Surgical management of pelvic organ prolapse in women. Cochrane Database Syst Rev. 2013;4:CD004014. https://doi.org/10.1002/14651858.CD004014.pub5
  47. Friedman T, Eslick GD, Dietz HP. Risk factors for prolapse recurrence: systematic review and meta-analysis. Int Urogynecol J. 2018;29:1:13-21.  https://doi.org/10.1007/s00192-017-3475-4
  48. Orazov MR, Toktar LR, Dostieva ShM, Gevorgyan DA, Lologaeva MS, Karimova GA. Pelvic organ prolapse is a problem that does not have an ideal solution. Trudnyi patsient. 2019;08-09:23-27. (In Russ.).
  49. Rahn DD, Good MM, Roshanravan SM, Shi H, Schaffer J, Singh RJ, Word R. Effects of preoperative local estrogen in postmenopausal women with prolapse: a randomized trial. J Clin Endocrinol Metab. 2014;99:10:3728-3736. https://doi.org/10.1210/jc.2014-1216
  50. Vaccaro CM, Mutema GK, Fellner AN, Crisp CC, Estanol MV, Kleeman SD, Pauls RN. Histologic and cytologic effects of vaginal estrogen in women with pelvic organ prolapse: a randomized controlled trial. Female Pelvic Med Reconstr Surg. 2013;19:1:34-39.  https://doi.org/10.1097/SPV.0b013e318278cc40
  51. Montoya TI, Maldonado PA, Acevedo JF, Word RA. Effect of vaginal or systemic estrogen on dynamics of collagen assembly in the rat vaginal wall. Biol Reprod. 2015;92:2:43.  https://doi.org/10.1095/biolreprod.114.118638
  52. Balgobin S, Montoya TI, Shi H, Acevedo JF, Keller PW, Riegel M, Wai CY, Word RA. Estrogen alters remodeling of the vaginal wall after surgical injury in guinea pigs. Biol Reprod. 2013;89:6:138.  https://doi.org/10.1095/biolreprod.113.112367
  53. Tyagi T, Alarab M, Leong Y, Lye S, Shynlova O. Local oestrogen therapy modulates extracellular matrix and immune response in the vaginal tissue of post-menopausal women with severe pelvic organ prolapse. J Cell Mol Med. 2019;23:4:2907-2919. https://doi.org/10.1111/jcmm.14199
  54. Florian-Rodriguez M, Chin K, Hamner J, Acevedo J, Keller P, Ann Word R. Effect of protease inhibitors in healing of the vaginal wall. Sci Rep. 2019;9:12354. https://doi.org/10.1038/s41598-019-48527-0
  55. Ripperda CM, Maldonado PA, Acevedo JF, Keller PW, Akgul Yu, Shelton JM, Word RA. Vaginal estrogen: a dual-edged sword in postoperative healing of the vaginal wall. Menopause. 2017;24:7:838-849. Published online 2017 Jun 26.  https://doi.org/10.1097/GME.0000000000000840
  56. Wasenda EJ, Kamisan Atan I, Subramaniam N, Dietz HP. Pelvic organ prolapse: does hormone therapy use matter? Menopause. 2017;24:10:1185-1189. https://doi.org/10.1097/GME.0000000000000898
  57. Dietz HP, Socha M, Atan IK, Subramaniam N. Does estrogen deprivation affect pelvic floor muscle contractility? Int Urogynecol J. 2020;31:1:191-196.  https://doi.org/10.1007/s00192-019-03909-w
  58. Minkin MJ, Maamari R, Reiter S. Improved compliance and patient satisfaction with estradiol vaginal tablets in postmenopausal women previously treated with another local estrogen therapy. Int J Womens Health. 2013;5:133-139. 
  59. Il’ina IYu, Dobrokhotova YuE. Non-surgical methods of correction of genital prolapse and urination disorders. Ginekologiya 2016;18:2:28-31. (In Russ.).
  60. Kim EJ, Chung N, Park SH, Lee KH, Kim SW, Kim JY, Bai SW, Jeon MJ. Involvement of oxidative stress and mitochondrial apoptosis in the pathogenesis of pelvic organ prolapse. J Urol. 2013;189:2:588-594. 
