Spectrum of anti-inflammatory cytokines in pregnant women with placental insufficiencyand fetal growth retardation

Shcherbakov V.I.

Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia

Ryabichenko T.I.

Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia

Skosyreva G.A.

Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia

Trunov A.N.

Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia

Spectrum of anti-inflammatory cytokines in pregnant women with placental insufficiencyand fetal growth retardation

Authors:

Shcherbakov V.I., Ryabichenko T.I., Skosyreva G.A., Trunov A.N.

More about the authors

Journal: Russian Bulletin of Obstetrician-Gynecologist. 2019;19(3): 11‑16

DOI: 10.17116/rosakush20191903111

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To cite this article:

Shcherbakov VI, Ryabichenko TI, Skosyreva GA, Trunov AN. Spectrum of anti-inflammatory cytokines in pregnant women with placental insufficiencyand fetal growth retardation. Russian Bulletin of Obstetrician-Gynecologist. 2019;19(3):11‑16. (In Russ.)
https://doi.org/10.17116/rosakush20191903111

Подписка 2025-2 (Russian Bulletin of Obstetrician-Gynecologist)

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The aim — of this study is to investigate the ratio of proinflammatory to anti-inflammatory cytokines in placental insufficiency, which develops in the third trimester of pregnancy and is accompanied by a delay in fetal growth. Material and methods. The main group consisted of 33 pregnant women at the age of 29.1±0.9 years who had a gestation period of 33.7±0.5 weeks and were diagnosed with chronic secondary compensated fetal placental insufficiency with fetal growth retardation. The control group included 25 nominally healthy pregnant women of the same age with similar lengths of gestation. All the pregnant women underwent a full complement of clinical and laboratory examinations, including ultrasound, cardiotocography and Doppler examinations. The concentration ratios of proinflammatory (interleukin-8, interleukin-6, interferon-γ) and anti-inflammatory (interleukin-4, interleukin-10) cytokines and autoantibodies to native DNA was determined in blood serum analysis. Results. Patients of the main group were found to have a change in the level of both anti-inflammatory and pro-inflammatory cytokines, reflecting the important role of the cytokine circuit in placental insufficiency and fetal growth retardation. The influence of the makeup of the cytokines on placenta and fetal growth is presented. Conclusion. The conducted research reveals new pathogenetic features of placental insufficiency development and fetal growth retardation. Determination of the concentration of interleukin-6 as an indicator of fetal growth retardation can be recommended for implementation in clinical practice.

Keywords:

placental insufficiency

fetal growth retardation

proinflammatory (interleukin-8

interleukin-6

interferon-γ) and anti-inflammatory (interleukin-4

interleukin-10) cytokines

diagnostic value of interleukin-6 determination

Authors:

Shcherbakov V.I.

Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia

Ryabichenko T.I.

Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia

Skosyreva G.A.

Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia

Trunov A.N.

Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia

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