The pathogenesis of preeclampsia in pregnant women: Some aspects

Levchenko V.G.; Zorina V.N.; Bazhenova L.G.; Zorina R.M.; Zorin N.A.

doi:https://doi.org/

Levchenko V.G.

Kafedra akusherstva i ginekologii

Zorina V.N.

NIL immunokhimii Novokuznetskogo gosudarstvennogo instituta usovershenstvovaniia vracheĭ

Bazhenova L.G.

Kafedra akusherstva i ginekologii

Zorina R.M.

NIL immunokhimii Novokuznetskogo gosudarstvennogo instituta usovershenstvovaniia vracheĭ

Zorin N.A.

NIL immunokhimii Novokuznetskogo gosudarstvennogo instituta usovershenstvovaniia vracheĭ

The pathogenesis of preeclampsia in pregnant women: Some aspects

Authors:

Levchenko V.G., Zorina V.N., Bazhenova L.G., Zorina R.M., Zorin N.A.

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Journal: Russian Bulletin of Obstetrician-Gynecologist. 2010;10(3): 21‑25

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To cite this article:

Levchenko VG, Zorina VN, Bazhenova LG, Zorina RM, Zorin NA. The pathogenesis of preeclampsia in pregnant women: Some aspects. Russian Bulletin of Obstetrician-Gynecologist. 2010;10(3):21‑25. (In Russ.)

Подписка 2026 Российский вестник акушера-гинеколога (Russian Bulletin of Obstetrician-Gynecologist)

Использование инфографики авторами научных работ

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Abstract:

Preeclampsia (PE) or gestosis is a most common complication of pregnancy; however, there is no consensus of opinion as to what is a trigger mechanism in the development of this pathology. The review considers some new aspects of four most likely causes of PE: 1) the genetic determination of the disease, which includes defects in the synthesis of a number of proteins; 2) congenital or functional impairments in the maternal immune system, which result in an imbalance in immune cells and their synthesized cytokines and in activated synthesis of various autoantibodies; 3) the systemic inflammatory response syndrome and endogenous intoxication syndrome particularly when infection is present in the maternal reproductive system prior to pregnancy; 4) superoxide stress of organs, tissues and above all individual regulatory proteins, including the macroglobulin family proteins that perform a great deal of regulatory-transport functions in the body and are a component of innate immunity.

Keywords:

preeclampsia

gestosis

systemic inflammatory response syndrome

superoxide stress

macroglobulin

innate immunity

Authors:

Levchenko V.G.

Kafedra akusherstva i ginekologii

Zorina V.N.

NIL immunokhimii Novokuznetskogo gosudarstvennogo instituta usovershenstvovaniia vracheĭ

Bazhenova L.G.

Kafedra akusherstva i ginekologii

Zorina R.M.

NIL immunokhimii Novokuznetskogo gosudarstvennogo instituta usovershenstvovaniia vracheĭ

Zorin N.A.

NIL immunokhimii Novokuznetskogo gosudarstvennogo instituta usovershenstvovaniia vracheĭ

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