Modern methods of correction of age-related changes in the female body

Manasova Z.Sh.; Andriutsa N.S.; Ershov A.V.; Yureneva S.V.

doi:https://doi.org/10.17116/plast.hirurgia202501190

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Abstract:

The article is devoted to the study of the processes occurring in the female body during the extinction of reproductive function, characterized by physical, endocrine, and psychological changes that negatively affect the quality of life. The role of the pineal gland hormone melatonin in the development of age-related changes in the body is reflected. The prospects of using a drug based on Pineamine polypeptides and modern laser therapy methods in the treatment of pathological conditions associated with hormonal imbalance due to age-related changes in the reproductive system or diseases accompanied by premature ovarian insufficiency have been studied. Based on the literature analysis, conclusions can be drawn about the high efficiency and safety of these methods. Of great interest is the study of the effectiveness of the combined use of these methods, which requires further research.

Keywords:

hypoestrogenia

vaginal atrophy

collagen

elastin

melatonin

Pineamine

Authors:

Manasova Z.Sh.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

ORCID: 0000-0002-3003-4362

Andriutsa N.S.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

ORCID: 0000-0001-5425-7707

Ershov A.V.

Sechenov First Moscow State Medical University (Sechenov University);
Negovsky Research Institute of General Reanimatology — Federal Research and Clinical Center for Reanimatology and Rehabilitology

ORCID: 0000-0001-5758-8552

Yureneva S.V.

Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology

ORCID: 0000-0003-2864-066X

Received:

18.12.2024

Accepted:

10.01.2025

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References:

Shishkova VN. Psychoemotional and autonomic disorders in pre-, peri-, and postmenopausal women. Meditsinskij sovet. 2024;18(12):70-76. (In Russ.). https://doi.org/10.21518/ms2024-269
Tazina TV, Knyazeva AV, Bebneva TV. Modern solution to the problem of vaginal dryness. Russkij meditsinskij zhurnal. Mat’ i ditya. 2021;4(3):250-253. (In Russ.). https://doi.org/10.32364/2618-8430-2021-4-3-250-253
Grechkanev GO, Motovilova TM, Klemente KhM, Nikishov NN, Krupinova DS, Gagaeva YuA, Shcherina AV, Gulyan ZhI. Pathogenesis and pathogenetic treatment of menopausal coronary syndrome (literature review). Meditsinskij al’manakh.2020;3(64):6-14. (In Russ.).
Andreeva EN, Absatarova YuS. Melatonin status disorders in gynecological practice: pathogenetic aspects and therapeutic possibilities. Rossijskij vestnik akushera-ginekologa. 2022;22(6):48-53. (In Russ.). https://doi.org/10.17116/rosakush20222206148
Talaulikar V. Menopause transition: Physiology and symptoms. Best Pract Res Clin Obstet Gynaecol. 2022;81:3-7. https://doi.org/10.1016/j.bpobgyn.2022.03.003
Prilepskaya VN, Bogatova IK, Radzinskij VE. New in the prevention and treatment of menopausal syndrome. Ginekologiya. 2016;18(1):7-12. (In Russ.).
Kamp E, Ashraf M, Musbahi E, DeGiovanni C. Menopause, skin and common dermatoses. Part 1: hair disorders. Clin Exp Dermatol. 2022;47(12): 2110-2116. https://doi.org/10.1111/ced.15327
Li M, Zhu Y, Wei J, Chen L, Chen S, Lai D. The global prevalence of premature ovarian insufficiency: a systematic review and meta-analysis. Climacteric. 2023;26(2): 95-102. https://doi.org/10.1080/13697137.2022.2153033
Skurikhina NV, Kunaeva AI, Shumkova EN. Pathohistological features of “fading skin and methods of their correction”. Meditsina (Almaty). 2019; 1(199):32-39. (In Russ.). https://doi.org/10.31082/1728-452x-2019-199-1-32-39
Santoro N, Roeca C, Peters BA, Neal-Perry G. The Menopause Transition: Signs, Symptoms, and Management Options. J Clin Endocrinol Metab. 2021;106(1):1-15. https://doi.org/10.1210/clinem/dgaa764
Ma L-P, Liu M-M, Liu F, Sun B, Wang S-N, Chen J, Yu H-J, Yan J, Tian M, Gao L, Liu Q-J. Melatonin inhibits senescence-associated melanin pigmentation through the p53-TYR pathway in human primary melanocytes and the skin of C57BL/6 J mice after UVB irradiation. J Mol Med (Berl). 2023;101(5):581-593. https://doi.org/10.1007/s00109-023-02301-y
Zouboulis CC, Blume-Peytavi U, Kosmadaki M, Roó E, Vexiau-Robert D, Kerob D, Goldstein SR. Skin, hair and beyond: the impact of menopause. Climacteric. 2022;25(5):434-442. https://doi.org/10.1080/13697137.2022.2050206
Mamontova AG, Usoltseva EN, Pisklakova TP, Lepikhina EM, Nikushkina KV. Triggers and markers of skin aging in women with menopausal syndrome Meditsinskij sovet. 2021;21-2:86-92. (In Russ.). https://doi.org/10.21518/2079-701x-2021-21-2-86-92
Kamp E, Ashraf M, Musbahi E, DeGiovanni C. Menopause, skin and common dermatoses. Part 2: skin disorders. Clin Exp Dermatol. 2022;47(12): 2117-2122. https://doi.org/10.1111/ced.15308
Kuznetsova IV. Vaginal dryness and quality of life in mature women. Consilium Medicum. 2020;22(6):9-14. (In Russ.).
Tikhomirova EV, Balan VE, Fomina-Nilova OS. Methods of treatment of genitourinary syndrome at the present stage. Meditsinskij sovet. 2020;13:91-96. (In Russ.). https://doi.org/10.21518/2079-701x-2020-13-91-96
Goncharenko V, Bubnov R, Polivka Jr J, Zubor P, Biringer K, Bielik T, Kuhn W, Golubnitschaja O. Vaginal dryness: individualised patient profiles, risks and mitigating measures. EPMA J. 2019;10(1):73-79. https://doi.org/10.1007/s13167-019-00164-3
Benini V, Ruffolo AF, Casiraghi A, Degliuomini RS, Frigerio M, Braga A, Serati M, Torella M, Candiani M, Salvatore S. New Innovations for the Treatment of Vulvovaginal Atrophy: An Up-to-Date Review. Medicina (Kaunas). 2022;58(6):770. https://doi.org/10.3390/medicina58060770
Dobroxotova YuE, Borovkova EI, Zalesskaya SA. Atrophic vaginitis in patients of reproductive age. Voprosy ginekologii, akusherstva i perinatologii. 2021;20(3):42-47. (In Russ.). https://doi.org/10.20953/1726-1678-2021-3-42-47
Drozhdina MB. Vaginal microbiota, immune response and some sexually transmitted infections: mechanisms of interaction and regulation of the vaginal ecosystem. Russian Journal of Clinical Dermatology and Venereology. 2020;19(6):926-933. (In Russ.). https://doi.org/10.17116/klinderma202019061926
Antimonova OI, Galkina OV, Morozkina SN, Shavva AG. Steroidal estrogens as antioxidants. Vestnik Sankt-Peterburgskogo universiteta. Fizika i khimiya. 2012;3:79-95. (In Russ.).
Bourgonje AR, Abdulle AE, Al-Rawas AM, Al-Maqbali M, Al-Saleh M, Enriquez MB, Al-Siyabi S, Al-Hashmi K, Al-Lawati I, Bulthuis MLC, Mulder DJ, Gordijn SJ, van Goor H, Saleh J. Systemic Oxidative Stress Is Increased in Postmenopausal Women and Independently Associates with Homocysteine Levels. Int J Mol Sci. 2020;21(1):314. https://doi.org/10.3390/ijms21010314
Denisova AA, Granatovich NN. Modern methods used in aesthetic gynecology (a brief review of the literature). Vestnik novykh meditsinskikh tekhnologij. Elektronnoe izdanie. 2022;16(2):44-48. (In Russ.).
Boris DA, Tarnaeva LA, Apolixina IA, Sokolova AV, Svidzinskaya NV. Modern trends in aesthetic gynecology. Zhenskoe zdorov’e i reproduktsiya. 2024;2(63): 32-48. (In Russ.). https://doi.org/10.31550/2712-8598-2024-2-4-zhzir
Saidova AS, Apolixina IA. The first experience of using an innovative diode laser for the treatment of genitourinary menopausal syndrome in women. Akusherstvo i ginekologiya. 2024;7:130-134. (In Russ.). https://doi.org/10.18565/aig.2024.173
