The patients having defects in the dental arches and concomitant age-related hypogonadism not infrequently present with osteopenic syndrome and disturbances in the microarchitectonic patterns of the jaw bones revealed by means of cone-beam computed tomography (CBCT). The objective of the present study was to improve the effectiveness of dental implantation in the patients with osteopenic syndrome. Material and methods. The study included 25 women and 25 men having defects in the dental arches and concomitant age-related hypogonadism examined at the stage of planning dental implantation for the elucidation of the state of bone re-modeling. The densitometric study involved the central and peripheral portions of the skeletal system; it was supplemented by the analyses of the blood for the detection and identification of the markers of bone metabolism and the characteristic of the jaw bone architectonics by means of CBCT. Results. The patients presenting with osteopenic syndrome had defects in the architectonics of the jaw bones. The combined anti-osteoporotic treatment using bis-phosphonate preparations resulted in the normalization of the quality of the bone tissue. Corrective therapy with ibandronate caused a rise in the blood level of parathyroid hormone. The postoperative complications were prevented by the adequate choice of the doses of calcium carbonate and vitamin D3 with a view to reducing the blood paratirin level. Conclusion. The maintenance of the plasma level of parathyroid hormone within the normal range is an important indicator for the success of osteoplastic surgery and dental implantation; hence, the necessity of the dynamic control of its concentration in the patients having defects in the dental arches and concomitant age-related hypogonadism who develop osteopenic syndrome.