The aim of the study is to identify the particular characteristics of pregnancy and childbirth for women who are either active or passive smokers during pregnancy. Material and methods. In the gestation period of more than 37 weeks and during childbirth, 185 women were examined. The first group consisted of 67 pregnant women who smoked over the whole course of their pregnancy. The second group included 58 non-smokers who were exposed to second-hand tobacco smoke throughout their pregnancy. The control (3rd) group consisted of 60 pregnant women with no history of active or passive smoking. Surveys, general clinical examinations and standard laboratory tests and imaging were conducted. A lateral flow test was carried out for rapid qualitative detection of the main nicotine metabolite in urine. Results. It was found that pregnant women in the 1st group (active smokers) and 2nd group (passive smokers) are much more likely to have moderate anemia, acute respiratory viral infections, threatened abortion, chronic placental insufficiency, low water level, and vaginitis, than the pregnant women in the control group. Morning sickness was significantly more likely to complicate the course of pregnancy for passive smokers. Patients who were either active or passive smokers experienced significantly more complications during childbirth, including premature release of amniotic fluid with meconial staining, abnormal uterine contractile activity, vaginal ruptures. During the gestation period, vomiting, anemia, vaginitis, and threatened abortion were detected. Childbirth was complicated by premature release and of amniotic water, abnormal contractile activity of the uterus, and maternal birth traumas. Conclusion. Active and passive smoking is a significant risk factor for complications during pregnancy and childbirth.