Bakhtiyarov KR, Chilova RA, Sardarova ShSh. Diagnosis and modern methods of treatment of vulvovaginal atrophy in postmenopausal women. Lechashchij vrach. 2021;12:17-21. (In Russ.). https://doi.org/10.51793/os.2021.24.12.002
Ikonnikova EV, Avagumyan MA. The possibilities of laser technologies in the correction of non-cancerous melanin hyperpigmentation of the skin of the anogenital region. Meditsinskij alfavit. 2019;1(7):94-99. (In Russ.). https://doi.org/10.33667/2078-5631-2019-1-7(382)-94-99
Kulikov IA, Apolikhina IA, Gevorkyan GA. Photothermal tissue reconstruction and the use of phytoestrogens in the treatment of genitourinary menopausal syndrome. Medicinskij sovet. 2024;18(4):156-167. (In Russ.). https://doi.org/10.21518/ms2024-155
Kruglova LS, Surkichin SI, Avin M. The use of laser technologies in genitourinary menopausal syndrome. Plastic Surgery and Aesthetic Medicine. 2023;2:81-86. (In Russ.). https://doi.org/10.17116/plast.hirurgia202302181
Saidova AS, Sencha AN, Apolikhina IA. Carboxytherapy of genitourinary menopausal syndrome. Akusherstvo i ginekologiya. 2020;5:113-121. (In Russ.). https://doi.org/10.18565/aig.2020.5.113-21
Khabarov SV, Sterlikova NA. Melatonin and its role in circadian regulation of reproductive function (literature review). Vestnik novykh meditsinskikh tekhnologij. 2022;29(3):17-31. (In Russ.).
Greendale GA, Witt-Enderby P, Karlamangla AS, Munmun F, Crawford S, Huang M, Santoro N. Melatonin Patterns and Levels During the Human Menstrual Cycle and After Menopause. J Endocr Soc. 2020;4(11):115. https://doi.org/10.1210/jendso/bvaa115
Petrov YuA, Shelemekh KE, Kupina AD. The effect of melatonin on the reproductive system in different periods of a woman’s life. Mat’ i ditya v Kuzbasse. 2021;2(85):26-31. (In Russ.).
Mineiro R, Cardoso MR, Pinheiro JV, Cipolla-Neto J, do Amaral FG, Quintela T. Overlapping action of melatonin and female reproductive hormones-Understand the impact in pregnancy and menopause. Adv Protein Chem Struct Biol. 2024;142:163-190. https://doi.org/10.1016/bs.apcsb.2024.06.005
Sevilla A, Chéret J, Slominski RM, Slominski AT, Paus R. Revisiting the role of melatonin in human melanocyte physiology: A skin context perspective. J Pineal Res. 2022;72(3):12790. https://doi.org/10.1111/jpi.12790
Tsenteradze SL, Poluektov MG. Clinical aspects of the use of melatonin preparations. Meditsinskij sovet. 2021;10:80-84 (In Russ.). https://doi.org/10.21518/2079-701X-2021-10-80-84
Sobolevskaya IS, Zykova OS, Myadelets OD. The role of melatonin in the physiology and pathology of the skin. Russian Journal of Clinical Dermatology and Venereology. 2018;17(60):116-123. (In Russ.). https://doi.org/10.17116/klinderma201817061116
Samra T, Gomez-Gomez T, Linowiecka K, Akhundlu A, Lopez de Mendoza G, Gompels M, Lee WW, Gherardini J, Chéret J, Paus R. Melatonin Exerts Prominent, Differential Epidermal and Dermal Anti-Aging Properties in Aged Human Eyelid Skin Ex Vivo. Int J Mol Sci. 2023;24(21):15963. https://doi.org/10.3390/ijms242115963
Osikov MV, Simonyan EV, Ageeva AA, Fedosov AA. Prospects of local application of melatonin for correction of immune status in thermal injury. Sovremennye problemy nauki i obrazovaniya. 2020;1:97. (In Russ.).
de Souza TR, Rocha VL, de Castro Nunes Rincon G, de Oliveira Junior ER, Celes MRN, Lima EM, Amaral AC, Miguel MP, de Menezes LB. Topical application of melatonin accelerates the maturation of skin wounds and increases collagen deposition in a rat model of diabetes. J Tissue Viability. 2022;31(4):606-613. https://doi.org/10.1016/j.jtv.2022.07.015
Bryuxina EV, Mamontova AG, Usoltseva EN. The use of melatonin in the treatment of menopausal metabolic syndrome. Klinicheskaya meditsina. 2018;96(3):208-212. (In Russ.). https://doi.org/10.18821/0023-2149-2018-96-3-208-212
Li Y, Liu H, Sun J, Tian Y, Li C. Effect of melatonin on the peripheral T lymphocyte cell cycle and levels of reactive oxygen species in patients with premature ovarian failure. Experimental and Therapeutic Medicine. 2016; 12(6):3589-3594. https://doi.org/10.3892/etm.2016.3833
Yureneva SV, Ivanets TYu, Ermakova EI, Averkova VG. Results of an open comparative randomized controlled clinical trial of the use of combination therapy, including the drug Pineamine, in postmenopausal women. Rossijskij vestnik akushera-ginekologa. 2020;20(2):86-94. (In Russ.). https://doi.org/10.17116/rosakush20202002186
Yarmolinskaya MI, Tatarova NA, Kasyan VN, Petrosyan AS. The effectiveness of non-hormonal therapy in the treatment of women with menopausal syndrome. Rossijskij vestnik akushera-ginekologa. 2021;21(2):91-101. (In Russ.). https://doi.org/10.17116/rosakush20212102191
Yureneva SV, Averkova VG. Menopausal vasomotor symptoms: central triggers, effectors, and new possibilities of pathogenetic therapy. Rossijskij vestnik akushera-ginekologa. 2018;18(5):43-48. (In Russ.). https://doi.org/10.17116/rosakush20181805143
Fang L, Li Y, Wang S, Yu Y, Li Y, Guo Y, Yan Y, Sun Y. Melatonin induces progesterone production in human granulosa-lutein cells through upregulation of StAR expression. Aging (Albany NY). 2019 Oct 16;11:9013-9024. https://doi.org/10.18632/aging.102367
Bódis J, Koppán M, Kornya L, Tinneberg HR, Török A. Influence of melatonin on basal and gonadotropin-stimulated progesterone and estradiol secretion of cultured human granulosa cells and in the superfused granulosa cell system. Gynecol Obstet Invest. 2001;52(3):198-202. https://doi.org/10.1159/000052973