  61. Fang G, Hong L, Liu C, Yang Q, Zhang Q, Li Y, Li B, Wu D, Wu W, Shi H. Oxidative status of cardinal ligament in pelvic organ prolapse. Exp Ther Med. 2018;16:4:3293-3302. https://doi.org/10.3892/etm.2018.6633
  62. Hong S, Hong L, Li B, Wu D, Liu C, Min J, Guo W, Hu M, Tang J, Yang L. The role of GPX1 in the pathogenesis of female pelvic organ prolapse. PLoS One. 2017;12:8:e0181896. Published 2017 Aug 7.  https://doi.org/10.1371/journal.pone.0181896
  63. Marcu RD, Mischianu DLD, Iorga L, Diaconu CC, Surcel M, Munteanu AN, Constantin C, Isvoranu G, Bratu OG. Oxidative stress: A possible trigger for pelvic organ prolapse. J Immunol Res. 2020;3791934. https://doi.org/10.1155/2020/3791934
  64. Grechkanev GO, Kotova TV, Valentinova NN, Motovilova TM, Klemente Apumaita KhM, Nikishov NN, Gagaeva YuA, Keda AK, Kurmangulova IM, Gulyan ZhI, Kokova RR, Hasyanov IM. The role of enhanced lipoperoxidation in the pathogenesis of pelvic organ prolapse in women. Rossiiskii vestnik akushera-ginekologa. 2020;20:1:22-26. (In Russ.). https://doi.org/10.17116/rosakush20202001122
  65. Nygaard IE, Shaw JM. Physical activity and the pelvic floor. Am J Obstet Gynecol. 2016;214:2:164—171.  https://doi.org/10.1016/j.ajog.2015.08.067
  66. Ouchi M, Kato K, Gotoh M, Suzuki S. Physical activity and pelvic floor muscle training in patients with pelvic organ prolapse: a pilot study. Int Urogynecol J. 2017;28:12:1807-1815. https://doi.org/10.1007/s00192-017-3356-x
  67. Dobrokhotova YuE, Il’ina IYu. Effectiveness of conservative treatment of genital prolapse using a vaginal simulator. RMZH. Mat’ i ditya. 2017;25:26:1908-1912. (In Russ.).
  68. Dikke GB. Early diagnosis and conservative treatment of genital prolapse. Glavnyi vrach. 2017;53:1:23. (In Russ.).
  69. Hagen S, Stark D. Conservative prevention and management of pelvic organ prolapse in women. Cochrane Database Syst Rev. 2011;7:12:CD003882. https://doi.org/10.1002/14651858.CD003882
  70. Hagen S, Stark D, Glazener C, Dickson S, Barry S, Elders A, Frawley H, Galea MP, Logan J, McDonald A, McPherson G, Moore KH, Norrie J, Walker A, Wilson D. Individualised pelvic floor muscle training in women with pelvic organ prolapse (POPPY): a multicentre randomised controlled trial. Lancet. 2014;383:9919:796-806.  https://doi.org/10.1016/S0140-6736(13)61977-7
  71. Porta-Roda O, Vara-Paniagua J, Diaz-Lopez MA, Sobrado-Lozano P, Simó-González M, Díaz-Bellido P, Reula-Blasco M, Muñoz-Garrido F. Effect of vaginal spheres and pelvic floor muscle training in women with urinary incontinence: a randomized, controlled trial. Neurourol Urodyn. 2015;34:6:533-538.  https://doi.org/10.1002/nau.22640
  72. Deng M, Ding J, Ai F, Zhu L. Successful use of the Gellhorn pessary as a second-line pessary in women with advanced pelvic organ prolapse. Menopause. 2017;24:11:1277-1281. https://doi.org/10.1097/GME.0000000000000909
  73. Gorbunova EA, Yamurzina AA, Apolikhina IA. Urogynecological pessaries: practical skills for doctors. Akusherstvo i ginekologiya. 2017;12:115-121. (In Russ.). https://doi.org/10.18565/aig.2017.12.115-121
  74. Orazov MR, Demyashkin GA, Toktar LR, Silant’eva ES, Khamoshina MB, Kampos ES, Lologaeva MS. Ultrastructural characteristics of pelvic floor tissues as a pathogenetic justification for the use of directed contact diathermy in pelvic organ prolapse. Doktor.ru. 2017;13(142)-14(143):9-26. (In Russ.).
  75. Apolikhina IA, Chochuyeva AS, Saidova AS, Gorbunova EA, Kagan II. Modern approaches to the diagnosis and conservative treatment of genital prolapse in women in the practice of a gynecologist. Akusherstvo i ginekologiya. 2017;3:26-33. (In Russ.).
  76. Sorrell JM, Caplan AI. Fibroblasts — a diverse population at the center of it all. Int Rev Cell Mol Biol. 2009;276:161-214.  https://doi.org/10.1016/S1937-6448(09)76004-6
  77. Sardana K, Garg VK. Lasers in dermatological practice. 1st ed. New Delhi: Jaypee Brothers Medical Publishers (P) Ltd; 2014.
  78. Dobrokhotova YuE, Il’ina IYu, Venediktova MG, Morozova KV, Suvorova VA, Utina MS, Zalesskaya SA. The use of an erbium laser in the treatment of genitourinary syndrome in patients after radical treatment of uterine body cancer. Akusherstvo i ginekologiya. 2019;6:48-54. (In Russ.).
