The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Kapustin R.V.

NII akusherstva i ginekologii im. D.O. Otta SZO RAMN, Sankt-Peterburg

Arzhanova O.N.

NII akusherstva i ginekologii im. D.O. Otta SZO RAMN, Sankt-Peterburg

Subclinical inflammation as a factor for the development of insulin resistance during pregnancy

Authors:

Kapustin R.V., Arzhanova O.N.

More about the authors

Journal: Russian Bulletin of Obstetrician-Gynecologist. 2017;17(1): 27‑36

DOI: 10.17116/rosakush201717127-36

Views: 2148

Downloaded: 31

Download PDF (RU)
Contact the author
Table of contents

SUBCLINICAL INFLAMMATION AS A FACTOR FOR THE DEVELOPMENT OF INSULIN RESISTANCE DURING PREGNANCY
SUBCLINICAL INFLAMMATION AS A FACTOR FOR THE DEVELOPMENT OF INSULIN RESISTANCE DURING PREGNANCY

To cite this article:

Kapustin RV, Arzhanova ON. Subclinical inflammation as a factor for the development of insulin resistance during pregnancy. Russian Bulletin of Obstetrician-Gynecologist. 2017;17(1):27‑36. (In Russ.)
https://doi.org/10.17116/rosakush201717127-36

 
Подписка 2025-2 (Russian Bulletin of Obstetrician-Gynecologist)
 
МСФ на ЯМ
Close metadata
Recommended articles:
Deli­very of women with gestational diabetes and uterine scar after cesa­rean section. Russian Bulletin of Obstetrician-Gynecologist. 2024;(4):63-69
Modern aspe­cts of gestational diabetes mellitus: defi­nition, risk factors. Russian Bulletin of Obstetrician-Gynecologist. 2025;(2):35-41
The role of FABP4 in the deve­lopment of fetal growth reta­rdation in women with gestational diabetes mellitus and threatened late miscarriage diagnosed in the second trimester of pregnancy. Russian Journal of Human Reproduction. 2024;(3):50-56
Impact of meta­bolic para­meters and risk factors on surfactant proteins SP-A and SP-D in abdo­minal obesity. Russian Journal of Preventive Medi­cine. 2024;(7):60-66
Insu­lin resi­stance as a cardiovascular risk factor in patients with ulce­rative coli­tis. Russian Journal of Evidence-Based Gastroenterology. 2024;(3):42-49
The effect of ethy­lmethylhydroxypyridine succinate on the para­meters of chro­nic neuroinflammation and plastic processes in the brain of old rats during course of dexa­methasone admi­nistration. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(9):115-121
Cyto­kine profile in middle-aged men with acute and chro­nic coro­nary syndrome and its rela­tion with coro­nary bed lesion seve­rity. Russian Journal of Preventive Medi­cine. 2024;(10):101-107
Surgical treatment of macromastia in benign breast dysplasia and como­rbidities. Plastic Surgery and Aesthetic Medi­cine. 2024;(4-2):5-13
Effe­ctiveness of using preventive and personalized technologies for obesity correction. Problems of Balneology, Physiotherapy and Exercise Therapy. 2024;(6-2):80-90
Features of the course of indu­ced pregnancy during the transfer of a thawed embryo in women with poly­cystic ovary syndrome. Russian Journal of Human Reproduction. 2025;(1):54-62

The authors carried out a systems analysis of the results of published papers on the pathophysiological pathways that develop carbohydrate metabolic disturbances in obesity and pregnancy, in the context of evaluation of low-intensity inflammatory reactions. The overexpression of proinflammatory cytokines and proteins (tumor necrosis factor-α, interleukin-6, C-reactive protein, monocyte chemoattractant protein-1) leads to subclinical inflammation, which causes insulin receptor dysfunction. This mechanism is responsible for insulin resistance processes and results in the development of gestational diabetes mellitus (GDM). It is shown that the investigation of the main proinflammatory biomarkers may serve as a basis for identifying the risk and diagnosing carbohydrate metabolic disturbances in the period of gestation and may determine an algorithm for the rational management of pregnant women with GDM. The authors declare no conflicts of interest.

Keywords:

proinflammatory cytokines
subclinical inflammation
insulin resistance
gestational diabetes mellitus

Authors:

Kapustin R.V.

