Objective — evaluation of clinical efficacy of the drug «Pineamin, GEROPHARM LLC (Russia)— in patients with premature ovarian insufficiency and reduced ovarian reserve. Material and methods. 66 women aged 18—45 years were examined with a diagnosis of premature ovarian failure. The first group included 22 patients who received a dose of 10 mg of pineamine from the 5th to 14th days of the menstrual cycle or in the absence of menstruation outside the cycle to correct vegetative disorders. The second group included 22 patients who received the preparation containing 2 mg of estradiol and 10 mg of diderogesterone from the 1st day of the menstrual cycle or against a background of a long delay of menstruation at a thickness of endometrium less than 4 mm and pineamine according to the above scheme. Group 3 22 women received only a preparation containing 2 mg of estradiol and 10 mg of diderogesterone according to a similar scheme. The influence of pineamine on the level of LH, FSH, antimuller hormone, estradiol, kisspeptin and on the growth of anthral follicles according to ultrasound data before and after treatment was assessed. Results. Statistically significant difference in the levels of LH, FSH and antimuler hormone in the patients of the studied groups before and after treatment was not found. However, when comparing the indicators before and after treatment, significant changes were found in each individual group: a decrease in the content of LHG and FSH, as well as an increase in estradiol levels. Statistically significant differences in the level of kisspeptin in the groups studied were initially detected. After treatment, the diameter of the follicle increased: the maximum diameter was set in the 2nd group (more than 4 times), the minimum — in the 3rd group. Yellow body was visualized: in the 2nd group — in 13 women, in the 3rd group — in 1 patient, in the 1st group — was not determined. Conclusion. Combined therapy with pineamine and estrogen-gestagenic drug in patients with premature ovarian insufficiency and reduced ovarian reserve had a stimulating effect on the growth of follicles and in 59% of observations led to maturation of the yellow body in comparison with the groups of monotherapy with pineamine or estrogen-gestagenic drug.