Modern methods of diseases and microbiological processes express-diagnostic are principally based on classical microbiological analyzes. These analyzes require many stages what causes their prolongation, practically excepts an express diagnosis and does not meet the epidemiological and clinical practice «at the place of treatment». Therefore development, inclusion and application of the laser fluorescence diagnostic express-methods in clinical practice gives an opportunity for quick germs indication, determination of their species specificity and sensitivity to antimicrobial medications. It will improve quality and efficiency of the dental treatment in clinical practice.