NII akusherstva i ginekologii im. D.O. Otta SZO RAMN, Sankt-Peterburg

Arzhanova O.N.

NII akusherstva i ginekologii im. D.O. Otta SZO RAMN, Sankt-Peterburg

List of references:

  1. Challis JR, Lockwood CJ, Myatt L, Norman JE, Strauss JF, Petraglia F. Inflammation and pregnancy. Reprod Sci. 2009;16:206-215. doi:10.1177/1933719108329095
  2. Abell SK, De Courten B, Boyle JA, Teede HJ. Inflammatory and other biomarkers: role in pathophysiology and prediction of gestational diabetes mellitus. Int J Mol Sci. 2015;16:6:13442-13473. doi:10.3390/ijms160613442
  3. Ianniello F, Quagliozzi L, Caruso A, Paradisi G. Low adiponectin in overweight/obese women: Association with diabetes during pregnancy. Eur Rev Med Pharmacol Sci. 2013;17:3197-3205. doi:PMID: 24338462
  4. Gomes CP, Torloni MR, Gueuvoghlanian-Silva BY, Alexandre SM, Mattar R, Daher S. Cytokine levels in gestational diabetes mellitus: A systematic review of the literature. Am J Reprod Immunol. 2013;69:545-557. doi:10.1111/aji.12088
  5. Teede HJ, Harrison CL, Teh WT, Paul E, Allan CA. Gestational diabetes: Development of an early risk prediction tool to facilitate opportunities for prevention. Aust N Zeal J Obstet Gynaecol. 2011;51:499-504. doi:10.1111/j.1479-828X.2011.01356.x
  6. Sacks DA. Hadden DR, Maresh M, Deerochanawong C, Dyer AR, Metzger BE, Lowe LP, Coustan DR, Hod M, Oats JJ. Frequency of gestational diabetes mellitus at collaborating centers based on IADPSG consensus panel-recommended criteria: The hyperglycemia and adverse pregnancy outcome (HAPO) study. Diabetes Care. 2012;35:526-528. doi:10.2337/dc11-1641
  7. HAPO Study Cooperative Research Group. The hyperglycemia and adverse pregnancy outcome (HAPO) study. Int J Gynaecol Obstet. 2002;78:69-77.
  8. Shah BR, Retnakaran R, Booth GL. Increased risk of cardiovascular disease in young women following gestational diabetes mellitus. Diabetes Care. 2008;31:1668-1669. doi:10.2337/dc08-0706
  9. Xu J, Zhao YH, Chen YP, Yuan XL, Wang J, Zhu H, Lu CM. Maternal circulating concentrations of tumor necrosis factor-alpha, leptin, and adiponectin in gestational diabetes mellitus: a systematic review and metaanalysis. Scientific World J. 2014;2014:926932. doi:10.1155/2014/926932
  10. Catalano PM, Huston L, Amini SB, Kalhan SC. Longitudinal changes in glucose metabolism during pregnancy in obese women with normal glucose tolerance and gestational diabetes mellitus. Am J Obstet Gynecol. 1999;180:4:903-916.
  11. Brelje TC, Scharp DW, Lacy PE, Ogren L, Talamantes F, Robertson M, Friesen HG, Sorenson RL. Effect of homologous placental lactogens, prolactins, and growth hormones on islet B-cell division and insulin secretion in rat, mouse, and human islets: implication for placental lactogen regulation of islet function during pregnancy. Endocrinology. 1993;132:2:879-887.
  12. Barbour LA, Shao J, Qiao L, Leitner W, Anderson M, Friedman JE, Draznin B. Human placental growth hormone increases expression of the p85 regulatory unit of phosphatidylinositol 3-kinase and triggers severe insulin resistance in skeletal muscle. Endocrinology. 2004;145:3:1144-1450. doi:10.1210/en.2003-1297
  13. Montagnani M, Golovchenko I, Kim I, Koh GY, Goalstone ML, Mundhekar AN, Johansen M, Kucik DF, Quon MJ, Draznin B. Inhibition of phosphatidylinositol 3-kinase enhances mitogenic actions of insulin in endothelial cells. J Biol Chem. 2002;277:3:1794-1799. doi:10.1074/jbc.M103728200