  79. Gambacciani M, Levancini M, Cervigni M. Vaginal erbium laser: the second-generation thermotherapy for the genitourinary syndrome of menopause. Climacteric. 2015;18:5:757-763.  https://doi.org/10.1097/GME.0000000000000761
  80. Gambacciani M, Placios S. Laser therapy for the restoration of vaginal function. Maturitas. 2017;99:10-15.  https://doi.org/10.1016/j.maturitas.2017.01.012
  81. Fistonić I, Fistonić N. Baseline ICIQ-UI score, body mass index, age, average birth weight, and perineometry duration as promising predictors of the short-term efficacy of Er: YAG laser treatment in stress urinary incontinent women: A prospective cohort study. Lasers Surg Med. 2018;23. Online ahead of print. https://doi.org/10.1002/lsm.22789
  82. Gaspar A, Brandi H, Gomez V, Luque D. Efficacy of Erbium: YAG laser treatment compared to topical estriol treatment for symptoms of genitourinary syndrome of menopause. Lasers Surg Med. 2017;49:2:160-168.  https://doi.org/10.1002/lsm.22569
  83. Bezmenko AA, Shmidt AA, Koval’ AA, Sibirev SA, Karpishchenko ZhM, Gaivoronskikh DI. Morphological justification of the use of Er:YAG laser for the treatment of stress urinary incontinence in women. Zhurnal akusherstva i zhenskikh boleznei. 2014;63:3:21-25. (In Russ.).
  84. Gaspar A, Addamo G, Brandi H. Vaginal fractional CO2 laser: A minimally invasive option for vaginal rejuvenation. Am J Cosmetic Surg. 2011;28:3:156-162.  https://doi.org/10.1177/074880681102800309
  85. Athanasiou S, Pitsouni E, Antonopoulou S, Zacharakis D, Salvatore S, Falagas M, Grigoriadis T. The effect of microablative fractional CO2 laser on vaginal flora of postmenopausal women. Climacteric. 2016;19:512-518.  https://doi.org/10.1080/13697137.2016.1212006
  86. Salvatore S, Leone Roberti Maggiore U, Athanasiou S, Origoni M, Candiani M, Calligaro A, Zerbinati N. Histological study on the effects of microablative fractional CO2 laser on atrophic vaginal tissue: an ex vivo study. Menopause. 2015;22:8:845-849.  https://doi.org/10.1097/GME.0000000000000401
  87. Ishchenko AA, Ishchenko AI, Shul’china IV, Muravlev AI. Use of laser technologies in a complex of arrangements to patients operated for the genital prolapse. Gynekologiya. 2016;18:1:54-55. (In Russ.).
  88. Kwon TR, Kim JH, Seok J, Kim JM, Bak DH, Choi MJ, Mun SK, Kim CW, Ahn S, Kim B. Fractional CO2-laser treatment for vaginal laxity: A preclinical study. J Lasers Surg Med. 2018;50:9:940-947.  https://doi.org/10.1002/lsm.22940
  89. Cruz VL, Steiner ML, Pompei LM, Strufaldi R, L Afonso Fonseca F, Santiago L, Wajsfeld T, Fernandes C. Randomized, doubleblind, placebo‐controlled clinical trial for evaluating the efficacy of fractional CO2-laser compared with topical estriol in the treatment of vaginal atrophy in postmenopausal women. Menopause. 2018;25:1:21-28.  https://doi.org/10.1097/GME.0000000000000955
  90. Paraiso MFR, Ferrando CA, Sokol ER, Rardin CR, Matthews CA, Karram MM, Iglesia CB. A randomized clinical trial comparing vaginal laser therapy to vaginal estrogen therapy in women with genitourinary syndrome of menopause: The VeLVET Trial. Menopause. 2020;27:1:50-56.  https://doi.org/10.1097/GME.0000000000001416
  91. Shobeiri SA, Kerkhof MH, Minassian VA, Bazi T. IUGA Research and Development Committee. IUGA committee opinion: laser-based vaginal devices for treatment of stress urinary incontinence, genitourinary syndrome of menopause, and vaginal laxity. Int Urogynecol J. 2019;30:3:371-376.  https://doi.org/10.1007/s00192-018-3830-0
  92. Okui N. Comparison between erbium‐doped yttrium aluminum garnet laser therapy and sling procedures in the treatment of stress and mixed urinary incontinence. World J Urol. 2019;37:885-889.  https://doi.org/10.1007/s00345‐018‐2445‐x
  93. Okui N. Efficacy and safety of non‐ablative vaginal erbium:YAG laser treatment as a novel surgical treatment for overactive bladder syndrome: comparison with anticholinergics and β3 adrenoceptor agonists. World J Urol. 2019;37:2459-2466. https://doi.org/10.1007/s00345-019-02644-7
