Subclinical inflammation as a factor for the development of insulin resistance during pregnancy

Kapustin R.V.; Arzhanova O.N.

doi:https://doi.org/10.17116/rosakush201717127-36

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Abstract:

The authors carried out a systems analysis of the results of published papers on the pathophysiological pathways that develop carbohydrate metabolic disturbances in obesity and pregnancy, in the context of evaluation of low-intensity inflammatory reactions. The overexpression of proinflammatory cytokines and proteins (tumor necrosis factor-α, interleukin-6, C-reactive protein, monocyte chemoattractant protein-1) leads to subclinical inflammation, which causes insulin receptor dysfunction. This mechanism is responsible for insulin resistance processes and results in the development of gestational diabetes mellitus (GDM). It is shown that the investigation of the main proinflammatory biomarkers may serve as a basis for identifying the risk and diagnosing carbohydrate metabolic disturbances in the period of gestation and may determine an algorithm for the rational management of pregnant women with GDM. The authors declare no conflicts of interest.

Keywords:

proinflammatory cytokines

subclinical inflammation

insulin resistance

gestational diabetes mellitus

Authors:

Kapustin R.V.

NII akusherstva i ginekologii im. D.O. Otta SZO RAMN, Sankt-Peterburg

Arzhanova O.N.

NII akusherstva i ginekologii im. D.O. Otta SZO RAMN, Sankt-Peterburg

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References:

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