  14. Catalano PM, Nizielski SE, Shao J, Preston L, Qiao L, Friedman JE. Downregulated IRS-1 and PPARgamma in obese women with gestational diabetes: relationship to FFA during pregnancy. Am J Physiol Endocrinol Metab. 2002;282:3:E522-E533. doi:10.1152/ajpendo.00124.2001
  15. Georgiou HM, Lappas M, Georgiou GM, Marita A, Bryant VJ, Hiscock R, Permezel M, Khalil Z, Rice GE. Screening for biomarkers predictive of gestational diabetes mellitus. Acta Diabetol. 2008;45:3:157-165. doi:10.1007/s00592-008-0037-8
  16. Kirwan JP, Hauguel-De Mouzon S, Lepercq J, Challier JC, Huston-Presley L, Friedman JE, Kalhan SC, Catalano PM. TNF-alpha is a predictor of insulin resistance in human pregnancy. Diabetes. 2002;51:7:2207-2213.
  17. Pradhan AD, Manson JE, Rifai N, Buring JE, Ridker PM. C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA. 2001;286:3:327-334.
  18. Lowe LP, Metzger BE, Lowe WL Jr, Dyer AR, McDade TW, McIntyre HD; HAPO Study Cooperative Research Group. Inflammatory mediators and glucose in pregnancy: results from a subset of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study. J Clin Endocrinol Metab. 2010;95:12:5427-5434. doi:10.1210/jc.2010-1662
  19. Smirnakis KV, Plati A, Wolf M, Thadhani R, Ecker JL. Predicting gestational diabetes: choosing the optimal early serum marker. Am J Obstet Gynecol. 2007;196:4:410.e1-e6; discussion 410.e6-e7. doi:10.1016/j.ajog.2006.12.011
  20. Maged AM, Moety GA, Mostafa WA, Hamed DA. Comparative study between different biomarkers for early prediction of gestational diabetes mellitus. J Matern Fetal Neonatal Med. 2014;27:11:1108-1112. doi:10.3109/14767058.2013.850489
  21. Retnakaran R, Hanley AJ, Raif N, Connelly PW, Sermer M, Zinman B. C-reactive protein and gestational diabetes: the central role of maternal obesity. J Clin Endocrinol Metab. 2003;88:8:3507-3512. doi:10.1210/jc.2003-030186
  22. Winzer C, Wagner O, Festa A, Schneider B, Roden M, Bancher-Todesca D, Pacini G, Funahashi T, Kautzky-Willer A. Plasma adiponectin, insulin sensitivity, and subclinical inflammation in women with prior gestational diabetes mellitus. Diabetes Care. 2004;27:7:1721-1727.
  23. Akinci B, Demir T, Celtik A, Baris M, Yener S, Ozcan MA, Yuksel F, Secil M, Yesil S. Serum osteoprotegerin is associated with carotid intima media thickness in women with previous gestational diabetes. Diabetes Res Clin Pract. 2008;82:2:172-178. doi:10.1016/j.diabres.2008.07.014
  24. Wolf M, Sandler L, Hsu K, Vossen-Smirnakis K, Ecker JL, Thadhani R. First-trimester C-reactive protein and subsequent gestational diabetes. Diabetes Care. 2003;26:3:819-824.
  25. Fasshauer M, Blüher M, Stumvoll M. Adipokines in gestational diabetes. Lancet Diabetes Endocrinol. 2014;2:6:488-499. doi:10.1016/S2213-8587(13)70176-1
  26. Briana DD, Malamitsi-Puchner A. Reviews: adipocytokines in normal and complicated pregnancies. Reprod Sci. 2009;16:10:921-937. doi:10.1177/1933719109336614
  27. Altinova AE, Toruner F, Bozkurt N, Bukan N, Karakoc A, Yetkin I, Ayvaz G, Cakir N, Arslan M. Circulating concentrations of adiponectin and tumor necrosis factor-alpha in gestational diabetes mellitus. Gynecol Endocrinol. 2007;23:3:161-165. doi:10.1080/09513590701227960