  94. Bhide AA, Khullar V, Swift S, Digesu GA. The use of laser in urogynaecology. Int Urogynecol J. 2019;30:5:683-692.  https://doi.org/10.1007/s00192-018-3844-7
  95. Haylen BT, Maher CF, Barber MD, Camargo S, Dandolu V, Digesu A, Goldman HB., Huser M, Milani AL, Moran PA, Schaer GN, Withagen MI. An International Urogynecological Association (IUGA)/International Continence Society (ICS) joint report on the terminology for female pelvic organ prolapse (POP). Neurourol Urodyn. Int Urogynecol J. 2016;27:4:655-684.  https://doi.org/10.1007/s00192-016-3003-y
  96. Karcher C, Sadick N. Vaginal rejuvenation using energy‐based devices. Int J Womens Dermatol. 2016;2:85-88.  https://doi.org/10.1016/j.ijwd.2016.05.003
  97. Flint R, Cardozo L, Grigoriadis T, Rantell A, Pitsouni E, Athanasiou S. Rationale and design for fractional microablative CO2-laser versus photothermal non‐ablative erbium: YAG-laser for the management of genitourinary syndrome of menopause: a noninferiority, single‐blind randomized controlled trial. Climacteric. 2019;22:3:307-311.  https://doi.org/10.1080/13697137.2018.1559806
  98. Mackova K, Van Daele L, Page A-S, Geraerts I, Krofta L, Deprest J. LASER therapy for urinary incontinence and pelvic organ prolapse: a systematic review. BJOG. 2020;127:11:1338-1346. https://doi.org/10.1111/1471-0528.16273
  99. FDA Warning. FDA warns against use of energy‐ based devices to perform vaginal «rejuvenation» or vaginal cosmetic procedures: FDA Safety Communication. 2018.
  100. Leibaschoff G, Gonzales Izasa P, Cardona JL, Miklos JR, Moore RD. Transcutaneous temperature controlled radiofrequency for the treatment of menopausal vaginal/genitourinary symptoms. Surg Technol Int. 2016;29:149-159. 
  101. Kang D, Han J, Neuberger MM, Moy M, Wallace S, Alonso-Coello P, Dahm P. Transurethral radiofrequency collagen denaturation for the treatment of women with urinary incontinence. Cochrane Database Syst Rev. 2015;18:3:CD010217. https://doi.org/10.1002/14651858.CD010217.pub2
  102. Caruth JC. Evaluation of the safety and efficacy of a novel radiofrequency device for vaginal treatment. Surg Technol Int. 2018;32:145-149. 
  103. Gold M, Andriessen A, Bader A, Alinsod R, French ES, Guerette N, Kolodchenko Y, Krychman M, Murrmann S, Samuels J. Review and clinical experience exploring evidence, clinical efficacy, and safety regarding nonsurgical treatment of feminine rejuvenation. J Cosmet Dermatol. 2018;17:3:289-297.  https://doi.org/10.1111/jocd.12524
  104. Vicariotto F, Raichi M. Technological evolution in the radiofrequency treatment of vaginal laxity and menopausal vulvovaginal atrophy and other genitourinary symptoms: first experiences with a novel dynamic quadripolar device. Minerva Ginecol. 2016;68:3:225-236. PMID: 27206062.
  105. Vicariotto F, Seta F, Faoro V, Raichi M. Dynamic quadripolar radiofrequency treatment of vaginal laxity/menopausal vulvo‐vaginal atrophy: 12‐month efficacy and safety. Minerva Ginecol. 2017;69:4:342-349.  https://doi.org/10.23736/S0026-4784.17.04072-2
  106. Dobrokhotova YuE, Nagieva TS, Il’ina IYu, Kareva EN, Kochina NA, Zragus EV, Dobrova AB, Shakhmaratova IA, Krasnoshchok EV. Influence of radiofrequency non-ablative influence on the expression of connective tissue proteins of the urogenital tract in patients with relaxed vagina syndrome in the postpartum period. Akusherstvo i ginekologiya. 2019;8:119-125. (In Russ.). https://doi.org/10.18565/aig.2019.8.119-125
  107. Rahajeng R. The increased of MMP-9 and MMP-2 with the decreased of TIMP- 1 on the uterosacral ligament after childbirth. Pan Afr Med J. 2018;30:283.  https://doi.org/10.11604/pamj.2018.30.283.9905
  108. Wang S, Lu D, Zhang Z, Jia X, Yang L. Effects of mechanical stretching on the morphology of extracellular polymers and the mRNA expression of collagens and small leucine-rich repeat proteoglycans in vaginal fibroblasts from women with pelvic organ prolapse. PLoS One. 2018;13:4:e0193456. https://doi.org/10.1371/journal.pone.0193456
  109. Perineology. Aesthetic gynecology. Ed. by V.E. Radzinskii. Moscow: Redaktsiya zhurnala StatusPresens; 2020;416. (In Russ.).

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