Biological role and therapeutic potential of phytoflavonoids and vitamin D in the treatment of patients with uterine myoma, as well as other promising pharmacological directions

Buianova S.N.; Shchukina N.A.; Babunashvili E.L.

doi:https://doi.org/10.17116/rosakush20181805136

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Abstract:

The review of the results of researches made in recent years presents new approaches to treating patients with uterine myoma. Numerous studies confirm that there is a clear pathophysiological basis for the use of phytoflavonoids to treat uterine myoma, which is extremely promising. Scientists have shown a clear relationship between the lower plasma level of vitamin D and the higher risk for uterine leiomyoma, as well as its protective role in the development of this disease. In view of the enormous importance of fibrogenesis in the pathophysiology of uterine leiomyoma, there is a continuing search for an effective antifibrotic medication for additional pathogenetic therapy. Pharmacological studies aimed to design thermosensitive nanomaterials (nanoparticles) as a depot for various drugs are promising. The accurate, controlled administration of the drug into the lesion area, including in uterine myoma, will provide its long-term delay and prevent premature inactivation, which will reduce the frequency of drug administration. The new approaches to pharmacotherapy for patients with uterine myoma can substantially enhance the efficiency of treatment and minimize the number of adverse effects.

Keywords:

uterine myoma

phytoflavonoids

curcumin

calcitriol

apoptosis

fibrogenesis

collagen

nanoparticles

Authors:

Buianova S.N.

Moskovskiĭ oblastnoĭ NII akusherstva i ginekologii

Shchukina N.A.

Moskovskiĭ oblastnoĭ NII akusherstva i ginekologii

Babunashvili E.L.

Moscow Regional Research Institute of Obstetrics and Gynecology, Ministry of Health of the Moscow Region, Moscow, Russia

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