  28. Atègbo JM, Grissa O, Yessoufou A, Hichami A, Dramane KL, Moutairou K, Miled A, Grissa A, Jerbi M, Tabka Z, Khan NA. Modulation of adipokines and cytokines in gestational diabetes and macrosomia. J Clin Endocrinol Metab. 2006;91:10:4137-4143. doi:10.1210/jc.2006-0980
  29. Guillemette L, Lacroix M, Battista MC, Doyon M, Moreau J, Ménard J, Ardilouze JL, Perron P, Hivert MF. TNFα dynamics during the oral glucose tolerance test vary according to the level of insulin resistance in pregnant women. J Clin Endocrinol Metab. 2014;99:5:1862-1869. doi:10.1210/jc.2013-4016
  30. Gao XL, Yang HX, Zhao Y. Variations of tumor necrosis factor-alpha, leptin and adiponectin in mid-trimester of gestational diabetes mellitus. Chin Med J (Engl). 2008;121:8:701-705.
  31. Kinalski M, Telejko B, Kuźmicki M, Kretowski A, Kinalska I. Tumor necrosis factor alpha system and plasma adiponectin concentration in women with gestational diabetes. Horm Metab Res. 2005;37:7:450-454. doi:10.1055/s-2005-870238
  32. McLachlan KA, O'Neal D, Jenkins A, Alford FP. Do adiponectin, TNFalpha, leptin and CRP relate to insulin resistance in pregnancy? Studies in women with and without gestational diabetes, during and after pregnancy. Diabetes Metab Res Rev. 2006;22:2:131-138. doi:10.1002/dmrr.591
  33. López-Tinoco C, Roca M, Fernández-Deudero A, García-Valero A, Bugatto F, Aguilar-Diosdado M, Bartha JL. Cytokine profile, metabolic syndrome and cardiovascular disease risk in women with late-onset gestational diabetes mellitus. Cytokine. 2012;58:1:14-19. doi:10.1016/j.cyto.2011.12.004
  34. Salmi AA, Zaki NM, Zakaria R, Nor Aliza AG, Rasool AH. Arterial stiffness, inflammatory and pro-atherogenic markers in gestational diabetes mellitus. Vasa. 2012;41:2:96-104. doi:10.1024/0301-1526/a000171
  35. Saucedo R, Zarate A, Basurto L, Hernandez M, Puello E, Galvan R, Campos S. Relationship between circulating adipokines and insulin resistance during pregnancy and postpartum in women with gestational diabetes. Arch Med Res. 2011;42:4:318-323. doi:10.1016/j.arcmed.2011.06.009
  36. Montazeri S, Nalliah S, Radhakrishnan AK. Association between polymorphisms in human tumor necrosis factor-alpha (-308) and -beta (252) genes and development of gestational diabetes mellitus. Diabetes Res Clin Pract. 2010;88:2:139-145. doi:10.1016/j.diabres.2010.01.028
  37. Gueuvoghlanian-Silva BY, Torloni MR, Mattar R, de Oliveira LS, Scomparini FB, Nakamura MU, Daher S. Profile of inflammatory mediators in gestational diabetes mellitus: phenotype and genotype. Am J Reprod Immunol. 2012;67:3:241-250. doi:10.1111/j.1600-0897.2011.01090.x
  38. Vozarova B, Weyer C, Hanson K, Tataranni PA, Bogardus C, Pratley RE. Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion. Obes Res. 2001;9:7:414-417. doi:10.1038/oby.2001.54
  39. Morisset AS, Dubé MC, Côté JA, Robitaille J, Weisnagel SJ, Tchernof A. Circulating interleukin-6 concentrations during and after gestational diabetes mellitus. Acta Obstet Gynecol Scand. 2011;90:5:524-530. doi:10.1111/j.1600-0412.2011.01094.x
  40. Kuzmicki M, Telejko B, Szamatowicz J, Zonenberg A, Nikolajuk A, Kretowski A, Gorska M. High resistin and interleukin-6 levels are associated with gestational diabetes mellitus. Gynecol Endocrinol. 2009;25:4:258-263. doi:10.1080/09513590802653825
