The role of inflammatory response markers in predicting premature birth

Kosyakova O.V.; Bespalova O.N.; Seyidova Ch.I.; Glotov A.S.

doi:https://doi.org/10.17116/rosakush20202003118

Kosyakova O.V.

D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology, St. Petersburg, Russia

Bespalova O.N.

D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology, Saint Petersburg, Russia

Seyidova Ch.I.

D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology, St. Petersburg, Russia

Glotov A.S.

The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott, Saint Petersburg, Russia

The role of inflammatory response markers in predicting premature birth

Authors:

Kosyakova O.V., Bespalova O.N., Seyidova Ch.I., Glotov A.S.

More about the authors

Journal: Russian Bulletin of Obstetrician-Gynecologist. 2020;20(3): 18‑23

DOI: 10.17116/rosakush20202003118

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To cite this article:

Kosyakova OV, Bespalova ON, Seyidova ChI, Glotov AS. The role of inflammatory response markers in predicting premature birth. Russian Bulletin of Obstetrician-Gynecologist. 2020;20(3):18‑23. (In Russ.)
https://doi.org/10.17116/rosakush20202003118

Подписка 2026 Российский вестник акушера-гинеколога (Russian Bulletin of Obstetrician-Gynecologist)

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Abstract:

Recent data on the frequency of premature births and their outcomes for both the mother and the fetus are disappointing: the number of premature births continues to grow every year, varying from 5 to 18%, and prematurity remains the leading cause of death and disability for children around the world. Many of adverse consequences determines the priority of tasks to find mechanisms to reduce the frequency of premature births, the implementation of which is possible only with timely, pathogenetically sound forecasting, balanced assessment and effective risk management. The expansion of perceptions about pathological mechanisms has determined the integral role of infectious and inflammatory processes in the initiation of premature labor. At the same time, it seems important, but not completely solved, problem to determine the prognostic value of identification of the inflammatory biomarkers in relation to realisation of premature birth and adverse perinatal outcomes. This review discusses the characteristics of infectious, immunological, molecular genetic (genomic and transcriptomic) and proteomic inflammatory biomarkers of premature birth, modern data on the possibility of evaluating them not only as predictors, but also as potential targets for therapeutic effects.

Keywords:

biomarkers

inflammation

infection

premature birth

prognosis

predictors

Authors:

Kosyakova O.V.

D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology, St. Petersburg, Russia

Bespalova O.N.

D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology, Saint Petersburg, Russia

Seyidova Ch.I.

D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology, St. Petersburg, Russia

Glotov A.S.

The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott, Saint Petersburg, Russia

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