  41. Hassiakos D, Eleftheriades M, Papastefanou I3, Lambrinoudaki I, Kappou D, Lavranos D, Akalestos A, Aravantinos L, Pervanidou P, Chrousos G. Increased maternal serum interleukin-6 concentrations at 11 to 14 weeks of gestation in low risk pregnancies complicated with gestational diabetes mellitus: development of a prediction model. Horm Metab Res. 2016;48:1:35-41. doi:10.1055/s-0034-1395659
  42. Abdel Gader AG, Khashoggi TY, Habib F, Awadallah SB. Haemostatic and cytokine changes in gestational diabetes mellitus. Gynecol Endocrinol. 2011;27:5:356-360. doi:10.3109/09513590.2010.495241
  43. Winkler G, Cseh K, Baranyi E, Melczer Z, Speer G, Hajós P, Salamon F, Turi Z, Kovács M, Vargha P, Karádi I. Tumor necrosis factor system in insulin resistance in gestational diabetes. Diabetes Res Clin Pract. 2002;56:2:93-99.
  44. Charo IF, Taubman MB. Chemokines in the pathogenesis of vascular disease. Circ Res. 2004;95:9:858-866. doi:10.1161/01.RES.0000146672.10582.17
  45. Wellen KE, Hotamisligil GS. Obesity-induced inflammatory changes in adipose tissue. J Clin Invest. 2003;112:1785-1788. doi:10.1172/JCI20514
  46. Kamei N, Tobe K, Suzuki R, Ohsugi M, Watanabe T, Kubota N, Ohtsuka-Kowatari N, Kumagai K, Sakamoto K, Kobayashi M, Yamauchi T, Ueki K, Oishi Y, Nishimura S, Manabe I, Hashimoto H, Ohnishi Y, Ogata H, Tokuyama K, Tsunoda M, Ide T, Murakami K, Nagai R, Kadowaki T. Over-expression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance. J Biol Chem. 2006;281:26602-26614.
  47. Mine S, Okada Y, Tanikawa T, Kawahara C, Tabata T, Tanaka Y. Increased expression levels of monocyte CCR2 and monocyte chemoattractant protein-1 in patients with diabetes mellitus. Biochem Biophys Res Commun. 2006;344:3:780-785. doi:10.1016/j.bbrc.2006.03.197
  48. Martinovic I, Abegunewardene N, Seul M, Vosseler M, Hor- stick G, Buerke M, Darius H, Lundemann S. Elevated monocyte chemoattractant protein-1 serum levels in patients at risk for coronary artery disease. Circ J. 2005;69:1484-1489.
  49. Ihm CG, Park JK, Hong SP, Lee TW, Cho BS, Kim MJ, Cha DR, Ha H. A high glucose concentration stimulates the expression of monocyte chemotactic peptide 1 in human mesangial cells. Nephron. 1998;79:33-37.
  50. Panee J. Monocyte Chemoattractant Protein 1 (MCP-1) in obesity and diabetes. Cytokine. 2012;60:1:1-12. doi:10.1016/j.cyto.2012.06.018
  51. Denison FC, Kelly RW, Calder AA. Differential secretion of chemokines from peripheral blood in pregnant compared with non-pregnant women. J Reprod Immunol. 1997;34:3:225-240.
  52. Klein K, Satler M, Elhenicky M, Brix J, Krzyzanowska K, Schernthaner G, Husslein PW, Schernthaner GH. Circulating levels of MCP-1 are increased in women with gestational diabetes. Prenat Diagn. 2008;28:9:845-851. doi:10.1002/pd.2064
  53. Di Benedetto A, Russo GT, Corrado F, Di Cesare E, Alessi E, Nicocia G, D'Anna R, Cucinotta D. Inflammatory markers in women with a recent history of gestational diabetes mellitus. J Endocrinol Invest. 2005;28:1:34-38.
  54. Telejko B, Kuzmicki M, Zonenberg A, Niedziolko-Bagniuk K, Nikolajuk A, Szamatowicz J, Gorska M. Circulating monocyte chemoattractant protein-1 in women with gestational diabetes. Folia Histochem Cytobiol. 2007;45:Suppl 1:S153-S156.
  55. Denison FC, Roberts KA, Barr SM, Norman JE. Obesity, pregnancy, inflammation, and vascular function. Reproduction. 2010;140:3:373-385. doi:10.1530/REP-10-0074

Close metadata

Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.